| The path to the clinic: a comprehensive review on direct KRASG12C inhibitors AK Kwan, GA Piazza, AB Keeton, CA Leite Journal of Experimental & Clinical Cancer Research 41 (1), 27, 2022 | 146 | 2022 |
| Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferation W Lu, HN Tinsley, A Keeton, Z Qu, GA Piazza, Y Li European journal of pharmacology 602 (1), 8-14, 2009 | 146 | 2009 |
| Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling N Li, Y Xi, HN Tinsley, E Gurpinar, BD Gary, B Zhu, Y Li, X Chen, ... Molecular cancer therapeutics 12 (9), 1848-1859, 2013 | 141 | 2013 |
| Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of … HN Tinsley, BD Gary, AB Keeton, W Zhang, AH Abadi, RC Reynolds, ... Molecular cancer therapeutics 8 (12), 3331-3340, 2009 | 119 | 2009 |
| A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity GA Piazza, AB Keeton, HN Tinsley, BD Gary, JD Whitt, B Mathew, ... Cancer Prevention Research 2 (6), 572-580, 2009 | 112 | 2009 |
| Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin–mediated transcription in human breast tumor cells HN Tinsley, BD Gary, AB Keeton, W Lu, Y Li, GA Piazza Cancer prevention research 4 (8), 1275-1284, 2011 | 111 | 2011 |
| Colon tumor cell growth–inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition HN Tinsley, BD Gary, J Thaiparambil, N Li, W Lu, Y Li, YY Maxuitenko, ... Cancer Prevention Research 3 (10), 1303-1313, 2010 | 95 | 2010 |
| Insulin-regulated expression of Egr-1 and Krox20: dependence on ERK1/2 and interaction with p38 and PI3-kinase pathways AB Keeton, KD Bortoff, WL Bennett, JL Franklin, DY Venable, JL Messina Endocrinology 144 (12), 5402-5410, 2003 | 94 | 2003 |
| The RAS–effector interaction as a drug target AB Keeton, EA Salter, GA Piazza Cancer research 77 (2), 221-226, 2017 | 86 | 2017 |
| A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity JD Whitt, N Li, HN Tinsley, X Chen, W Zhang, Y Li, BD Gary, AB Keeton, ... Cancer prevention research 5 (6), 822-833, 2012 | 83 | 2012 |
| NSAIDs: old drugs reveal new anticancer targets GA Piazza, AB Keeton, HN Tinsley, JD Whitt, BD Gary, B Mathew, R Singh, ... Pharmaceuticals 3 (5), 1652-1667, 2010 | 83 | 2010 |
| Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity N Li, K Lee, Y Xi, B Zhu, BD Gary, V Ramírez-Alcántara, E Gurpinar, ... Oncogene 34 (12), 1499-1509, 2015 | 73 | 2015 |
| Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity FM Awadallah, GA Piazza, BD Gary, AB Keeton, JC Canzoneri European journal of medicinal chemistry 70, 273-279, 2013 | 67 | 2013 |
| Insulin enhances growth hormone induction of the MEK/ERK signaling pathway J Xu, AB Keeton, JL Franklin, X Li, DY Venable, SJ Frank, JL Messina Journal of Biological Chemistry 281 (2), 982-992, 2006 | 66 | 2006 |
| Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents WM Eldehna, RI Al-Wabli, MS Almutairi, AB Keeton, GA Piazza, ... Journal of enzyme inhibition and medicinal chemistry 33 (1), 867-878, 2018 | 61 | 2018 |
| β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG K Lee, AS Lindsey, N Li, B Gary, J Andrews, AB Keeton, GA Piazza Oncotarget 7 (5), 5353, 2015 | 60 | 2015 |
| PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity GA Piazza, A Ward, X Chen, Y Maxuitenko, A Coley, NS Aboelella, ... Drug discovery today 25 (8), 1521-1527, 2020 | 58 | 2020 |
| Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling HA Abdel-Aziz, WM Eldehna, AB Keeton, GA Piazza, AA Kadi, MW Attwa, ... Drug Design, Development and Therapy, 2333-2346, 2017 | 57 | 2017 |
| Insulin signal transduction pathways and insulin-induced gene expression AB Keeton, MO Amsler, DY Venable, JL Messina Journal of Biological Chemistry 277 (50), 48565-48573, 2002 | 54 | 2002 |
| A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy E Gurpinar, WE Grizzle, JJ Shacka, BJ Mader, N Li, NA Piazza, S Russo, ... Molecular cancer therapeutics 12 (5), 663-674, 2013 | 53 | 2013 |
Gary Anthony PiazzaEndowed Professor and Department HeadCorreu electrònic verificat a auburn.edu