Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia JB Davis, J Gray, MJ Gunthorpe, JP Hatcher, PT Davey, P Overend, ... Nature 405 (6783), 183-187, 2000 | 2150 | 2000 |
TRPV3 is a temperature-sensitive vanilloid receptor-like protein GD Smith, MJ Gunthorpe, RE Kelsell, PD Hayes, P Reilly, P Facer, ... Nature 418 (6894), 186-190, 2002 | 1035 | 2002 |
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1) D Smart, MJ Gunthorpe, JC Jerman, S Nasir, J Gray, AI Muir, ... British journal of pharmacology 129 (2), 227-230, 2000 | 943 | 2000 |
The diversity in the vanilloid (TRPV) receptor family of ion channels MJ Gunthorpe, CD Benham, A Randall, JB Davis Trends in pharmacological sciences 23 (4), 183-191, 2002 | 631 | 2002 |
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1 M Trevisani, D Smart, MJ Gunthorpe, M Tognetto, M Barbieri, B Campi, ... Nature neuroscience 5 (6), 546-551, 2002 | 530 | 2002 |
Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential L Mony, JNC Kew, MJ Gunthorpe, P Paoletti British journal of pharmacology 157 (8), 1301-1317, 2009 | 506 | 2009 |
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1) FN McNamara, A Randall, MJ Gunthorpe British journal of pharmacology 144 (6), 781, 2005 | 442 | 2005 |
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1 P Hayes, HJ Meadows, MJ Gunthorpe, MH Harries, MD Duckworth, ... Pain 88 (2), 205-215, 2000 | 402 | 2000 |
The voltage-gated sodium channel Nav1. 9 is an effector of peripheral inflammatory pain hypersensitivity F Amaya, H Wang, M Costigan, AJ Allchorne, JP Hatcher, J Egerton, ... Journal of Neuroscience 26 (50), 12852-12860, 2006 | 393 | 2006 |
The mechanism of action of retigabine (ezogabine), a first‐in‐class K+ channel opener for the treatment of epilepsy MJ Gunthorpe, CH Large, R Sankar Epilepsia 53 (3), 412-424, 2012 | 365 | 2012 |
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist MJ Gunthorpe, HK Rami, JC Jerman, D Smart, CH Gill, EM Soffin, ... Neuropharmacology 46 (1), 133-149, 2004 | 330 | 2004 |
TRPV channels as temperature sensors CD Benham, MJ Gunthorpe, JB Davis Cell calcium 33 (5-6), 479-487, 2003 | 318 | 2003 |
Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway MJ Gunthorpe, BA Chizh Drug discovery today 14 (1-2), 56-67, 2009 | 270 | 2009 |
Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms A Szallasi, MJ Gunthorpe Current pharmaceutical design 14 (1), 32-41, 2008 | 263 | 2008 |
TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons U Anand, WR Otto, P Facer, N Zebda, I Selmer, MJ Gunthorpe, ... Neuroscience letters 438 (2), 221-227, 2008 | 206 | 2008 |
Conservation of functional and pharmacological properties in the distantly related temperature sensors TRPV1 and TRPM8 A Weil, SE Moore, NJ Waite, A Randall, MJ Gunthorpe Molecular pharmacology 68 (2), 518-527, 2005 | 198 | 2005 |
Conversion of the ion selectivity of the 5-HT3Areceptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily MJ Gunthorpe, SCR Lummis Journal of Biological Chemistry 276 (14), 10977-10983, 2001 | 177 | 2001 |
Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development HK Rami, M Thompson, G Stemp, S Fell, JC Jerman, AJ Stevens, D Smart, ... Bioorganic & medicinal chemistry letters 16 (12), 3287-3291, 2006 | 163 | 2006 |
Effects of pan-and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine M Peeters, MJ Gunthorpe, PJLM Strijbos, P Goldsmith, N Upton, ... Journal of Pharmacology and Experimental Therapeutics 321 (2), 564-572, 2007 | 159 | 2007 |
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease A Di Sabatino, L Rovedatti, R Kaur, JP Spencer, JT Brown, VD Morisset, ... The Journal of Immunology 183 (5), 3454-3462, 2009 | 130 | 2009 |