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Jacob Kames
Jacob Kames
Correu electrònic verificat a fda.hhs.gov
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Codon and codon-pair usage tables (CoCoPUTs): facilitating genetic variation analyses and recombinant gene design
A Alexaki, J Kames, DD Holcomb, J Athey, LV Santana-Quintero, ...
Journal of molecular biology 431 (13), 2434-2441, 2019
1422019
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
A Alexaki, GK Hettiarachchi, JC Athey, UK Katneni, V Simhadri, ...
Scientific reports 9 (1), 15449, 2019
612019
Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
J Kames, DD Holcomb, O Kimchi, M DiCuccio, N Hamasaki-Katagiri, ...
Scientific reports 10 (1), 15643, 2020
582020
TissueCoCoPUTs: novel human tissue-specific codon and codon-pair usage tables based on differential tissue gene expression
J Kames, A Alexaki, DD Holcomb, LV Santana-Quintero, JC Athey, ...
Journal of molecular biology 432 (11), 3369-3378, 2020
352020
A Single Synonymous Variant (c.354G>A [p.P118P]) in ADAMTS13 Confers Enhanced Specific Activity
R Hunt, G Hettiarachchi, U Katneni, N Hernandez, D Holcomb, J Kames, ...
International journal of molecular sciences 20 (22), 5734, 2019
262019
Gene variants of coagulation related proteins that interact with SARS-CoV-2
D Holcomb, A Alexaki, N Hernandez, R Hunt, K Laurie, J Kames, ...
PLoS computational biology 17 (3), e1008805, 2021
232021
Translational and transcriptional responses in human primary hepatocytes under hypoxia
GK Hettiarachchi, UK Katneni, RC Hunt, JM Kames, JC Athey, H Bar, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology 316 (6 …, 2019
212019
Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage
D Meyer, J Kames, H Bar, AA Komar, A Alexaki, J Ibla, RC Hunt, ...
Genome Medicine 13, 1-18, 2021
132021
Structural, functional, and immunogenicity implications of F9 gene recoding
UK Katneni, A Alexaki, RC Hunt, N Hamasaki-Katagiri, GK Hettiarachchi, ...
Blood Advances 6 (13), 3932-3944, 2022
102022
New approaches to predict the effect of co-occurring variants on protein characteristics
D Holcomb, N Hamasaki-Katagiri, K Laurie, U Katneni, J Kames, ...
The American Journal of Human Genetics 108 (8), 1502-1511, 2021
82021
In silico evaluation of cyclophilin inhibitors as potential treatment for SARS-COV-2
K Laurie, D Holcomb, J Kames, AA Komar, M DiCuccio, JC Ibla, ...
Open Forum Infectious Diseases 8 (6), ofab189, 2021
72021
Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance
KI Jankowska, D Meyer, DD Holcomb, J Kames, N Hamasaki-Katagiri, ...
Blood advances 6 (18), 5364-5378, 2022
42022
Ribosome profiling of HEK293T cells overexpressing codon optimized coagulation factor IX
A Alexaki, J Kames, GK Hettiarachchi, JC Athey, UK Katneni, RC Hunt, ...
F1000Research 9, 2020
42020
Comprehensive NGS profiling to enable detection of ALK gene rearrangements and MET amplifications in non-small cell lung cancer
S Clavé, JB Jackson, M Salido, J Kames, KMR Gerding, EL Verner, ...
Frontiers in Oncology 13, 1225646, 2023
32023
Potential impact on coagulopathy of gene variants of coagulation related proteins that interact with SARS-CoV-2
D Holcomb, A Alexaki, N Hernandez, K Laurie, J Kames, ...
bioRxiv, 2020.09. 08.272328, 2020
32020
Protocol to identify host-viral protein interactions between coagulation-related proteins and their genetic variants with SARS-CoV-2 proteins
DD Holcomb, KI Jankowska, N Hernandez, K Laurie, J Kames, ...
STAR protocols 3 (3), 101648, 2022
12022
Complimentary use of DNA-and RNA-based NGS assays optimizes detection of clinically relevant translocations for comprehensive genomic profiling
R Ren, J Jackson, J Kames, D Riles, C Coldren, S Wheeler, P Chandra, ...
Cancer Research 83 (7_Supplement), 5452-5452, 2023
2023
SYNONYMOUS ADAMTS13 VARIANTS IMPACT MOLECULAR CHARACTERISTICS AND CONTRIBUTE TO VARIABILITY IN ACTIVE PROTEIN ABUNDANCE
KI Jankowska, D Meyer, DD Holcomb, J Kames, N Katagiri, ...
AMERICAN JOURNAL OF HEMATOLOGY 98, E49-E50, 2023
2023
Comprehensive NGS profiling to enable detection of ALK gene rearrangements and MET amplifications in non-small cell lung cancer
B Sun, E Arriola, S Clavé, JB Jackson, M Salido, J Kames, KMR Gerding, ...
2023
Ribosome profiling of HEK293T cells overexpressin g codon optimized coagulation factor IX [version 2; peer review
A Alexaki, J Kames, GK Hettiarachchi, JC Athey, UK Katneni, RC Hunt, ...
2020
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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