Следене
Hristo L. Svilenov
Hristo L. Svilenov
Потвърден имейл адрес: tum.de
Заглавие
Позовавания
Позовавания
Година
Solid lipid nanoparticles – A promising drug delivery system
H Svilenov, C Tzachev
Nanomedicine 8, 187-237, 2014
862014
Application of interpretable artificial neural networks to early monoclonal antibodies development
L Gentiluomo, D Roessner, D Augustijn, H Svilenov, A Kulakova, ...
European Journal of Pharmaceutics and Biopharmaceutics 141, 81-89, 2019
632019
Isothermal chemical denaturation as a complementary tool to overcome limitations of thermal differential scanning fluorimetry in predicting physical stability of protein …
H Svilenov, U Markoja, G Winter
European Journal of Pharmaceutics and Biopharmaceutics 125, 106-113, 2018
602018
Advancing therapeutic protein discovery and development through comprehensive computational and biophysical characterization
L Gentiluomo, HL Svilenov, D Augustijn, I El Bialy, ML Greco, A Kulakova, ...
Molecular Pharmaceutics 17 (2), 426-440, 2020
502020
The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage
H Svilenov, G Winter
European Journal of Pharmaceutics and Biopharmaceutics 137, 131-139, 2019
382019
Orthogonal Techniques to Study the Effect of pH, Sucrose, and Arginine Salts on Monoclonal Antibody Physical Stability and Aggregation During Long-term Storage
HL Svilenov, A Kulakova, M Zalar, AP Golovanov, P Harris, G Winter
Journal of pharmaceutical sciences 109 (1), 584-594, 2020
342020
A new approach to study the physical stability of monoclonal antibody formulations - dilution from a denaturant
H Svilenov, L Gentiluomo, W Friess, D Roessner, G Winter
Journal of pharmaceutical sciences 107 (12), 3007-3013, 2018
282018
Binding of excipients is a poor predictor for aggregation kinetics of biopharmaceutical proteins
M Zalar, HL Svilenov, AP Golovanov
European Journal of Pharmaceutics and Biopharmaceutics 151, 127-136, 2020
272020
Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties
HL Svilenov, P Arosio, T Menzen, P Tessier, P Sormanni
MAbs 15 (1), 2164459, 2023
252023
Modulated scanning fluorimetry can quickly assess thermal protein unfolding reversibility in microvolume samples
HL Svilenov, T Menzen, K Richter, G Winter
Molecular Pharmaceutics 17 (7), 2638–2647, 2020
242020
Antibodies gone bad–the molecular mechanism of light chain amyloidosis
RM Absmeier, GJ Rottenaicher, HL Svilenov, P Kazman, J Buchner
The FEBS Journal 290 (6), 1398-1419, 2023
212023
Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein
HL Svilenov, J Sacherl, A Reiter, LS Wolff, CC Cheng, M Stern, V Grass, ...
Antiviral Research 196, 105197, 2021
192021
Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody design
HL Svilenov, J Sacherl, U Protzer, M Zacharias, J Buchner
Nature Communications 12 (1), 6737, 2021
182021
Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations: Is there a correlation?
H Svilenov, G Winter
International Journal of Pharmaceutics 562, 42-50, 2019
182019
Formulations that suppress aggregation during long-term storage of a bispecific antibody are characterized by high refoldability and colloidal stability
HL Svilenov, G Winter
Journal of Pharmaceutical Sciences 109 (6), 2048-2058, 2020
172020
Structure-based discovery of a new protein-aggregation breaking excipient
A Tosstorff, H Svilenov, GHJ Peters, P Harris, G Winter
European Journal of Pharmaceutics and Biopharmaceutics 144, 207-216, 2019
152019
Combining Unfolding Reversibility Studies and Molecular Dynamics Simulations to Select Aggregation-Resistant Antibodies
C Berner, T Menzen, G Winter, HL Svilenov
Molecular Pharmaceutics 18 (6), 2242–2253, 2021
142021
Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants
HL Svilenov, R Bester, J Sacherl, R Absmeier, C Peters, U Protzer, ...
Communications Biology 5 (1), 1237, 2022
132022
Overcoming challenges in co-formulation of proteins with contradicting stability profiles-EPO plus G-CSF
D Krieg, H Svilenov, JH Gitter, G Winter
European Journal of Pharmaceutical Sciences 141, 105073, 2020
112020
Efficient inhibition of SARS-CoV-2 strains by a novel ACE2-IgG4-Fc fusion protein with a stabilized hinge region
HL Svilenov, J Sacherl, A Reiter, L Wolff, CC Chen, M Stern, FP Wachs, ...
BioRxiv, 2020.12. 06.413443, 2020
82020
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