| Base excision repair of oxidative DNA damage: from mechanism to disease AM Whitaker, MA Schaich, MS Smith, TS Flynn, BD Freudenthal Frontiers in bioscience (Landmark edition) 22, 1493, 2017 | 243 | 2017 |
| Observing a DNA polymerase choose right from wrong BD Freudenthal, WA Beard, DD Shock, SH Wilson Cell 154 (1), 157-168, 2013 | 234 | 2013 |
| Oxidative guanine base damage regulates human telomerase activity E Fouquerel, J Lormand, A Bose, HT Lee, GS Kim, J Li, RW Sobol, ... Nature structural & molecular biology 23 (12), 1092-1100, 2016 | 183 | 2016 |
| Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide BD Freudenthal, WA Beard, L Perera, DD Shock, T Kim, T Schlick, ... Nature 517 (7536), 635-639, 2015 | 167 | 2015 |
| Capturing snapshots of APE1 processing DNA damage BD Freudenthal, WA Beard, MJ Cuneo, NS Dyrkheeva, SH Wilson Nature structural & molecular biology 22 (11), 924-931, 2015 | 161 | 2015 |
| APE1: A skilled nucleic acid surgeon AM Whitaker, BD Freudenthal DNA repair 71, 93-100, 2018 | 149 | 2018 |
| Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange BD Freudenthal, L Gakhar, S Ramaswamy, MT Washington Nature structural & molecular biology 17 (4), 479-484, 2010 | 139 | 2010 |
| PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA LM Dieckman, BD Freudenthal, MT Washington The eukaryotic replisome: a guide to protein structure and function, 281-299, 2012 | 136 | 2012 |
| Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair R Prasad, JK Horton, PD Chastain, NR Gassman, BD Freudenthal, ... Nucleic acids research 42 (10), 6337-6351, 2014 | 108 | 2014 |
| Molecular snapshots of APE1 proofreading mismatches and removing DNA damage AM Whitaker, TS Flynn, BD Freudenthal Nature communications 9 (1), 399, 2018 | 104 | 2018 |
| Variations on a theme: eukaryotic Y-family DNA polymerases MT Washington, KD Carlson, BD Freudenthal, JM Pryor Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (5), 1113-1123, 2010 | 103 | 2010 |
| PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1 L Liu, M Kong, NR Gassman, BD Freudenthal, R Prasad, S Zhen, ... Nucleic acids research 45 (22), 12834-12847, 2017 | 96 | 2017 |
| Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-Jun N-terminal kinase JY Akakpo, A Ramachandran, L Duan, MA Schaich, MW Jaeschke, ... Toxicological Sciences 170 (1), 57-68, 2019 | 93 | 2019 |
| Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer BI Fedeles, BD Freudenthal, E Yau, V Singh, S Chang, D Li, JC Delaney, ... Proceedings of the National Academy of Sciences 112 (33), E4571-E4580, 2015 | 89 | 2015 |
| Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA SE Tsutakawa, AW Van Wynsberghe, BD Freudenthal, CP Weinacht, ... Proceedings of the National Academy of Sciences 108 (43), 17672-17677, 2011 | 72 | 2011 |
| Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops J Liu, C Ede, WD Wright, SK Gore, SS Jenkins, BD Freudenthal, ... Elife 6, e22195, 2017 | 68 | 2017 |
| Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance DR McNeill, AM Whitaker, WJ Stark, JL Illuzzi, PJ McKinnon, ... Mutagenesis 35 (1), 27-38, 2020 | 60 | 2020 |
| Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse L Perera, BD Freudenthal, WA Beard, DD Shock, LG Pedersen, ... Proceedings of the National Academy of Sciences 112 (38), E5228-E5236, 2015 | 57 | 2015 |
| Structures of dNTP intermediate states during DNA polymerase active site assembly BD Freudenthal, WA Beard, SH Wilson Structure 20 (11), 1829-1837, 2012 | 52 | 2012 |
| Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs SL Sanford, GA Welfer, BD Freudenthal, PL Opresko Nature Communications 11 (1), 5288, 2020 | 49 | 2020 |
