Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ... Nature medicine 25 (4), 628-640, 2019 | 659 | 2019 |
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, ... Cancer discovery 10 (1), 104-123, 2020 | 188 | 2020 |
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling H Kang, Z Hong, M Zhong, J Klomp, KJ Bayless, D Mehta, AV Karginov, ... American Journal of Physiology-Cell Physiology 316 (1), C92-C103, 2019 | 141 | 2019 |
Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae AM Zimnicka, YS Husain, AN Shajahan, M Sverdlov, O Chaga, Z Chen, ... Molecular biology of the cell 27 (13), 2090-2106, 2016 | 130 | 2016 |
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy M Holderfield, BJ Lee, J Jiang, A Tomlinson, KJ Seamon, A Mira, ... Nature 629 (8013), 919-926, 2024 | 105 | 2024 |
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer CM Goodwin, AM Waters, JE Klomp, S Javaid, KL Bryant, CA Stalnecker, ... Cancer research 83 (1), 141-157, 2023 | 88 | 2023 |
Cloacal microbial communities of female spotted towhees Pipilo maculatus: microgeographic variation and individual sources of variability JE Klomp, MT Murphy, SB Smith, JE McKay, I Ferrera, AL Reysenbach Journal of Avian Biology 39 (5), 530-538, 2008 | 57 | 2008 |
The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction JE Klomp, JA Klomp, CJ Der Biochemical society transactions 49 (1), 253-267, 2021 | 54 | 2021 |
Transcriptional coactivators are not required for herpes simplex virus type 1 immediate-early gene expression in vitro SB Kutluay, SL DeVos, JE Klomp, SJ Triezenberg Journal of virology 83 (8), 3436-3449, 2009 | 45 | 2009 |
TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors AC Edwards, CA Stalnecker, A Jean Morales, KE Taylor, JE Klomp, ... Cancer research 83 (24), 4112-4129, 2023 | 34 | 2023 |
Time-variant SRC kinase activation determines endothelial permeability response JE Klomp, M Shaaya, J Matsche, R Rebiai, JS Aaron, KB Collins, V Huyot, ... Cell chemical biology 26 (8), 1081-1094. e6, 2019 | 32 | 2019 |
Defining the KRAS-and ERK-dependent transcriptome in KRAS-mutant cancers JA Klomp, JE Klomp, CA Stalnecker, KL Bryant, AC Edwards, ... Science 384 (6700), eadk0775, 2024 | 29 | 2024 |
CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment JE Klomp, YS Lee, CM Goodwin, B Papke, JA Klomp, AM Waters, ... Cell reports 37 (9), 2021 | 26 | 2021 |
Targeting p130Cas-and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition AM Waters, TO Khatib, B Papke, CM Goodwin, GA Hobbs, JN Diehl, ... Cell reports 35 (13), 2021 | 25 | 2021 |
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer JN Diehl, JE Klomp, KR Snare, PS Hibshman, DR Blake, ZD Kaiser, ... Journal of Biological Chemistry 297 (5), 101335, 2021 | 23 | 2021 |
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer JE Klomp, JN Diehl, JA Klomp, AC Edwards, R Yang, AJ Morales, ... Science 384 (6700), eadk0850, 2024 | 22 | 2024 |
Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis KB Collins, H Kang, J Matsche, JE Klomp, J Rehman, AB Malik, ... Journal of Cell Biology 219 (2), e201903023, 2019 | 19 | 2019 |
Mimicking transient activation of protein kinases in living cells JE Klomp, V Huyot, AM Ray, KB Collins, AB Malik, AV Karginov Proceedings of the National Academy of Sciences 113 (52), 14976-14981, 2016 | 18 | 2016 |
Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells J Klomp, J Hyun, JE Klomp, K Pajcini, J Rehman, AB Malik Journal of Biological Chemistry 295 (15), 4796-4808, 2020 | 17 | 2020 |
Noncanonical function of long myosin light chain kinase in increasing ER‐PM junctions and augmentation of SOCE N Srivastava, M Tauseef, R Amin, B Joshi, JC Joshi, V Kini, J Klomp, W Li, ... The FASEB Journal 34 (9), 12805-12819, 2020 | 5 | 2020 |