| TGF-β: duality of function between tumor prevention and carcinogenesis DR Principe, JA Doll, J Bauer, B Jung, HG Munshi, L Bartholin, B Pasche, ... Journal of the National Cancer Institute 106 (2), djt369, 2014 | 589 | 2014 |
| The current treatment paradigm for pancreatic ductal adenocarcinoma and barriers to therapeutic efficacy DR Principe, PW Underwood, M Korc, JG Trevino, HG Munshi, A Rana Frontiers in Oncology 11, 688377, 2021 | 206 | 2021 |
| TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis DR Principe, B DeCant, E Mascariñas, EA Wayne, AM Diaz, N Akagi, ... Cancer research 76 (9), 2525-2539, 2016 | 206 | 2016 |
| The oncopig cancer model: an innovative large animal translational oncology platform KM Schachtschneider, RM Schwind, J Newson, N Kinachtchouk, M Rizko, ... Frontiers in oncology 7, 190, 2017 | 131 | 2017 |
| SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth SH Park, O Ozden, G Liu, HY Song, Y Zhu, Y Yan, X Zou, HJ Kang, ... Cancer research 76 (13), 3802-3812, 2016 | 125 | 2016 |
| TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell–Mediated Regression of Pancreatic Cancer DR Principe, A Park, MJ Dorman, S Kumar, N Viswakarma, J Rubin, ... Molecular cancer therapeutics 18 (3), 613-620, 2019 | 119 | 2019 |
| Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy DR Principe, M Narbutis, S Kumar, A Park, N Viswakarma, MJ Dorman, ... Cancer research 80 (15), 3101-3115, 2020 | 108 | 2020 |
| SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis Y Zhu, Y Yan, DR Principe, X Zou, A Vassilopoulos, D Gius Cancer & metabolism 2, 1-11, 2014 | 79 | 2014 |
| TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function DR Principe, AM Diaz, C Torres, RJ Mangan, B DeCant, R McKinney, ... Oncogene 36 (30), 4336-4348, 2017 | 76 | 2017 |
| Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer J Bauer, O Ozden, N Akagi, T Carroll, DR Principe, JJ Staudacher, ... Molecular cancer 14, 1-14, 2015 | 72 | 2015 |
| Regulatory T-cells as an emerging barrier to immune checkpoint inhibition in lung cancer DR Principe, L Chiec, NA Mohindra, HG Munshi Frontiers in oncology 11, 684098, 2021 | 71 | 2021 |
| Trials and tribulations of pancreatic cancer immunotherapy DR Principe, M Korc, SD Kamath, HG Munshi, A Rana Cancer letters 504, 1-14, 2021 | 69 | 2021 |
| A validated, transitional and translational porcine model of hepatocellular carcinoma KM Schachtschneider, RM Schwind, KA Darfour-Oduro, K De Arun, ... Oncotarget 8 (38), 63620, 2017 | 67 | 2017 |
| Of mice, dogs, pigs, and men: choosing the appropriate model for immuno-oncology research NH Overgaard, TM Fan, KM Schachtschneider, DR Principe, LB Schook, ... ILAR journal 59 (3), 247-262, 2018 | 57 | 2018 |
| TGFβ signaling in the pancreatic tumor microenvironment DR Principe, KE Timbers, LG Atia, RM Koch, A Rana Cancers 13 (20), 5086, 2021 | 56 | 2021 |
| The immune modifying effects of chemotherapy and advances in chemo-immunotherapy DR Principe, SD Kamath, M Korc, HG Munshi Pharmacology & therapeutics 236, 108111, 2022 | 49 | 2022 |
| Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation DR Principe, B DeCant, J Staudacher, D Vitello, RJ Mangan, EA Wayne, ... Oncotarget 8 (3), 3826, 2016 | 48 | 2016 |
| The difficulty in translating the preclinical success of combined TGFβ and immune checkpoint inhibition to clinical trial AE Metropulos, HG Munshi, DR Principe EBioMedicine 86, 2022 | 47 | 2022 |
| Preclinical models of pancreatic ductal adenocarcinoma and their utility in immunotherapy studies TND Pham, MA Shields, C Spaulding, DR Principe, B Li, PW Underwood, ... Cancers 13 (3), 440, 2021 | 47 | 2021 |
| HDAC3 mediates smoking-induced pancreatic cancer M Edderkaoui, S Xu, C Chheda, S Morvaridi, RW Hu, PJ Grippo, ... Oncotarget 7 (7), 7747, 2016 | 47 | 2016 |
