| SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner P Rada, AI Rojo, S Chowdhry, M McMahon, JD Hayes, A Cuadrado Molecular and cellular biology 31 (6), 1121-1133, 2011 | 852 | 2011 |
| Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity S Chowdhry, Y Zhang, M McMahon, C Sutherland, A Cuadrado, ... Oncogene 32 (32), 3765-3781, 2013 | 710 | 2013 |
| Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway JD Hayes, M McMahon, S Chowdhry, AT Dinkova-Kostova Antioxidants & redox signaling 13 (11), 1713-1748, 2010 | 641 | 2010 |
| Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis S Chowdhry, MH Nazmy, PJ Meakin, AT Dinkova-Kostova, SV Walsh, ... Free Radical Biology and Medicine 48 (2), 357-371, 2010 | 317 | 2010 |
| Altered cellular metabolism in gliomas—An emerging landscape of actionable co-dependency targets J Bi, S Chowdhry, S Wu, W Zhang, K Masui, PS Mischel Nature Reviews Cancer 20 (1), 57-70, 2020 | 295 | 2020 |
| Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein … PJ Meakin, S Chowdhry, RS Sharma, FB Ashford, SV Walsh, ... Molecular and cellular biology 34 (17), 3305-3320, 2014 | 251 | 2014 |
| NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling S Chowdhry, C Zanca, U Rajkumar, T Koga, Y Diao, R Raviram, F Liu, ... Nature 569 (7757), 570-575, 2019 | 213 | 2019 |
| Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 KFS Bell, B Al-Mubarak, MA Martel, S McKay, N Wheelan, P Hasel, ... Nature Communications 6 (1), 7066, 2015 | 192 | 2015 |
| Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling J Bi, TA Ichu, C Zanca, H Yang, W Zhang, Y Gu, S Chowdhry, A Reed, ... Cell metabolism 30 (3), 525-538. e8, 2019 | 180 | 2019 |
| Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3 JD Hayes, S Chowdhry, AT Dinkova-Kostova, C Sutherland Biochemical Society Transactions 43 (4), 611-620, 2015 | 180 | 2015 |
| Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning KF Bell, B Al-Mubarak, JH Fowler, PS Baxter, K Gupta, T Tsujita, ... Proceedings of the National Academy of Sciences 108 (1), E1-E2, 2011 | 164 | 2011 |
| Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses L Torrente, C Sanchez, R Moreno, S Chowdhry, P Cabello, K Isono, ... Oncogene 36 (44), 6204-6212, 2017 | 101 | 2017 |
| Heat shock factor 1 is a substrate for p38 mitogen-activated protein kinases S Dayalan Naidu, C Sutherland, Y Zhang, A Risco, L de la Vega, ... Molecular and cellular biology 36 (18), 2403-2417, 2016 | 89 | 2016 |
| Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer R Yaeger, R Mezzadra, J Sinopoli, Y Bian, M Marasco, E Kaplun, Y Gao, ... Cancer discovery 13 (1), 41-55, 2023 | 73 | 2023 |
| Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress BR Al-Mubarak, KFS Bell, S Chowdhry, PJ Meakin, PS Baxter, S McKay, ... Redox biology 47, 102158, 2021 | 31 | 2021 |
| Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes RF Deighton, NM Márkus, B Al-Mubarak, KFS Bell, S Papadia, PJ Meakin, ... Proceedings of the National Academy of Sciences 111 (18), E1818-E1820, 2014 | 31 | 2014 |
| Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP JD Hayes, K Ebisine, RS Sharma, S Chowdhry, AT Dinkova-Kostova, ... Current Opinion in Toxicology 1, 92-103, 2016 | 22 | 2016 |
| Enhancing transcription–replication conflict targets ecDNA-positive cancers J Tang, NE Weiser, G Wang, S Chowdhry, EJ Curtis, Y Zhao, ITL Wong, ... Nature 635 (8037), 210-218, 2024 | 7 | 2024 |
| tumors driven by oncogene amplified extrachromosomal DNA (ecDNA) demonstrate enhanced sensitivity to cell cycle checkpoint kinase 1 (CHK1) inhibition S Chowdhry, S Milutinovic, E Tse, S Garcia, D Perusse, M Ritland, J Ko, ... Cancer Research 83 (7_Supplement), 1626-1626, 2023 | 5 | 2023 |
| Replication stress and the inability to repair damaged DNA, the potential “Achilles' heel” of ecDNA+ tumor cells S Chowdhry, S Garcia, NP Nguyen, A Celeste, E Tse, S Milutinovic, ... Cancer Research 82 (12_Supplement), 1520-1520, 2022 | 4 | 2022 |