Cytotoxic activity of oleocanthal isolated from virgin olive oil on human melanoma cells S Fogli, C Arena, S Carpi, B Polini, S Bertini, M Digiacomo, F Gado, ... Nutrition and cancer 68 (5), 873-877, 2016 | 97 | 2016 |
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer B Polini, M Digiacomo, S Carpi, S Bertini, F Gado, G Saccomanni, ... Toxicology in Vitro 52, 243-250, 2018 | 80 | 2018 |
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief F Gado, L Di Cesare Mannelli, E Lucarini, S Bertini, E Cappelli, ... Journal of medicinal chemistry 62 (1), 276-287, 2018 | 79 | 2018 |
Synthesis and Photophysical Properties of 3-Amino-4-arylpyridin-2 (1Н)-ones AL Shatsauskas, AA Abramov, SA Chernenko, AS Kostyuchenko, ... Synthesis 52 (02), 227-238, 2020 | 40 | 2020 |
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery F Gado, S Meini, S Bertini, M Digiacomo, M Macchia, C Manera Future medicinal chemistry 11 (15), 2019-2037, 2019 | 40 | 2019 |
Design, synthesis, and biological activity of new CB2 receptor ligands: From orthosteric and allosteric modulators to dualsteric/bitopic ligands F Gado, R Ferrisi, B Polini, KA Mohamed, C Ricardi, E Lucarini, S Carpi, ... Journal of Medicinal Chemistry 65 (14), 9918-9938, 2022 | 24 | 2022 |
Polypharmacological profile of 1, 2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system A Chicca, C Arena, S Bertini, F Gado, E Ciaglia, M Abate, M Digiacomo, ... European journal of medicinal chemistry 154, 155-171, 2018 | 23 | 2018 |
Positive allosteric modulation of CB1 and CB2 cannabinoid receptors enhances the neuroprotective activity of a dual CB1R/CB2R orthosteric agonist B Polini, C Cervetto, S Carpi, S Pelassa, F Gado, R Ferrisi, S Bertini, ... Life 10 (12), 333, 2020 | 22 | 2020 |
Traditional uses of cannabinoids and new perspectives in the treatment of multiple sclerosis F Gado, M Digiacomo, M Macchia, S Bertini, C Manera Medicines 5 (3), 91, 2018 | 22 | 2018 |
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor S Bertini, A Chicca, F Gado, C Arena, D Nieri, M Digiacomo, ... Bioorganic & medicinal chemistry 25 (24), 6427-6434, 2017 | 22 | 2017 |
Polyphenols from thinned young apples: HPLC-HRMS profile and evaluation of their anti-oxidant and anti-inflammatory activities by proteomic studies G Ferrario, G Baron, F Gado, L Della Vedova, E Bombardelli, M Carini, ... Antioxidants 11 (8), 1577, 2022 | 21 | 2022 |
Liquid chromatography–high-resolution mass spectrometry (LC-HRMS) profiling of commercial enocianina and evaluation of their antioxidant and anti-inflammatory activity L Della Vedova, G Ferrario, F Gado, A Altomare, M Carini, P Morazzoni, ... Antioxidants 11 (6), 1187, 2022 | 21 | 2022 |
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice L Shapiro, F Gado, C Manera, A Escayg Neuropharmacology 188, 108448, 2021 | 21 | 2021 |
Anti-inflammatory activity of a CB2 selective cannabinoid receptor agonist: Signaling and cytokines release in blood mononuclear cells A Capozzi, D Caissutti, V Mattei, F Gado, S Martellucci, A Longo, ... Molecules 27 (1), 64, 2021 | 19 | 2021 |
Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases R Ferrisi, C Ceni, S Bertini, M Macchia, C Manera, F Gado Pharmacological Research 170, 105607, 2021 | 19 | 2021 |
Targeting Nrf2 and NF-κB signaling pathways in cancer prevention: The role of apple phytochemicals F Gado, G Ferrario, L Della Vedova, B Zoanni, A Altomare, M Carini, ... Molecules 28 (3), 1356, 2023 | 16 | 2023 |
The endocannabinoid system dual-target ligand N-cycloheptyl-1, 2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse … C Arena, F Gado, LDC Mannelli, C Cervetto, S Carpi, I Reynoso-Moreno, ... European journal of medicinal chemistry 208, 112858, 2020 | 15 | 2020 |
Bergamot leaf extract treats cardiorenal metabolic syndrome and associated pathophysiological factors in rats fed with a high sugar fat diet JS Siqueira, TA Vieira, ET Nakandakare-Maia, TLN Palacio, F Sarzi, ... Molecular and Cellular Endocrinology 556, 111721, 2022 | 13 | 2022 |
Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R) R Ferrisi, F Gado, B Polini, C Ricardi, KA Mohamed, LA Stevenson, ... Frontiers in Chemistry 10, 984069, 2022 | 13 | 2022 |
Modification on the 1, 2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system F Gado, C Arena, C La Fauci, I Reynoso-Moreno, S Bertini, M Digiacomo, ... Bioorganic chemistry 94, 103353, 2020 | 13 | 2020 |