| Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects J Mertens, ACM Paquola, M Ku, E Hatch, L Böhnke, S Ladjevardi, ... Cell stem cell 17 (6), 705-718, 2015 | 746 | 2015 |
| Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS A Jovičić, J Mertens, S Boeynaems, E Bogaert, N Chai, SB Yamada, ... Nature neuroscience 18 (9), 1226-1229, 2015 | 687 | 2015 |
| Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation X Zheng, L Boyer, M Jin, J Mertens, Y Kim, L Ma, L Ma, M Hamm, ... elife 5, e13374, 2016 | 651 | 2016 |
| Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder J Mertens, QW Wang, Y Kim, DX Yu, S Pham, B Yang, Y Zheng, ... Nature 527 (7576), 95-99, 2015 | 569 | 2015 |
| Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ... Neuron 99 (5), 925-940. e7, 2018 | 445 | 2018 |
| Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro C Bardy, M Van Den Hurk, T Eames, C Marchand, M Hernandez, ... Proceedings of the National Academy of Sciences of the United States of …, 2015 | 431 | 2015 |
| Small molecules enable highly efficient neuronal conversion of human fibroblasts J Ladewig, J Mertens, J Kesavan, J Doerr, D Poppe, F Glaue, S Herms, ... Nature methods 9 (6), 575-578, 2012 | 391 | 2012 |
| Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease P Koch, P Breuer, M Peitz, J Jungverdorben, J Kesavan, D Poppe, J Doerr, ... Nature 480 (7378), 543-546, 2011 | 377 | 2011 |
| Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience J Mertens, MC Marchetto, C Bardy, FH Gage Nature Reviews Neuroscience 17 (7), 424-437, 2016 | 350 | 2016 |
| Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons ST Schafer, ACM Paquola, S Stern, D Gosselin, M Ku, M Pena, TJM Kuret, ... Nature neuroscience 22 (2), 243-255, 2019 | 261 | 2019 |
| Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases J Mertens, D Reid, S Lau, Y Kim, FH Gage Annual review of genetics 52 (1), 271-293, 2018 | 261 | 2018 |
| Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients J Mertens, JR Herdy, L Traxler, ST Schafer, JCM Schlachetzki, L Böhnke, ... Cell stem cell 28 (9), 1533-1548. e6, 2021 | 199 | 2021 |
| Generation of functional human serotonergic neurons from fibroblasts KC Vadodaria, J Mertens, A Paquola, C Bardy, X Li, R Jappelli, L Fung, ... Molecular psychiatry 21 (1), 49-61, 2016 | 141 | 2016 |
| Presenilin-1 L166P mutant human pluripotent stem cell–derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation P Koch, IY Tamboli, J Mertens, P Wunderlich, J Ladewig, K Stüber, ... The American journal of pathology 180 (6), 2404-2416, 2012 | 141 | 2012 |
| Mitochondrial aging defects emerge in directly reprogrammed human neurons due to their metabolic profile Y Kim, X Zheng, Z Ansari, MC Bunnell, JR Herdy, L Traxler, H Lee, ... Cell reports 23 (9), 2550-2558, 2018 | 131 | 2018 |
| Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells T Toda, JY Hsu, SB Linker, L Hu, ST Schafer, J Mertens, FV Jacinto, ... Cell stem cell 21 (5), 618-634. e7, 2017 | 127 | 2017 |
| Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease L Traxler, JR Herdy, D Stefanoni, S Eichhorner, S Pelucchi, A Szücs, ... Cell metabolism 34 (9), 1248-1263. e6, 2022 | 106 | 2022 |
| Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease JR Herdy, L Traxler, RK Agarwal, L Karbacher, JCM Schlachetzki, ... Cell stem cell 29 (12), 1637-1652. e6, 2022 | 100 | 2022 |
| APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation J Mertens, K Stüber, P Wunderlich, J Ladewig, JC Kesavan, ... Stem Cell Reports 1 (6), 491-498, 2013 | 88 | 2013 |
| The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample KJ Oedegaard, M Alda, A Anand, OA Andreassen, Y Balaraman, ... BMC psychiatry 16, 1-15, 2016 | 86 | 2016 |
Rusty GageThe Salk InstituteПотвърден имейл адрес: salk.edu
