| Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance S Mok, EA Ashley, PE Ferreira, L Zhu, Z Lin, T Yeo, K Chotivanich, ... Science 347 (6220), 431-435, 2015 | 520 | 2015 |
| Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine LS Ross, SK Dhingra, S Mok, T Yeo, KJ Wicht, K Kümpornsin, ... Nature communications 9 (1), 1-13, 2018 | 239 | 2018 |
| Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness BH Stokes, SK Dhingra, K Rubiano, S Mok, J Straimer, NF Gnädig, I Deni, ... Elife 10, e66277, 2021 | 149 | 2021 |
| Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival S Mok, BH Stokes, NF Gnädig, LS Ross, T Yeo, C Amaratunga, E Allman, ... Nature communications 12 (1), 530, 2021 | 132 | 2021 |
| A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine SK Dhingra, D Redhi, JM Combrinck, T Yeo, J Okombo, PP Henrich, ... MBio 8 (3), 10.1128/mbio. 00303-17, 2017 | 113 | 2017 |
| Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity M Vanaerschot, JM Murithi, CFA Pasaje, S Ghidelli-Disse, L Dwomoh, ... Cell Chemical Biology, 2020 | 78 | 2020 |
| The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites E Yoo, CJ Schulze, BH Stokes, O Onguka, T Yeo, S Mok, NF Gnädig, ... Cell Chemical Biology 27 (2), 143-157. e5, 2020 | 60 | 2020 |
| Global spread of mutant PfCRT and its pleiotropic impact on Plasmodium falciparum multidrug resistance and fitness SK Dhingra, SJ Gabryszewski, JL Small-Saunders, T Yeo, PP Henrich, ... MBio 10 (2), 10.1128/mbio. 02731-18, 2019 | 47 | 2019 |
| A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin D Qiu, JV Pei, JEO Rosling, V Thathy, D Li, Y Xue, JD Tanner, ... Nature communications 13 (1), 5746, 2022 | 42 | 2022 |
| The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance JM Murithi, C Pascal, J Bath, X Boulenc, NF Gnädig, CFA Pasaje, ... Science Translational Medicine 13 (603), 2021 | 42 | 2021 |
| Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series MJ Palmer, X Deng, S Watts, G Krilov, A Gerasyuto, S Kokkonda, ... Journal of medicinal chemistry 64 (9), 6085-6136, 2021 | 37 | 2021 |
| Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum K Kümpornsin, T Kochakarn, T Yeo, J Okombo, MR Luth, J Hoshizaki, ... Nature Communications 14 (1), 3059, 2023 | 31 | 2023 |
| Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending … BE Barber, M Fernandez, HB Patel, C Barcelo, SD Woolley, H Patel, ... The Lancet Infectious Diseases 22 (6), 879-890, 2022 | 29 | 2022 |
| Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome SC Xie, RD Metcalfe, H Mizutani, T Puhalovich, E Hanssen, CJ Morton, ... Proceedings of the National Academy of Sciences 118 (39), e2107213118, 2021 | 29 | 2021 |
| Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 LE de Vries, PAM Jansen, C Barcelo, J Munro, JMJ Verhoef, CFA Pasaje, ... Nature communications 13 (1), 2158, 2022 | 28 | 2022 |
| Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 MA Lowe, A Cardenas, JP Valentin, Z Zhu, J Abendroth, JL Castro, ... Journal of medicinal chemistry 65 (20), 14121-14143, 2022 | 24 | 2022 |
| Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness S Mok, T Yeo, D Hong, MJ Shears, LS Ross, KE Ward, SK Dhingra, ... Science Advances 9 (45), eadi2364, 2023 | 23 | 2023 |
| The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance JM Murithi, I Deni, CFA Pasaje, J Okombo, JL Bridgford, NF Gnädig, ... Cell chemical biology 29 (5), 824-839. e6, 2022 | 22 | 2022 |
| Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites D Dorjsuren, RT Eastman, KJ Wicht, D Jansen, DC Talley, BA Sigmon, ... Scientific reports 11 (1), 1-16, 2021 | 22 | 2021 |
| Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors M Okaniwa, A Shibata, A Ochida, Y Akao, KL White, DM Shackleford, ... ACS infectious diseases 7 (6), 1680-1689, 2021 | 21 | 2021 |