Mitochondrial DNA stress signalling protects the nuclear genome Z Wu, S Oeck, AP West, KC Mangalhara, AG Sainz, LE Newman, ... Nature metabolism 1 (12), 1209-1218, 2019 | 114 | 2019 |
Mitohormesis in mice via sustained basal activation of mitochondrial and antioxidant signaling CS Cox, SE McKay, MA Holmbeck, BE Christian, AC Scortea, AJ Tsay, ... Cell metabolism 28 (5), 776-786. e5, 2018 | 114 | 2018 |
Mitochondrial DNA release in innate immune signaling LE Newman, GS Shadel Annual review of biochemistry 92 (1), 299-332, 2023 | 95 | 2023 |
Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration LE Newman, GS Shadel The Journal of cell biology 217 (10), 3327, 2018 | 64 | 2018 |
The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels LE Newman, C Zhou, S Mudigonda, AL Mattheyses, E Paradies, ... PloS one 9 (6), e99270, 2014 | 48 | 2014 |
A trimer consisting of the tubulin-specific chaperone D (TBCD), regulatory GTPase ARL2, and β-tubulin is required for maintaining the microtubule network JW Francis, LE Newman, LA Cunningham, RA Kahn Journal of Biological Chemistry 292 (10), 4336-4349, 2017 | 46 | 2017 |
The polyadenosine RNA-binding protein, zinc finger Cys3His protein 14 (ZC3H14), regulates the pre-mRNA processing of a key ATP synthase subunit mRNA CP Wigington, KJ Morris, LE Newman, AH Corbett Journal of Biological Chemistry 291 (43), 22442-22459, 2016 | 34 | 2016 |
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal LE Newman, S Weiser Novak, GR Rojas, N Tadepalle, CR Schiavon, ... Nature cell biology 26 (2), 194-206, 2024 | 32 | 2024 |
Oligomerization of the Sec7 domain Arf guanine nucleotide exchange factor GBF1 is dispensable for Golgi localization and function but regulates degradation JM Bhatt, EG Viktorova, T Busby, P Wyrozumska, LE Newman, H Lin, ... American Journal of Physiology-Cell Physiology 310 (6), C456-C469, 2016 | 27 | 2016 |
ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2 CR Schiavon, RE Turn, LE Newman, RA Kahn Molecular biology of the cell 30 (10), 1198-1213, 2019 | 23 | 2019 |
The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space LE Newman, CR Schiavon, RE Turn, RA Kahn Cellular logistics 7 (3), e1340104, 2017 | 23 | 2017 |
Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions JW Francis, RE Turn, LE Newman, C Schiavon, RA Kahn Small GTPases 7 (4), 188-196, 2016 | 22 | 2016 |
The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors LE Newman, CR Schiavon, C Zhou, RA Kahn PloS one 12 (4), e0175164, 2017 | 21 | 2017 |
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT I Al Khatib, J Deng, Y Lei, S Torres-Odio, GR Rojas, LE Newman, ... Human Molecular Genetics 32 (15), 2422-2440, 2023 | 18 | 2023 |
Plasmids for variable expression of proteins targeted to the mitochondrial matrix or intermembrane space LE Newman, C Schiavon, RA Kahn Cellular logistics 6 (4), e1247939, 2016 | 18 | 2016 |
The biology of aging in a social world: insights from free-ranging rhesus macaques LE Newman, C Testard, AR DeCasien, KL Chiou, MM Watowich, ... Neuroscience & Biobehavioral Reviews 154, 105424, 2023 | 13 | 2023 |
Intrasexual male competition LE Newman, JP Higham Encyclopedia of Evolutionary Psychological Science, 4204-4209, 2021 | 4 | 2021 |
Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA LE Newman, N Tadepalle, SW Novak, CR Schiavon, GR Rojas, ... bioRxiv, 2022.10. 12.511955, 2022 | 3 | 2022 |
Social Status is Associated with Impaired Anti-Inflammatory Response in Free-Ranging Male Rhesus Macaques MR Sanchez Rosado, L Newman, M Watowich, M Pavez-Fox, JND Valle, ... The Journal of Immunology 210 (Supplement_1), 248.13-248.13, 2023 | 1 | 2023 |
Conserved and distinct signatures of transcriptional aging across tissues in rhesus macaques LE Newman American Journal of Biological Anthropology 180 (S75), 2023 | | 2023 |