| A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M 2+ ) M Hollenstein, CJ Hipolito, CH Lam, DM Perrin Nucleic acids research 37 (5), 1638-1649, 2009 | 143 | 2009 |
| A DNAzyme with Three Protein‐Like Functional Groups: Enhancing Catalytic Efficiency of M2+‐Independent RNA Cleavage M Hollenstein, CJ Hipolito, CH Lam, DM Perrin ChemBioChem 10 (12), 1988-1992, 2009 | 95 | 2009 |
| A densely modified M 2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover Y Wang, E Liu, CH Lam, DM Perrin Chemical Science 9 (7), 1813-1821, 2018 | 79 | 2018 |
| Toward the combinatorial selection of chemically modified DNAzyme RNase A mimics active against all-RNA substrates M Hollenstein, CJ Hipolito, CH Lam, DM Perrin ACS combinatorial science 15 (4), 174-182, 2013 | 71 | 2013 |
| Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity R Dolot, CH Lam, M Sierant, Q Zhao, FW Liu, B Nawrot, M Egli, X Yang Nucleic acids research 46 (9), 4819-4830, 2018 | 70 | 2018 |
| Whole cell-SELEX of aptamers with a tyrosine-like side chain against live bacteria M Renders, E Miller, CH Lam, DM Perrin Organic & biomolecular chemistry 15 (9), 1980-1989, 2017 | 50 | 2017 |
| X-aptamer selection and validation GL Lokesh, H Wang, CH Lam, V Thiviyanathan, N Ward, DG Gorenstein, ... RNA Nanostructures: Methods and Protocols, 151-174, 2017 | 48 | 2017 |
| Selection of pd1/pd-l1 x-aptamers H Wang, CH Lam, X Li, DL West, X Yang Biochimie 145, 125-130, 2018 | 41 | 2018 |
| Introduction of guanidinium-modified deoxyuridine into the substrate binding regions of DNAzyme 10–23 to enhance target affinity: implications for DNAzyme design CH Lam, DM Perrin Bioorganic & medicinal chemistry letters 20 (17), 5119-5122, 2010 | 36 | 2010 |
| Protein-inspired modified DNAzymes: Dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes CJ Hipolito, M Hollenstein, CH Lam, DM Perrin Organic & biomolecular chemistry 9 (7), 2266-2273, 2011 | 32 | 2011 |
| A divalent metal-dependent self-cleaving DNAzyme with a tyrosine side chain CH Lam, CJ Hipolito, M Hollenstein, DM Perrin Organic & biomolecular chemistry 9 (20), 6949-6954, 2011 | 31 | 2011 |
| Synthesis and enzymatic incorporation of modified deoxyadenosine triphosphates C Lam, C Hipolito, DM Perrin European Journal of Organic Chemistry 2008 (29), 4915-4923, 2008 | 28 | 2008 |
| Systematic study of constraints imposed by modified nucleoside triphosphates with protein-like side chains for use in in vitro selection Y Wang, N Ng, E Liu, CH Lam, DM Perrin Organic & Biomolecular Chemistry 15 (3), 610-618, 2017 | 16 | 2017 |
| Synthesis and enzymatic incorporation of modified deoxyuridine triphosphates E Liu, CH Lam, DM Perrin Molecules 20 (8), 13591-13602, 2015 | 15 | 2015 |
| Expanding the chemical diversity of DNA C Guo, D Kong, Y Lei, R Hili Synlett 29 (11), 1405-1414, 2018 | 6 | 2018 |
| In vitro selection of a DNAzyme with three modified nucleotides M Hollenstein, C Hipolito, C Lam, D Perrin Nucleic Acids Symposium Series 52 (1), 73-74, 2008 | 5 | 2008 |
| 140. Non-SELEX bead-based X-Aptamer selection CH Lam, NE Ward, J Englehardt Molecular Therapy 23, S57, 2015 | 4 | 2015 |
| The design of an X-aptamer against snake venom disintegrins I Diego, M Suntravat, SE Lucena, C Lam, N Ward, M Shumbera, ... Toxicon 158, S51-S51, 2019 | 1 | 2019 |
| Titelbild: A Highly Selective DNAzyme Sensor for Mercuric Ions (Angew. Chem. 23/2008) M Hollenstein, C Hipolito, C Lam, D Dietrich, DM Perrin Angewandte Chemie 120 (23), 4307-4307, 2008 | 1 | 2008 |
| Cover Picture: A Highly Selective DNAzyme Sensor for Mercuric Ions (Angew. Chem. Int. Ed. 23/2008) M Hollenstein, C Hipolito, C Lam, D Dietrich, DM Perrin Angewandte Chemie International Edition 47 (23), 4239-4239, 2008 | 1 | 2008 |
