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Martin Gunthorpe
Martin Gunthorpe
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Correu electrònic verificat a alterionconsulting.com
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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
JB Davis, J Gray, MJ Gunthorpe, JP Hatcher, PT Davey, P Overend, ...
Nature 405 (6783), 183-187, 2000
21502000
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
GD Smith, MJ Gunthorpe, RE Kelsell, PD Hayes, P Reilly, P Facer, ...
Nature 418 (6894), 186-190, 2002
10352002
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
D Smart, MJ Gunthorpe, JC Jerman, S Nasir, J Gray, AI Muir, ...
British journal of pharmacology 129 (2), 227-230, 2000
9432000
The diversity in the vanilloid (TRPV) receptor family of ion channels
MJ Gunthorpe, CD Benham, A Randall, JB Davis
Trends in pharmacological sciences 23 (4), 183-191, 2002
6312002
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
M Trevisani, D Smart, MJ Gunthorpe, M Tognetto, M Barbieri, B Campi, ...
Nature neuroscience 5 (6), 546-551, 2002
5302002
Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential
L Mony, JNC Kew, MJ Gunthorpe, P Paoletti
British journal of pharmacology 157 (8), 1301-1317, 2009
5062009
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)
FN McNamara, A Randall, MJ Gunthorpe
British journal of pharmacology 144 (6), 781, 2005
4422005
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
P Hayes, HJ Meadows, MJ Gunthorpe, MH Harries, MD Duckworth, ...
Pain 88 (2), 205-215, 2000
4022000
The voltage-gated sodium channel Nav1. 9 is an effector of peripheral inflammatory pain hypersensitivity
F Amaya, H Wang, M Costigan, AJ Allchorne, JP Hatcher, J Egerton, ...
Journal of Neuroscience 26 (50), 12852-12860, 2006
3932006
The mechanism of action of retigabine (ezogabine), a first‐in‐class K+ channel opener for the treatment of epilepsy
MJ Gunthorpe, CH Large, R Sankar
Epilepsia 53 (3), 412-424, 2012
3652012
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist
MJ Gunthorpe, HK Rami, JC Jerman, D Smart, CH Gill, EM Soffin, ...
Neuropharmacology 46 (1), 133-149, 2004
3302004
TRPV channels as temperature sensors
CD Benham, MJ Gunthorpe, JB Davis
Cell calcium 33 (5-6), 479-487, 2003
3182003
Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway
MJ Gunthorpe, BA Chizh
Drug discovery today 14 (1-2), 56-67, 2009
2702009
Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms
A Szallasi, MJ Gunthorpe
Current pharmaceutical design 14 (1), 32-41, 2008
2632008
TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons
U Anand, WR Otto, P Facer, N Zebda, I Selmer, MJ Gunthorpe, ...
Neuroscience letters 438 (2), 221-227, 2008
2062008
Conservation of functional and pharmacological properties in the distantly related temperature sensors TRPV1 and TRPM8
A Weil, SE Moore, NJ Waite, A Randall, MJ Gunthorpe
Molecular pharmacology 68 (2), 518-527, 2005
1982005
Conversion of the ion selectivity of the 5-HT3Areceptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily
MJ Gunthorpe, SCR Lummis
Journal of Biological Chemistry 276 (14), 10977-10983, 2001
1772001
Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development
HK Rami, M Thompson, G Stemp, S Fell, JC Jerman, AJ Stevens, D Smart, ...
Bioorganic & medicinal chemistry letters 16 (12), 3287-3291, 2006
1632006
Effects of pan-and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine
M Peeters, MJ Gunthorpe, PJLM Strijbos, P Goldsmith, N Upton, ...
Journal of Pharmacology and Experimental Therapeutics 321 (2), 564-572, 2007
1592007
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease
A Di Sabatino, L Rovedatti, R Kaur, JP Spencer, JT Brown, VD Morisset, ...
The Journal of Immunology 183 (5), 3454-3462, 2009
1302009
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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