The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake Á de Mingo Pulido, K Hänggi, DP Celias, A Gardner, J Li, ... Immunity 54 (6), 1154-1167. e7, 2021 | 172 | 2021 |
The unfolded protein response mediator PERK governs myeloid cell-driven immunosuppression in tumors through inhibition of STING signaling E Mohamed, RA Sierra, J Trillo-Tinoco, Y Cao, P Innamarato, KK Payne, ... Immunity 52 (4), 668-682. e7, 2020 | 159 | 2020 |
Necroptosis execution is mediated by plasma membrane nanopores independent of calcium U Ros, A Peña-Blanco, K Hänggi, U Kunzendorf, S Krautwald, ... Cell reports 19 (1), 175-187, 2017 | 134 | 2017 |
Targeting p38 or MK2 enhances the anti-leukemic activity of Smac-mimetics N Lalaoui, K Hänggi, G Brumatti, D Chau, NYN Nguyen, L Vasilikos, ... Cancer cell 29 (2), 145-158, 2016 | 124 | 2016 |
Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells CM Anadon, X Yu, K Hänggi, S Biswas, RA Chaurio, A Martin, KK Payne, ... Cancer Cell 40 (5), 545-557. e13, 2022 | 112 | 2022 |
Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection M Steger, O Murina, D Hühn, LP Ferretti, R Walser, K Hänggi, L Lafranchi, ... Molecular cell 50 (3), 333-343, 2013 | 108 | 2013 |
The immune microenvironment and cancer metastasis A El-Kenawi, K Hänggi, B Ruffell Cold Spring Harbor Perspectives in Medicine 10 (4), a037424, 2020 | 97 | 2020 |
FANCD2 and CtIP cooperate to repair DNA interstrand crosslinks O Murina, C von Aesch, U Karakus, LP Ferretti, HA Bolck, K Hänggi, ... Cell reports 7 (4), 1030-1038, 2014 | 96 | 2014 |
Cell death, therapeutics, and the immune response in cancer K Hänggi, B Ruffell Trends in cancer 9 (5), 381-396, 2023 | 90 | 2023 |
RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function K Hänggi, L Vasilikos, AF Valls, R Yerbes, J Knop, LM Spilgies, K Rieck, ... Cell death & disease 8 (2), e2588-e2588, 2017 | 87 | 2017 |
Inhibitor of apoptosis protein-1 regulates tumor necrosis factor–mediated destruction of intestinal epithelial cells T Grabinger, KJ Bode, J Demgenski, C Seitz, ME Delgado, F Kostadinova, ... Gastroenterology 152 (4), 867-879, 2017 | 75 | 2017 |
TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization A Gardner, Á de Mingo Pulido, K Hänggi, S Bazargan, A Onimus, ... Journal for immunotherapy of cancer 10 (1), e003571, 2022 | 38 | 2022 |
Oncogenic KRAS drives immune suppression in colorectal cancer K Hänggi, B Ruffell Cancer Cell 35 (4), 535-537, 2019 | 24 | 2019 |
Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers S Biswas, G Mandal, CM Anadon, RA Chaurio, LU Lopez-Bailon, ... Immunity 56 (11), 2570-2583. e6, 2023 | 19 | 2023 |
Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI) JH Lockhart, HD Ackerman, K Lee, M Abdalah, AJ Davis, N Hackel, ... NPJ Precision Oncology 7 (1), 68, 2023 | 6 | 2023 |
RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor HA Bolck, S Przetocka, R Meier, C von Aesch, C Zurfluh, K Hänggi, ... Cells 11 (4), 643, 2022 | 4 | 2022 |
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity K Hänggi, J Li, A Gangadharan, X Liu, DP Celias, O Osunmakinde, ... Cancer Cell 42 (12), 2015-2031. e11, 2024 | 3 | 2024 |
Loss of cIAP1 in endothelial cells limits metastatic extravasation through tumor-derived lymphotoxin alpha L Vasilikos, K Hänggi, LM Spilgies, S Kisele, S Rufli, WWL Wong Cancers 13 (4), 599, 2021 | 3 | 2021 |
Investigating the mechanisms involved in HMGB1-dependent DNA uptake and STING activation in dendritic cells DP Celias, K Hänggi, B Ruffell Cancer Research 83 (7_Supplement), 678-678, 2023 | 1 | 2023 |
Abstract PO-082: Automated tumor segmentation, grading, and analysis of tumor heterogeneity in preclinical models of lung adenocarcinoma JH Lockhart, HD Ackerman, K Lee, M Abdalah, A Davis, N Montey, ... Clinical Cancer Research 27 (5_Supplement), PO-082-PO-082, 2021 | 1 | 2021 |