| Master transcription factors and mediator establish super-enhancers at key cell identity genes WA Whyte, DA Orlando, D Hnisz, BJ Abraham, CY Lin, MH Kagey, ... Cell 153 (2), 307-319, 2013 | 4077 | 2013 |
| Selective inhibition of tumor oncogenes by disruption of super-enhancers J Lovén, HA Hoke, CY Lin, A Lau, DA Orlando, CR Vakoc, JE Bradner, ... Cell 153 (2), 320-334, 2013 | 2995 | 2013 |
| Mediator and cohesin connect gene expression and chromatin architecture MH Kagey, JJ Newman, S Bilodeau, Y Zhan, DA Orlando, NL van Berkum, ... Nature 467 (7314), 430-435, 2010 | 2296 | 2010 |
| A high-resolution root spatiotemporal map reveals dominant expression patterns SM Brady, DA Orlando, JY Lee, JY Wang, J Koch, JR Dinneny, D Mace, ... Science 318 (5851), 801-806, 2007 | 1272 | 2007 |
| Revisiting global gene expression analysis J Lovén, DA Orlando, AA Sigova, CY Lin, PB Rahl, CB Burge, DL Levens, ... Cell 151 (3), 476-482, 2012 | 724 | 2012 |
| Master transcription factors determine cell-type-specific responses to TGF-β signaling AC Mullen, DA Orlando, JJ Newman, J Lovén, RM Kumar, S Bilodeau, ... Cell 147 (3), 565-576, 2011 | 704 | 2011 |
| Enhancer decommissioning by LSD1 during embryonic stem cell differentiation WA Whyte, S Bilodeau, DA Orlando, HA Hoke, GM Frampton, CT Foster, ... Nature 482 (7384), 221-225, 2012 | 668 | 2012 |
| The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset CJ Ceol, Y Houvras, J Jane-Valbuena, S Bilodeau, DA Orlando, V Battisti, ... Nature 471 (7339), 513-517, 2011 | 638 | 2011 |
| Quantitative ChIP-Seq normalization reveals global modulation of the epigenome DA Orlando, MW Chen, VE Brown, S Solanki, YJ Choi, ER Olson, CC Fritz, ... Cell reports 9 (3), 1163-1170, 2014 | 540 | 2014 |
| Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells AA Sigova, AC Mullen, B Molinie, S Gupta, DA Orlando, MG Guenther, ... Proceedings of the National Academy of Sciences 110 (8), 2876-2881, 2013 | 520 | 2013 |
| Global control of cell-cycle transcription by coupled CDK and network oscillators DA Orlando, CY Lin, A Bernard, JY Wang, JES Socolar, ES Iversen, ... Nature 453 (7197), 944-947, 2008 | 396 | 2008 |
| Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons Y Li, H Wang, J Muffat, AW Cheng, DA Orlando, J Lovén, S Kwok, ... Cell stem cell 13 (4), 446-458, 2013 | 364 | 2013 |
| Superenhancer analysis defines novel epigenomic subtypes of non-APL AML, including an RARα dependency targetable by SY-1425, a potent and selective RARα agonist MR McKeown, MR Corces, ML Eaton, C Fiore, E Lee, JT Lopez, ... Cancer discovery 7 (10), 1136-1153, 2017 | 143 | 2017 |
| Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7 S Hu, JJ Marineau, N Rajagopal, KB Hamman, YJ Choi, DR Schmidt, ... Cancer research 79 (13), 3479-3491, 2019 | 139 | 2019 |
| Protonophore‐and pH‐insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips B Chaudhuri, F Hörmann, S Lalonde, SM Brady, DA Orlando, P Benfey, ... The Plant Journal 56 (6), 948-962, 2008 | 136 | 2008 |
| Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements JM Dowen, S Bilodeau, DA Orlando, MR Hübner, BJ Abraham, ... Stem cell reports 1 (5), 371-378, 2013 | 134 | 2013 |
| Cyclin-Dependent Kinases Are Regulators and Effectors of Oscillations Driven by a Transcription Factor Network LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ... Molecular Cell 49 (6), 1177-1179, 2013 | 85 | 2013 |
| Transcription network and cyclin/CDKs: The yin and yang of cell cycle oscillators LAS Kovacs, DA Orlando, SB Haase Cell cycle 7 (17), 2626-2629, 2008 | 65 | 2008 |
| Reconstructing spatiotemporal gene expression data from partial observations DA Cartwright, SM Brady, DA Orlando, B Sturmfels, PN Benfey Bioinformatics 25 (19), 2581-2587, 2009 | 60 | 2009 |
| CpG island structure and trithorax/polycomb chromatin domains in human cells DA Orlando, MG Guenther, GM Frampton, RA Young Genomics 100 (5), 320-326, 2012 | 49 | 2012 |
Richard YoungProfessor of Biology, MITПотвърден имейл адрес: wi.mit.edu
