| MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1 K Yamamoto, H Okano, W Miyagawa, R Visse, Y Shitomi, S Santamaria, ... Matrix Biology 56, 57-73, 2016 | 190 | 2016 |
| N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential … E Nuti, F Casalini, SI Avramova, S Santamaria, G Cercignani, L Marinelli, ... Journal of medicinal chemistry 52 (15), 4757-4773, 2009 | 82 | 2009 |
| ADAMTS proteases in cardiovascular physiology and disease S Santamaria, R de Groot Open biology 10 (12), 200333, 2020 | 74 | 2020 |
| Inhibition of shedding of low‐density lipoprotein receptor–related protein 1 reverses cartilage matrix degradation in osteoarthritis K Yamamoto, S Santamaria, KA Botkjaer, J Dudhia, L Troeberg, Y Itoh, ... Arthritis & Rheumatology 69 (6), 1246-1256, 2017 | 72 | 2017 |
| Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors E Nuti, L Panelli, F Casalini, SI Avramova, E Orlandini, S Santamaria, ... Journal of medicinal chemistry 52 (20), 6347-6361, 2009 | 71 | 2009 |
| ADAMTS‐5: A difficult teenager turning 20 S Santamaria International journal of experimental pathology 101 (1-2), 4-20, 2020 | 59 | 2020 |
| Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation S Santamaria, N Reglińska-Matveyev, M Gierula, RM Camire, ... Journal of Biological Chemistry 292 (22), 9335-9344, 2017 | 53 | 2017 |
| Proteomic discovery of substrates of the cardiovascular protease ADAMTS7 A Colige, C Monseur, JTB Crawley, S Santamaria, R de Groot Journal of Biological Chemistry 294 (20), 8037-8045, 2019 | 48 | 2019 |
| Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2) S Santamaria, K Yamamoto, K Botkjaer, C Tape, MR Dyson, J McCafferty, ... Biochemical Journal 471 (3), 391-401, 2015 | 48 | 2015 |
| Sugar‐Based Arylsulfonamide Carboxylates as Selective and Water‐Soluble Matrix Metalloproteinase‐12 Inhibitors E Nuti, D Cuffaro, F D'Andrea, L Rosalia, L Tepshi, M Fabbi, G Carbotti, ... ChemMedChem 11 (15), 1626-1637, 2016 | 47 | 2016 |
| Potent arylsulfonamide inhibitors of tumor necrosis factor-α converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models E Nuti, F Casalini, SI Avramova, S Santamaria, M Fabbi, S Ferrini, ... Journal of medicinal chemistry 53 (6), 2622-2635, 2010 | 47 | 2010 |
| Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene) sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors E Nuti, F Casalini, S Santamaria, P Gabelloni, S Bendinelli, E Da Pozzo, ... European journal of medicinal chemistry 46 (7), 2617-2629, 2011 | 46 | 2011 |
| Exosites in hypervariable loops of ADAMTS spacer domains control substrate recognition and proteolysis S Santamaria, K Yamamoto, A Teraz-Orosz, C Koch, SS Apte, R de Groot, ... Scientific reports 9 (1), 10914, 2019 | 43 | 2019 |
| Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo KA Botkjaer, HF Kwok, MG Terp, A Karatt-Vellatt, S Santamaria, ... Oncotarget 7 (13), 16773, 2016 | 43 | 2016 |
| Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation E Nuti, S Santamaria, F Casalini, K Yamamoto, L Marinelli, V La Pietra, ... European journal of medicinal chemistry 62, 379-394, 2013 | 43 | 2013 |
| Monoclonal antibodies against metzincin targets S Santamaria, R de Groot British journal of pharmacology 176 (1), 52-66, 2019 | 42 | 2019 |
| Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach DR Martin, S Santamaria, CD Koch, J Ahnström, SS Apte Journal of proteomics 249, 104358, 2021 | 34 | 2021 |
| Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase JLH Madsen, TL Andersen, S Santamaria, H Nagase, JJ Enghild, ... Journal of medicinal chemistry 55 (17), 7900-7908, 2012 | 32 | 2012 |
| Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization V La Pietra, L Marinelli, S Cosconati, FS Di Leva, E Nuti, S Santamaria, ... European journal of medicinal chemistry 47, 143-152, 2012 | 31 | 2012 |
| Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models E Nuti, F Casalini, S Santamaria, M Fabbi, G Carbotti, S Ferrini, L Marinelli, ... Journal of medicinal chemistry 56 (20), 8089-8103, 2013 | 29 | 2013 |