| Inflammation and immune dysfunction in Parkinson disease MG Tansey, RL Wallings, MC Houser, MK Herrick, CE Keating, V Joers Nature Reviews Immunology 22 (11), 657-673, 2022 | 828 | 2022 |
| Cellular processes associated with LRRK 2 function and dysfunction R Wallings, C Manzoni, R Bandopadhyay The FEBS journal 282 (15), 2806-2826, 2015 | 199 | 2015 |
| LRRK2 regulation of immune-pathways and inflammatory disease RL Wallings, MG Tansey Biochemical Society Transactions 47 (6), 1581-1595, 2019 | 144 | 2019 |
| Lysosomal dysfunction at the centre of Parkinson’s disease and frontotemporal dementia/amyotrophic lateral sclerosis RL Wallings, SW Humble, ME Ward, R Wade-Martins Trends in neurosciences 42 (12), 899-912, 2019 | 125 | 2019 |
| LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function R Wallings, N Connor-Robson, R Wade-Martins Human molecular genetics 28 (16), 2696-2710, 2019 | 121 | 2019 |
| LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function M Sloan, J Alegre-Abarrategui, D Potgieter, AK Kaufmann, R Exley, ... Human molecular genetics 25 (5), 951-963, 2016 | 83 | 2016 |
| LRRK2 at the interface between peripheral and central immune function in Parkinson’s RL Wallings, MK Herrick, MG Tansey Frontiers in Neuroscience 14, 443, 2020 | 68 | 2020 |
| Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism J Ng, S Barral, C De La Fuente Barrigon, G Lignani, FA Erdem, ... Science translational medicine 13 (594), eaaw1564, 2021 | 36 | 2021 |
| Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system MC Houser, O Uriarte Huarte, RL Wallings, CE Keating, KP MacPherson, ... Frontiers in Immunology 13, 1056417, 2022 | 24 | 2022 |
| APOE and immunity: Research highlights CM Kloske, CJ Barnum, AF Batista, EM Bradshaw, AM Brickman, G Bu, ... Alzheimer's & Dementia 19 (6), 2677-2696, 2023 | 15 | 2023 |
| WHOPPA enables parallel assessment of leucine-rich repeat kinase 2 and glucocerebrosidase enzymatic activity in Parkinson’s disease monocytes RL Wallings, LP Hughes, HA Staley, ZD Simon, NR McFarland, ... Frontiers in cellular neuroscience 16, 892899, 2022 | 15 | 2022 |
| Linking mitochondria to the immune response RL Wallings, MK Herrick, MG Tansey Elife 9, e56214, 2020 | 11 | 2020 |
| Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease DA Gillett, RL Wallings, O Uriarte Huarte, MG Tansey Journal of Neuroinflammation 20 (1), 286, 2023 | 7 | 2023 |
| ASO-mediated knockdown or kinase inhibition of G2019S-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages RL Wallings, JR Mark, HA Staley, DA Gillett, N Neighbarger, ... Molecular Therapy Nucleic Acids 34, 2023 | 5 | 2023 |
| Disease mechanisms as subtypes: lysosomal dysfunction in the endolysosomal Parkinson's disease subtype A Mamais, R Wallings, EM Rocha Handbook of Clinical Neurology 193, 33-51, 2023 | 4 | 2023 |
| Investigating the Role and Regulation of GPNMB in Progranulin-deficient Macrophages DA Gillett, NK Neighbarger, C Cole, RL Wallings, MG Tansey Frontiers in Immunology 15, 1417836, 2024 | 1 | 2024 |
| Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner HA Staley, JE Jernigan, MKL Bolen, AM Titus, N Neighbarger, C Cole, ... Journal of Neuroinflammation 21 (1), 280, 2024 | | 2024 |
| MHCII deletion in mouse myeloid cells alters T-cell subset frequencies and inflammatory responses to alpha-synuclein pathology and epigenetic analysis of human monocytes … EM Kline, JE Jernigan, CD Scharer, J Maurer, SL Hicks, MK Herrick, ... bioRxiv, 2024.08. 31.610581, 2024 | | 2024 |
| ASO-mediated knockdown of GPNMB in mutant-GRN and Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses RL Wallings, DA Gillett, HA Staley, S Mahn, J Mark, N Neighbarger, ... bioRxiv, 2024.07. 22.604676, 2024 | | 2024 |
| The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner RL Wallings, K McFarland, HA Staley, N Neighbarger, S Schaake, ... bioRxiv, 2023.10. 12.562063, 2023 | | 2023 |