Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer S Krishna, FJ Lowery, AR Copeland, E Bahadiroglu, R Mukherjee, L Jia, ... Science 370 (6522), 1328-1334, 2020 | 442 | 2020 |
Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers FJ Lowery, S Krishna, R Yossef, NB Parikh, PD Chatani, N Zacharakis, ... Science 375 (6583), 877-884, 2022 | 289 | 2022 |
TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes D Chowell, S Krishna, PD Becker, C Cocita, J Shu, X Tan, PD Greenberg, ... Proceedings of the National Academy of Sciences 112 (14), E1754-E1762, 2015 | 264 | 2015 |
Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes SR Ferdosi, R Ewaisha, F Moghadam, S Krishna, JG Park, ... Nature communications 10 (1), 1842, 2019 | 193 | 2019 |
Multi-phenotype CRISPR-Cas9 screen identifies p38 kinase as a target for adoptive immunotherapies D Gurusamy, AN Henning, TN Yamamoto, Z Yu, N Zacharakis, S Krishna, ... Cancer cell 37 (6), 818-833. e9, 2020 | 148 | 2020 |
A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers K Hanada, C Zhao, R Gil-Hoyos, JJ Gartner, C Chow-Parmer, FJ Lowery, ... Cancer Cell 40 (5), 479-493. e6, 2022 | 127 | 2022 |
Adoptive cellular therapy with autologous tumor-infiltrating lymphocytes and T-cell receptor–engineered T cells targeting common p53 neoantigens in human solid tumors SP Kim, NR Vale, N Zacharakis, S Krishna, Z Yu, B Gasmi, JJ Gartner, ... Cancer immunology research 10 (8), 932-946, 2022 | 117 | 2022 |
Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer S Krishna, P Ulrich, E Wilson, F Parikh, P Narang, S Yang, AK Read, ... Cancer research 78 (21), 6159-6170, 2018 | 80 | 2018 |
A machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types JJ Gartner, MR Parkhurst, A Gros, E Tran, MS Jafferji, A Copeland, ... Nature cancer 2 (5), 563-574, 2021 | 67 | 2021 |
Modelling the effect of early detection of Ebola D Chowell, C Castillo-Chavez, S Krishna, X Qiu, KS Anderson The Lancet Infectious Diseases 15 (2), 148-149, 2015 | 66 | 2015 |
JAK2 and PD-L1 amplification enhance the dynamic expression of PD-L1 in triple-negative breast cancer M Chen, B Pockaj, M Andreozzi, MT Barrett, S Krishna, S Eaton, R Niu, ... Clinical breast cancer 18 (5), e1205-e1215, 2018 | 64 | 2018 |
Neoantigen identification and response to adoptive cell transfer in anti–PD-1 naïve and experienced patients with metastatic melanoma ST Levi, AR Copeland, S Nah, JS Crystal, GD Ivey, A Lalani, M Jafferji, ... Clinical cancer research 28 (14), 3042-3052, 2022 | 39 | 2022 |
Phenotypic signatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers R Yossef, S Krishna, S Sindiri, FJ Lowery, AR Copeland, JJ Gartner, ... Cancer Cell 41 (12), 2154-2165. e5, 2023 | 29 | 2023 |
Rapid identification and evaluation of neoantigen-reactive T-cell receptors from single cells BC Paria, N Levin, FJ Lowery, A Pasetto, DC Deniger, MR Parkhurst, ... Journal of Immunotherapy 44 (1), 1-8, 2021 | 27 | 2021 |
T-cell epitope discovery for therapeutic cancer vaccines S Krishna, KS Anderson Vaccine Design: Methods and Protocols: Volume 1: Vaccines for Human Diseases …, 2016 | 20 | 2016 |
Cell surface marker-based capture of neoantigen-reactive CD8+ T-cell receptors from metastatic tumor digests PD Chatani, FJ Lowery, NB Parikh, KJ Hitscherich, R Yossef, V Hill, ... Journal for ImmunoTherapy of Cancer 11 (5), e006264, 2023 | 17 | 2023 |
High throughput identification of t-cell recognition antigens and epitopes J Labaer, K Anderson, J Qiu, S Krishna US Patent App. 15/770,323, 2018 | 17 | 2018 |
Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results M Parkhurst, SL Goff, FJ Lowery, RK Beyer, H Halas, PF Robbins, ... Nature Medicine 30 (9), 2586-2595, 2024 | 13 | 2024 |
Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes N Levin, SP Kim, CA Marquardt, NR Vale, Z Yu, S Sindiri, JJ Gartner, ... Journal for ImmunoTherapy of Cancer 12 (5), e008645, 2024 | 6 | 2024 |
Modulating human Cas9-specific host immune response R Ewaisha, S Kiani, SR Ferdosi, K Anderson, F Moghadam, S Krishna, ... US Patent 11,208,640, 2021 | 4 | 2021 |