| Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends and … Y Zhou, J Wang, Z Gu, S Wang, W Zhu, JL Aceña, VA Soloshonok, ... Chemical reviews 116 (2), 422-518, 2016 | 2657 | 2016 |
| Recent advances in the trifluoromethylation methodology and new CF3-containing drugs W Zhu, J Wang, S Wang, Z Gu, JL Aceña, K Izawa, H Liu, VA Soloshonok Journal of Fluorine Chemistry 167, 37-54, 2014 | 489 | 2014 |
| AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor F Ren, X Ding, M Zheng, M Korzinkin, X Cai, W Zhu, A Mantsyzov, ... Chemical Science 14 (6), 1443-1452, 2023 | 192 | 2023 |
| Nickel-Catalyzed ortho-C-H Thiolation of N-Benzoyl α-Amino Acid Derivatives F Gao, W Zhu, D Zhang, S Li, J Wang, H Liu The Journal of Organic Chemistry 81 (19), 9122-9130, 2016 | 62 | 2016 |
| Copper-mediated C–H (sp 2)/C–H (sp 3) coupling of benzoic acid derivatives with ethyl cyanoacetate: an expedient route to an isoquinolinone scaffold W Zhu, D Zhang, N Yang, H Liu Chemical Communications 50 (73), 10634-10636, 2014 | 58 | 2014 |
| Cu (II)-catalyzed C6-selective C–H thiolation of 2-pyridones using air as the oxidant P Peng, J Wang, C Li, W Zhu, H Jiang, H Liu RSC Advances 6 (62), 57441-57445, 2016 | 54 | 2016 |
| Highly Enantioselective Michael Addition of 2‐Oxindole‐ 3‐carboxylate Esters to Nitroolefins Promoted by Cinchona Alkaloid‐Thiourea‐Brønsted Acid Cocatalysts X Chen, W Zhu, W Qian, E Feng, Y Zhou, J Wang, H Jiang, ZJ Yao, H Liu Advanced Synthesis & Catalysis 354 (11‐12), 2151-2156, 2012 | 44 | 2012 |
| Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl α-Amino Acid Derivatives at Room Temperature S Li, W Zhu, F Gao, C Li, J Wang, H Liu The Journal of Organic Chemistry 82 (1), 126-134, 2017 | 31 | 2017 |
| Design, synthesis, and pharmacological evaluation of novel multisubstituted pyridin-3-amine derivatives as multitargeted protein kinase inhibitors for the treatment of non … W Zhu, H Chen, Y Wang, J Wang, X Peng, X Chen, Y Gao, C Li, Y He, J Ai, ... Journal of medicinal chemistry 60 (14), 6018-6035, 2017 | 30 | 2017 |
| Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors C Li, J Ai, D Zhang, X Peng, X Chen, Z Gao, Y Su, W Zhu, Y Ji, X Chen, ... ACS medicinal chemistry letters 6 (5), 507-512, 2015 | 29 | 2015 |
| A remarkable difference that one fluorine atom confers on the mechanisms of inactivation of human ornithine aminotransferase by two cyclohexene analogues of γ-aminobutyric acid W Zhu, PF Doubleday, DS Catlin, PM Weerawarna, A Butrin, S Shen, ... Journal of the American Chemical Society 142 (10), 4892-4903, 2020 | 28 | 2020 |
| Pd (ii)-catalyzed direct functionalization of C–H bonds of benzamides for synthesis of 1, 1-difluoro-1-alkenes C Li, D Zhang, W Zhu, P Wan, H Liu Organic Chemistry Frontiers 3 (9), 1080-1083, 2016 | 21 | 2016 |
| Structure–activity relationship study of indolin-5-yl-cyclopropanamine derivatives as selective lysine specific demethylase 1 (LSD1) inhibitors C Li, M Su, W Zhu, W Kan, T Ge, G Xu, S Wang, L Sheng, F Gao, Y Ye, ... Journal of Medicinal Chemistry 65 (5), 4335-4349, 2022 | 18 | 2022 |
| Rational design and development of novel CDK9 inhibitors for the treatment of acute myeloid leukemia X Han, N Song, A Saidahmatov, P Wang, Y Wang, X Hu, W Kan, W Zhu, ... Journal of Medicinal Chemistry 64 (19), 14647-14663, 2021 | 18 | 2021 |
| The facile construction of the phthalazin-1 (2H)-one scaffold via copper-mediated C–H (sp2)/C–H (sp) coupling under mild conditions W Zhu, B Wang, S Zhou, H Liu Beilstein Journal of Organic Chemistry 11 (1), 1624-1631, 2015 | 17 | 2015 |
| Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine … W Zhu, PF Doubleday, A Butrin, PM Weerawarna, RD Melani, DS Catlin, ... Journal of the American Chemical Society 143 (21), 8193-8207, 2021 | 15 | 2021 |
| Palladium‐Catalyzed C2‐Acylation of Indoles with α‐Diketones Assisted by the Removable N‐(2‐Pyrimidyl) Group C Li, W Zhu, S Shu, X Wu, H Liu European Journal of Organic Chemistry 2015 (17), 3743-3750, 2015 | 15 | 2015 |
| Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models W Zhu, X Liu, Q Li, F Gao, T Liu, X Chen, M Zhang, A Aliper, F Ren, ... Bioorganic & Medicinal Chemistry 91, 117414, 2023 | 13 | 2023 |
| Mechanism-based design of 3-amino-4-halocyclopentenecarboxylic acids as inactivators of GABA aminotransferase S Shen, PF Doubleday, PM Weerawarna, W Zhu, NL Kelleher, ... ACS Medicinal Chemistry Letters 11 (10), 1949-1955, 2020 | 13 | 2020 |
| Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation … W Zhu, A Butrin, RD Melani, PF Doubleday, GM Ferreira, MT Tavares, ... Journal of the American Chemical Society 144 (12), 5629-5642, 2022 | 9 | 2022 |