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Osha Roopnarine PhD
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Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin
JA Rohde, O Roopnarine, DD Thomas, JM Muretta
Proceedings of the National Academy of Sciences 115 (32), E7486-E7494, 2018
1542018
The mechanism of force generation in myosin: a disorder-to-order transition, coupled to internal structural changes
DD Thomas, S Ramachandran, O Roopnarine, DW Hayden, EM Ostap
Biophysical journal 68 (4 Suppl), 135S, 1995
1151995
Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy
O Roopnarine, LA Leinwand
Biophysical journal 75 (6), 3023-3030, 1998
741998
Orientation of intermediate nucleotide states of indane dione spin-labeled myosin heads in muscle fibers
O Roopnarine, DD Thomas
Biophysical journal 70 (6), 2795-2806, 1996
601996
Microsecond rotational dynamics of spin-labeled myosin regulatory light chain induced by relaxation and contraction of scallop muscle
O Roopnarine, AG Szent-Györgyi, DD Thomas
Biochemistry 37 (41), 14428-14436, 1998
441998
Context specific misreading of phenylalanine codons
J Precup, AK Ulrich, O Roopnarine, J Parker
Molecular and General Genetics MGG 218, 397-401, 1989
431989
Changes in actin and myosin structural dynamics due to their weak and strong interactions
DD Thomas, E Prochniewicz, O Roopnarine
Molecular Interactions of Actin: Actin-Myosin Interaction and Actin-Based …, 2002
382002
Mechanical defects of muscle fibers with myosin light chain mutants that cause cardiomyopathy
O Roopnarine
Biophysical journal 84 (4), 2440-2449, 2003
312003
Orientational dynamics of indane dione spin-labeled myosin heads in relaxed and contracting skeletal muscle fibers
O Roopnarine, DD Thomas
Biophysical journal 68 (4), 1461-1471, 1995
301995
Saturation transfer electron parametric resonance of an indane-dione spin-label. Calibration with hemoglobin and application to myosin rotational dynamics
O Roopnarine, K Hideg, DD Thomas
Biophysical journal 64 (6), 1896-1907, 1993
261993
A cardiomyopathy mutation in the myosin essential light chain alters actomyosin structure
P Guhathakurta, E Prochniewicz, O Roopnarine, JA Rohde, DD Thomas
Biophysical journal 113 (1), 91-100, 2017
232017
A spin label that binds to myosin heads in muscle fibers with its principal axis parallel to the fiber axis
O Roopnarine, DD Thomas
Biophysical journal 67 (4), 1634-1645, 1994
221994
A large-scale high-throughput screen for modulators of SERCA activity
PA Bidwell, SL Yuen, J Li, K Berg, RT Rebbeck, CC Aldrich, ...
Biomolecules 12 (12), 1789, 2022
172022
Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators
O Roopnarine, SL Yuen, AR Thompson, LN Roelike, RT Rebbeck, ...
Scientific reports 13 (1), 10673, 2023
92023
Interaction of DWORF with SERCA and PLB as determined by EPR spectroscopy
MD Rustad, O Roopnarine, RL Cornea, DD Thomas
Biochemical and biophysical research communications 645, 97-102, 2023
92023
Saturation transfer EPR spectroscopy with an indane dione spin label: calibration with hemoglobin and application to myosin rotational dynamics
O Roopnarine, K Hideg, DD Thomas
Biophys. J 64, 1986-1907, 1993
91993
Mechanistic analysis of actin-binding compounds that affect the kinetics of cardiac myosin–actin interaction
O Roopnarine, DD Thomas
Journal of Biological Chemistry 296, 2021
42021
An Overview of the Actin-Myosin Interaction
DD Thomas, O Roopnarine
Molecular Interactions of Actin: Actin-Myosin Interaction and Actin-Based …, 2002
42002
Saturation Transfer Electron Paramagnetic Resonance of Spin-Labeled Myosin Regulatory Light Chains in Contracting Muscle Fiber Bundles
O Roopnarine, AG Szent-Györgyi, DD Thomas
Biophysical Journal 68 (4 Suppl), 337s, 1995
41995
MUSCLE-CONTRACTION STUDIED WITH AN INDANE DIONE SPIN LABEL PROBING MYOSIN HEAVY AND LIGHT-CHAINS
O Roopnarine, K Hideg, AG SZENTGYORGYI, DD Thomas
BIOPHYSICAL JOURNAL 64 (2), A231-A231, 1993
31993
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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