| Binding of released Bim to Mcl-1 is a mechanism of intrinsic resistance to ABT-199 which can be overcome by combination with daunorubicin or cytarabine in AML cells X Niu, J Zhao, J Ma, C Xie, H Edwards, G Wang, JT Caldwell, S Xiang, ... Clinical Cancer Research 22 (17), 4440-4451, 2016 | 226 | 2016 |
| HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα M Zhang, S Xiang, HY Joo, L Wang, KA Williams, W Liu, C Hu, D Tong, ... Molecular cell 55 (1), 31-46, 2014 | 154 | 2014 |
| Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration KA Williams, M Zhang, S Xiang, C Hu, JY Wu, S Zhang, M Ryan, AD Cox, ... Journal of Biological Chemistry 288 (46), 33156-33170, 2013 | 124 | 2013 |
| GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors A Kazi, S Xiang, H Yang, D Delitto, J Trevino, RHY Jiang, M Ayaz, ... Nature communications 9 (1), 5154, 2018 | 117 | 2018 |
| Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas D Luo, B Zhang, L Lv, S Xiang, Y Liu, J Ji, D Deng Laboratory Investigation 86 (6), 591-598, 2006 | 101 | 2006 |
| Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells L Wang, S Xiang, KA Williams, H Dong, W Bai, SV Nicosia, S Khochbin, ... PloS one 7 (9), e44265, 2012 | 94 | 2012 |
| Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation Y Yang, AKW Tse, P Li, Q Ma, S Xiang, SV Nicosia, E Seto, X Zhang, ... Oncogene 30 (19), 2207-2218, 2011 | 76 | 2011 |
| Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors A Kazi, S Xiang, H Yang, L Chen, P Kennedy, M Ayaz, S Fletcher, ... Clinical Cancer Research 25 (19), 5984-5996, 2019 | 71 | 2019 |
| Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2 R Radhakrishnan, Y Li, S Xiang, F Yuan, Z Yuan, E Telles, J Fang, ... Journal of Biological Chemistry 290 (37), 22795-22804, 2015 | 63 | 2015 |
| Ubiquitin-specific peptidase 10 (USP10) deubiquitinates and stabilizes MutS homolog 2 (MSH2) to regulate cellular sensitivity to DNA damage M Zhang, C Hu, D Tong, S Xiang, K Williams, W Bai, GM Li, G Bepler, ... Journal of Biological Chemistry 291 (20), 10783-10791, 2016 | 53 | 2016 |
| The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53 C Hu, M Zhang, N Moses, C Hu, L Polin, W Chen, H Jang, J Heyza, ... Cell death & disease 11 (5), 328, 2020 | 48 | 2020 |
| Methylation status of individual CpG sites within Alu elements in the human genome and Alu hypomethylation in gastric carcinomas S Xiang, Z Liu, B Zhang, J Zhou, BD Zhu, J Ji, D Deng BMC cancer 10, 1-11, 2010 | 45 | 2010 |
| Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity JY Wu, S Xiang, M Zhang, B Fang, H Huang, OK Kwon, Y Zhao, Z Yang, ... Journal of Biological Chemistry 293 (6), 1976-1993, 2018 | 41 | 2018 |
| HDAC6 regulates DNA damage response via deacetylating MLH1 M Zhang, C Hu, N Moses, J Haakenson, S Xiang, D Quan, B Fang, ... Journal of Biological Chemistry 294 (15), 5813-5826, 2019 | 37 | 2019 |
| The p16-Specific Reactivation and Inhibition of Cell Migration Through Demethylation of CpG Islands by Engineered Transcription Factors B Zhang, S Xiang, Q Zhong, Y Yin, L Gu, D Deng Human Gene Therapy 23 (10), 1071-1081, 2012 | 30 | 2012 |
| Global phosphoproteomics reveal CDK suppression as a vulnerability to KRas addiction in pancreatic cancer A Kazi, L Chen, S Xiang, R Vangipurapu, H Yang, F Beato, B Fang, ... Clinical Cancer Research 27 (14), 4012-4024, 2021 | 29 | 2021 |
| The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells H Yang, S Xiang, A Kazi, SM Sebti Journal of Biological Chemistry 295 (10), 3055-3063, 2020 | 26 | 2020 |
| HDAC6-Dependent functions in tumor cells: Crossroad with the MAPK Pathways J Haakenson, JY Wu, S Xiang, KA Williams, W Bai, X Zhang Critical Reviews™ in Oncogenesis 20 (1-2), 2015 | 19 | 2015 |
| The CMG helicase and cancer: a tumor “engine” and weakness with missing mutations S Xiang, DR Reed, MG Alexandrow Oncogene 42 (7), 473-490, 2023 | 18 | 2023 |
| HDAC6 regulates radiosensitivity of non-small cell lung cancer by promoting degradation of Chk1 N Moses, M Zhang, JY Wu, C Hu, S Xiang, X Geng, Y Chen, W Bai, ... Cells 9 (10), 2237, 2020 | 18 | 2020 |