The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ... British journal of pharmacology 178, S27-S156, 2021 | 1310 | 2021 |
The complement receptor C5aR2: a powerful modulator of innate and adaptive immunity XX Li, JD Lee, C Kemper, TM Woodruff The Journal of Immunology 202 (12), 3339-3348, 2019 | 137 | 2019 |
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein EA Albornoz, AA Amarilla, N Modhiran, S Parker, XX Li, DK Wijesundara, ... Molecular psychiatry 28 (7), 2878-2893, 2023 | 127 | 2023 |
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors S Pandey, P Kumari, M Baidya, R Kise, Y Cao, H Dwivedi-Agnihotri, ... Molecular cell 81 (22), 4605-4621. e11, 2021 | 93 | 2021 |
Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2 FH Brennan, T Jogia, ER Gillespie, LV Blomster, XX Li, B Nowlan, ... JCI insight 4 (9), e98254, 2019 | 89 | 2019 |
New concepts on the therapeutic control of complement anaphylatoxin receptors OA Hawksworth, XX Li, LG Coulthard, EJ Wolvetang, TM Woodruff Molecular immunology 89, 36-43, 2017 | 85 | 2017 |
Emerging insights into the structure and function of complement C5a receptors S Pandey, J Maharana, XX Li, TM Woodruff, AK Shukla Trends in Biochemical Sciences 45 (8), 693-705, 2020 | 81 | 2020 |
Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function XX Li, JD Lee, NL Massey, C Guan, AAB Robertson, RJ Clark, ... Biochemical pharmacology 180, 114156, 2020 | 60 | 2020 |
C5aR2 activation broadly modulates the signaling and function of primary human macrophages XX Li, RJ Clark, TM Woodruff The Journal of Immunology 205 (4), 1102-1112, 2020 | 48 | 2020 |
Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1 S Pandey, XX Li, A Srivastava, M Baidya, P Kumari, H Dwivedi, ... Journal of Biological Chemistry 294 (24), 9416-9429, 2019 | 38 | 2019 |
C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma JA Nabizadeh, HD Manthey, N Panagides, FJ Steyn, JD Lee, XX Li, ... The FASEB Journal 33 (10), 11060-11071, 2019 | 31 | 2019 |
Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors MK Yadav, J Maharana, R Yadav, S Saha, P Sarma, C Soni, V Singh, ... Cell 186 (22), 4956-4973. e21, 2023 | 27 | 2023 |
The “C3aR antagonist” SB290157 is a partial C5aR2 agonist XX Li, V Kumar, RJ Clark, JD Lee, TM Woodruff Frontiers in pharmacology 11, 591398, 2021 | 27 | 2021 |
Development of potent and selective agonists for complement C5a receptor 1 with in vivo activity DM Gorman, XX Li, JD Lee, JN Fung, CS Cui, HS Lee, BE Rolfe, ... Journal of Medicinal Chemistry 64 (22), 16598-16608, 2021 | 11 | 2021 |
Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists XX Li, RJ Clark, TM Woodruff International Immunopharmacology 100, 108074, 2021 | 9 | 2021 |
Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing XX Li, JN Fung, RJ Clark, JD Lee, TM Woodruff Proceedings of the National Academy of Sciences 121 (5), e2314627121, 2024 | 7 | 2024 |
Optimisation of a Microfluidic Method for the Delivery of a Small Peptide FY Han, W Xu, V Kumar, CS Cui, X Li, X Jiang, TM Woodruff, AK Whittaker, ... Pharmaceutics 13 (9), 1505, 2021 | 6 | 2021 |
TLQP-21 is a low potency partial C3aR activator on human primary macrophages XX Li, JD Lee, HS Lee, RJ Clark, TM Woodruff Frontiers in Immunology 14, 1086673, 2023 | 5 | 2023 |
Development of Synthetic Human and Mouse C5a: Application to Binding and Functional Assays In Vitro and In Vivo DM Gorman, XX Li, CD Payne, CS Cui, JD Lee, KJ Rosengren, ... ACS Pharmacology & Translational Science 4 (6), 1808-1817, 2021 | 4 | 2021 |
Unexpected off-target activities for recombinant C5a in human macrophages XX Li, DM Gorman, JD Lee, RJ Clark, TM Woodruff The Journal of Immunology 208 (1), 133-142, 2022 | 3 | 2022 |