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Robert Lochhead, PhD
Robert Lochhead, PhD
Associate Professor, Medical College of Wisconsin Department of Microbiology and Immunology
Correu electrònic verificat a mcw.edu
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Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis
BL Jutras, RB Lochhead, ZA Kloos, J Biboy, K Strle, CJ Booth, SK Govers, ...
Proceedings of the National Academy of Sciences 116 (27), 13498-13507, 2019
1642019
Lyme arthritis: linking infection, inflammation and autoimmunity
RB Lochhead, K Strle, SL Arvikar, JJ Weis, AC Steere
Nature Reviews Rheumatology 17 (8), 449-461, 2021
1092021
Quorum sensing primes the oxidative stress response in the insect endosymbiont, Sodalis glossinidius
MH Pontes, M Babst, R Lochhead, K Oakeson, K Smith, C Dale
PloS one 3 (10), e3541, 2008
572008
MicroRNA-146a Provides Feedback Regulation of Lyme Arthritis but Not Carditis during Infection with Borrelia burgdorferi
RB Lochhead, Y Ma, JF Zachary, D Baltimore, JL Zhao, JH Weis, ...
PLoS pathogens 10 (6), e1004212, 2014
512014
Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected …
RB Lochhead, FL Sonderegger, Y Ma, JE Brewster, D Cornwall, ...
The Journal of Immunology 189 (5), 2488-2501, 2012
482012
Interferon‐gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast‐like synoviocytes into immune effector cells
RB Lochhead, D Ordoñez, SL Arvikar, JM Aversa, LS Oh, B Heyworth, ...
Cellular microbiology 21 (2), e12992, 2019
472019
Robust interferon signature and suppressed tissue repair gene expression in synovial tissue from patients with postinfectious, Borrelia burgdorferi‐induced Lyme …
RB Lochhead, SL Arvikar, JM Aversa, RI Sadreyev, K Strle, AC Steere
Cellular microbiology 21 (2), e12954, 2019
472019
MicroRNA expression shows inflammatory dysregulation and tumor‐like proliferative responses in joints of patients with postinfectious Lyme arthritis
RB Lochhead, K Strle, ND Kim, MJ Kohler, SL Arvikar, JM Aversa, ...
Arthritis & Rheumatology 69 (5), 1100-1110, 2017
442017
Borrelia burgdorferi Arthritis–Associated Locus Bbaa1 Regulates Lyme Arthritis and K/B× N Serum Transfer Arthritis through Intrinsic Control of Type I IFN Production
Y Ma, KKC Bramwell, RB Lochhead, JK Paquette, JF Zachary, JH Weis, ...
The Journal of Immunology 193 (12), 6050-6060, 2014
322014
Antagonistic interplay between microRNA-155 and IL-10 during Lyme carditis and arthritis
RB Lochhead, JF Zachary, L Dalla Rosa, Y Ma, JH Weis, RM O’Connell, ...
PLoS One 10 (8), e0135142, 2015
312015
Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis
K Kanjana, K Strle, RB Lochhead, A Pianta, LM Mateyka, Q Wang, ...
The Journal of Clinical Investigation 133 (17), 2023
192023
Correlation of Lyme disease–associated IgG4 autoantibodies with synovial pathology in antibiotic‐refractory Lyme arthritis
KB Sulka, K Strle, JT Crowley, RB Lochhead, R Anthony, AC Steere
Arthritis & Rheumatology 70 (11), 1835-1846, 2018
192018
Report of the pathogenesis and pathophysiology of Lyme disease subcommittee of the HHS Tick Borne Disease Working Group
ST Donta, LJ States, WA Adams, T Bankhead, N Baumgarth, ME Embers, ...
Frontiers in Medicine 8, 643235, 2021
122021
Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation
MN Holub, A Wahhab, JR Rouse, R Danner, LG Hackner, CB Duris, ...
Arthritis Research & Therapy 26 (1), 77, 2024
102024
Cell‐Mediated Cytotoxicity in Lyme Arthritis
D Ordóñez, RB Lochhead, K Strle, A Pianta, S Arvikar, I Van Rhijn, ...
Arthritis & Rheumatology 75 (5), 782-793, 2023
62023
HLA‐DR–Expressing Fibroblast‐Like Synoviocytes Are Inducible Antigen Presenting Cells That Present Autoantigens in Lyme Arthritis
JR Rouse, R Danner, A Wahhab, M Pereckas, C Nguyen, ME McClune, ...
ACR open rheumatology 6 (10), 678-689, 2024
32024
Immune fibroblasts are unconventional antigen presenting cells and nonprofessional phagocytes in Lyme arthritis
RB Lochhead, R Danner, A Wahhab, J Rouse
The Journal of Immunology 204 (1_Supplement), 148.29-148.29, 2020
22020
Extracellular micrornas in synovial fluid reveal a marked proliferative signature in patients with antibiotic-refractory lyme arthritis
RB Lochhead, ND Kim, S Arvikar, K Strle, AC Steere
ARTHRITIS & RHEUMATOLOGY 67, 2015
22015
Identification of Major Histocompatibility Complex Class II Epitopes From Lyme Autoantigen Apolipoprotein B-100 and Borrelia burgdorferi Mcp4 in Murine Lyme …
R Danner, LM Prochniak, M Pereckas, JR Rouse, A Wahhab, LG Hackner, ...
The Journal of Infectious Diseases 230 (Supplement_1), S27-S39, 2024
12024
Human leukocyte antigen HLA-DR-expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis
JR Rouse, R Danner, A Wahhab, M Pereckas, ME McClune, AC Steere, ...
bioRxiv, 2023
12023
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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