Следене
Carl Ward
Carl Ward
Gladstone Institutes
Потвърден имейл адрес: gladstone.ucsf.edu
Заглавие
Позовавания
Позовавания
Година
Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state
L Magtanong, PJ Ko, M To, JY Cao, GC Forcina, A Tarangelo, CC Ward, ...
Cell chemical biology 26 (3), 420-432. e9, 2019
8442019
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
JN Spradlin, X Hu, CC Ward, SM Brittain, MD Jones, L Ou, M To, ...
Nature chemical biology 15 (7), 747-755, 2019
3702019
Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications
CC Ward, JI Kleinman, SM Brittain, PS Lee, CYS Chung, K Kim, Y Petri, ...
ACS chemical biology 14 (11), 2430-2440, 2019
2802019
Deubiquitinase-targeting chimeras for targeted protein stabilization
NJ Henning, L Boike, JN Spradlin, CC Ward, G Liu, E Zhang, BP Belcher, ...
Nature chemical biology 18 (4), 412-421, 2022
2212022
Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue
J Ma, CC Ward, I Jungreis, SA Slavoff, AG Schwaid, J Neveu, BA Budnik, ...
Journal of proteome research 13 (3), 1757-1765, 2014
1962014
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
CYS Chung, HR Shin, CA Berdan, B Ford, CC Ward, JA Olzmann, ...
Nature chemical biology 15 (8), 776-785, 2019
1572019
NHS-esters as versatile reactivity-based probes for mapping proteome-wide ligandable hotspots
CC Ward, JI Kleinman, DK Nomura
ACS chemical biology 12 (6), 1478-1483, 2017
1452017
Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots
AM Roberts, CC Ward, DK Nomura
Current opinion in biotechnology 43, 25-33, 2017
1322017
Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products
EA Grossman, CC Ward, JN Spradlin, LA Bateman, TR Huffman, ...
Cell chemical biology 24 (11), 1368-1376. e4, 2017
1232017
Ligandability of E3 ligases for targeted protein degradation applications
BP Belcher, CC Ward, DK Nomura
Biochemistry 62 (3), 588-600, 2021
862021
Improving prime editing with an endogenous small RNA-binding protein
J Yan, P Oyler-Castrillo, P Ravisankar, CC Ward, S Levesque, Y Jing, ...
Nature 628 (8008), 639-647, 2024
582024
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT–liver communication
CH Sponton, T Hosono, J Taura, MP Jedrychowski, T Yoneshiro, Q Wang, ...
EMBO reports 21 (9), e49828, 2020
392020
Base-editing mutagenesis maps alleles to tune human T cell functions
R Schmidt, CC Ward, R Dajani, Z Armour-Garb, M Ota, V Allain, ...
Nature 625 (7996), 805-812, 2024
342024
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism
VN Pham, KJ Bruemmer, JDW Toh, EJ Ge, L Tenney, CC Ward, ...
Science 382 (6670), eabp9201, 2023
292023
Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2
SB Biering, E Van Dis, E Wehri, LH Yamashiro, X Nguyenla, ...
ACS infectious diseases 7 (8), 2337-2351, 2021
292021
Discovery of potent pyrazoline‐based covalent SARS‐CoV‐2 main protease inhibitors
P Moon, CM Zammit, Q Shao, D Dovala, L Boike, NJ Henning, M Knapp, ...
ChemBioChem 24 (11), e202300116, 2023
142023
Methods and compounds for targeted autophagy
DK Nomura, R Zoncu, C Ward, SK Fung, CK Varma, B Fontaine
US Patent 11,666,661, 2023
12023
Covalent targeting of E3 ligases
J Spradlin, CC Ward, DK Nomura, M Schirle, JA Tallarico, J McKenna, ...
US Patent 12,161,648, 2024
2024
Cellular behavior analysis from live-cell imaging of TCR T cell–cancer cell interactions
A Verma, C Yu, S Bachl, I Lopez, M Schwartz, E Moen, N Kale, C Ching, ...
bioRxiv, 2024.11. 19.624390, 2024
2024
Deubiquitinase-targeting chimeras and related methods
L Boike, DL Dovala, NJ Henning, MJ Hesse, G Liu, JM McKenna, ...
US Patent App. 18/288,550, 2024
2024
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