Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques X Jin, DE Bauer, SE Tuttleton, S Lewin, A Gettie, J Blanchard, CE Irwin, ... The Journal of experimental medicine 189 (6), 991-998, 1999 | 1832 | 1999 |
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity LS Weinberger, JC Burnett, JE Toettcher, AP Arkin, DV Schaffer Cell 122 (2), 169-182, 2005 | 752 | 2005 |
Transcriptional burst frequency and burst size are equally modulated across the human genome RD Dar, BS Razooky, A Singh, TV Trimeloni, JM McCollum, CD Cox, ... Proceedings of the National Academy of Sciences 109 (43), 17454-17459, 2012 | 564 | 2012 |
Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy H Mohri, AS Perelson, K Tung, RM Ribeiro, B Ramratnam, M Markowitz, ... The Journal of experimental medicine 194 (9), 1277-1288, 2001 | 485 | 2001 |
Transcriptional bursting from the HIV-1 promoter is a significant source of stochastic noise in HIV-1 gene expression A Singh, B Razooky, CD Cox, ML Simpson, LS Weinberger Biophysical journal 98 (8), L32-L34, 2010 | 283 | 2010 |
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism D Boehm, V Calvanese, RD Dar, S Xing, S Schroeder, L Martins, K Aull, ... Cell cycle 12 (3), 452-462, 2013 | 276 | 2013 |
A hardwired HIV latency program BS Razooky, A Pai, K Aull, IM Rouzine, LS Weinberger Cell 160 (5), 990-1001, 2015 | 253 | 2015 |
Transient-mediated fate determination in a transcriptional circuit of HIV LS Weinberger, RD Dar, ML Simpson Nature genetics 40 (4), 466-470, 2008 | 248 | 2008 |
Screening for noise in gene expression identifies drug synergies RD Dar, NN Hosmane, MR Arkin, RF Siliciano, LS Weinberger Science 344 (6190), 1392-1396, 2014 | 229 | 2014 |
Stochastic gene expression as a molecular switch for viral latency A Singh, LS Weinberger Current opinion in microbiology 12 (4), 460-466, 2009 | 159 | 2009 |
Dynamics of protein noise can distinguish between alternate sources of gene‐expression variability A Singh, BS Razooky, RD Dar, LS Weinberger Molecular systems biology 8 (1), 607, 2012 | 122 | 2012 |
An evolutionary role for HIV latency in enhancing viral transmission IM Rouzine, AD Weinberger, LS Weinberger Cell 160 (5), 1002-1012, 2015 | 114 | 2015 |
Attacking latent HIV with convertibleCAR-T cells, a highly adaptable killing platform E Herzig, KC Kim, TA Packard, N Vardi, R Schwarzer, A Gramatica, ... Cell 179 (4), 880-894. e10, 2019 | 110 | 2019 |
Cytoplasmic amplification of transcriptional noise generates substantial cell-to-cell variability MMK Hansen, RV Desai, ML Simpson, LS Weinberger Cell systems 7 (4), 384-397. e6, 2018 | 103 | 2018 |
An HIV feedback resistor: auto-regulatory circuit deactivator and noise buffer LS Weinberger, T Shenk PLoS biology 5 (1), e9, 2007 | 97 | 2007 |
A post-transcriptional feedback mechanism for noise suppression and fate stabilization MMK Hansen, WY Wen, E Ingerman, BS Razooky, CE Thompson, RD Dar, ... Cell 173 (7), 1609-1621. e15, 2018 | 93 | 2018 |
A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions RV Desai, X Chen, B Martin, S Chaturvedi, DW Hwang, W Li, C Yu, ... Science 373 (6557), eabc6506, 2021 | 86 | 2021 |
Transcriptional bursting explains the noise–versus–mean relationship in mRNA and protein levels RD Dar, SM Shaffer, A Singh, BS Razooky, ML Simpson, A Raj, ... PloS one 11 (7), e0158298, 2016 | 82 | 2016 |
Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection LS Weinberger, DV Schaffer, AP Arkin Journal of virology 77 (18), 10028-10036, 2003 | 82 | 2003 |
Stochastic fate selection in HIV-infected patients AD Weinberger, LS Weinberger Cell 155 (3), 497-499, 2013 | 70 | 2013 |