Следене
Iván Parra Izquierdo
Iván Parra Izquierdo
Senior Scientist at Boehringer Ingelheim
Потвърден имейл адрес: boehringer-ingelheim.com
Заглавие
Позовавания
Позовавания
Година
Toll-like receptors, inflammation, and calcific aortic valve disease
C García-Rodríguez, I Parra-Izquierdo, I Castaños-Mollor, J López, ...
Frontiers in physiology 9, 201, 2018
742018
Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs
Ö Babur, AR Melrose, JM Cunliffe, J Klimek, J Pang, ALI Sepp, ...
Blood, The Journal of the American Society of Hematology 136 (20), 2346-2358, 2020
702020
Lipopolysaccharide and interferon-γ team up to activate HIF-1α via STAT1 in normoxia and exhibit sex differences in human aortic valve interstitial cells
I Parra-Izquierdo, I Castaños-Mollor, J López, C Gómez, JA San Román, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1865 (9 …, 2019
662019
Calcification induced by type I interferon in human aortic valve interstitial cells is larger in males and blunted by a janus kinase inhibitor
I Parra-Izquierdo, I Castaños-Mollor, J López, C Gómez, JA San Román, ...
Arteriosclerosis, Thrombosis, and Vascular Biology 38 (9), 2148-2159, 2018
562018
The toll-like receptor 2 ligand Pam2CSK4 activates platelet nuclear factor-κB and Bruton’s tyrosine kinase signaling to promote platelet-endothelial cell interactions
I Parra-Izquierdo, HHS Lakshmanan, AR Melrose, J Pang, TJ Zheng, ...
Frontiers in Immunology 12, 729951, 2021
232021
Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function
I Parra-Izquierdo, AR Melrose, J Pang, HHS Lakshmanan, SE Reitsma, ...
Platelets 33 (3), 404-415, 2022
192022
Perspectives on platelet heterogeneity and host immune response in coronavirus disease 2019 (COVID-19)
I Parra-Izquierdo, JE Aslan
Seminars in thrombosis and hemostasis 46 (07), 826-830, 2020
182020
CRISPR-edited megakaryocytes for rapid screening of platelet gene functions
E Montenont, S Bhatlekar, S Jacob, Y Kosaka, BK Manne, O Lee, ...
Blood Advances 5 (9), 2362-2374, 2021
172021
Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease
ATP Ngo, I Parra-Izquierdo, JE Aslan, OJT McCarty
Small GTPases 12 (5-6), 440-457, 2021
142021
Interferons are pro-inflammatory cytokines in sheared-stressed human aortic valve endothelial cells
I Parra-Izquierdo, T Sánchez-Bayuela, J López, C Gómez, ...
International journal of molecular sciences 22 (19), 10605, 2021
142021
Chronic edible dosing of Δ9-tetrahydrocannabinol (THC) in nonhuman primates reduces systemic platelet activity and function
SE Reitsma, HHS Lakshmanan, J Johnson, J Pang, I Parra-Izquierdo, ...
American Journal of Physiology-Cell Physiology 322 (3), C370-C381, 2022
122022
Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity
TJ Zheng, TCL Kohs, PA Mueller, J Pang, SE Reitsma, I Parra-Izquierdo, ...
Blood Advances 7 (8), 1366-1378, 2023
112023
Thrombin generation and activity in multiple sclerosis
KR Jordan, I Parra-Izquierdo, A Gruber, JJ Shatzel, P Pham, LS Sherman, ...
Metabolic brain disease 36, 407-420, 2021
112021
Platelets and tyrosine kinase inhibitors: clinical features, mechanisms of action, and effects on physiology
TJ Zheng, I Parra-Izquierdo, SE Reitsma, MC Heinrich, MK Larson, ...
American Journal of Physiology-Cell Physiology 323 (4), C1231-C1250, 2022
102022
Clinically used JAK inhibitor blunts dsRNA‐induced inflammation and calcification in aortic valve interstitial cells
I Parra‐Izquierdo, T Sánchez‐Bayuela, I Castaños‐Mollor, J López, ...
The FEBS Journal 288 (22), 6528-6542, 2021
102021
Platelet miR-223 delivery rescues vascular cells in Kawasaki disease
I Parra-Izquierdo, OJT McCarty, JE Aslan
Circulation research 127 (7), 874-876, 2020
102020
Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia
TCL Kohs, HH Vu, KR Jordan, I Parra-Izquierdo, MT Hinds, JJ Shatzel, ...
Research and Practice in Thrombosis and Haemostasis 8 (1), 102276, 2024
62024
Platelets get gutted by PAG
I Parra-Izquierdo, R Bradley, JE Aslan
Platelets 31 (5), 618-620, 2020
62020
Pharmacological effects of small molecule BCR-ABL tyrosine kinase inhibitors on platelet function
Y Zhang, CJ Yang, AR Melrose, J Pang, K Schofield, SD Song, ...
The Journal of pharmacology and experimental therapeutics 392 (1), 100020, 2025
22025
PB0705 Pharmacological Inhibition of Coagulation Factor XI Reduces Thromboinflammation in a Nonhuman Primate Model of Early Atherosclerosis
T Kohs, I Parra-Izquierdo, H Vu, K Jordan, M Hinds, J Shatzel, P Kievit, ...
Research and Practice in Thrombosis and Haemostasis 7, 2023
2023
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