Inverse agonism at G protein-coupled receptors:(patho) physiological relevance and implications for drug discovery RAF De Ligt, AP Kourounakis, AP IJzerman British journal of pharmacology 130 (1), 1, 2000 | 252 | 2000 |
Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules AP Kourounakis, D Xanthopoulos, A Tzara Medicinal Research Reviews 40 (2), 709-752, 2020 | 234 | 2020 |
Investigation of the effect of chamazulene on lipid peroxidation and free radical processes. EA Rekka, AP Kourounakis, PN Kourounakis Research communications in molecular pathology and pharmacology 92 (3), 361-364, 1996 | 177 | 1996 |
Alkannin and Shikonin: effect on free radical processes and on inflammation‐a preliminary pharmacochemical investigation AP Kourounakis, AN Assimopoulou, VP Papageorgiou, A Gavalas, ... Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal …, 2002 | 159 | 2002 |
Antinociceptive properties of 1, 8-cineole and β-pinene, from the essential oil of Eucalyptus camaldulensis leaves, in rodents C Liapi, G Anifantis, I Chinou, AP Kourounakis, S Theodosopoulos, ... Planta medica 73 (12), 1247-1254, 2007 | 146 | 2007 |
Allosteric Modulation of the Adenosine A1 Receptor. Synthesis and Biological Evaluation of Novel 2-Amino-3-benzoylthiophenes as Allosteric Enhancers of … PAM van der Klein, AP Kourounakis, AP IJzerman Journal of medicinal chemistry 42 (18), 3629-3635, 1999 | 125 | 1999 |
Synthesis and pharmacological evaluation of novel derivatives of anti‐inflammatory drugs with increased antioxidant and anti‐inflammatory activities AP Kourounakis, D Galanakis, K Tsiakitzis, EA Rekka, PN Kourounakis Drug Development Research 47 (1), 9-16, 1999 | 116 | 1999 |
Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats AP Kourounakis, EA Rekka, PN Kourounakis Journal of pharmacy and pharmacology 49 (9), 938-942, 1997 | 101 | 1997 |
Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with … D Galanakis, AP Kourounakis, KC Tsiakitzis, C Doulgkeris, EA Rekka, ... Bioorganic & medicinal chemistry letters 14 (14), 3639-3643, 2004 | 100 | 2004 |
Morpholine as a scaffold in medicinal chemistry: an update on synthetic strategies A Tzara, D Xanthopoulos, AP Kourounakis ChemMedChem 15 (5), 392-403, 2020 | 82 | 2020 |
Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity E Rekka, M Chrysselis, I Siskou, A Kourounakis Chemical and pharmaceutical bulletin 50 (7), 904-907, 2002 | 81 | 2002 |
Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias M Koufaki, A Detsi, E Theodorou, C Kiziridi, T Calogeropoulou, ... Bioorganic & medicinal chemistry 12 (18), 4835-4841, 2004 | 80 | 2004 |
Anti-inflammatory properties of diclofenac transition metalloelement complexes M Konstandinidou, A Kourounakis, M Yiangou, L Hadjipetrou, ... Journal of inorganic biochemistry 70 (1), 63-69, 1998 | 80 | 1998 |
Novel benzoxazine and benzothiazine derivatives as multifunctional antihyperlipidemic agents AN Matralis, MG Katselou, A Nikitakis, AP Kourounakis Journal of medicinal chemistry 54 (15), 5583-5591, 2011 | 77 | 2011 |
Experimental hyperlipidemia and the effect of NSAIDs AP Kourounakis, P Victoratos, N Peroulis, N Stefanou, M Yiangou, ... Experimental and Molecular Pathology 73 (2), 135-138, 2002 | 77 | 2002 |
Reduction of gastrointestinal toxicity of NSAIDs via molecular modifications leading to antioxidant anti-inflammatory drugs PN Kourounakis, K Tsiakitzis, AP Kourounakis, D Galanakis Toxicology 144 (1-3), 205-210, 2000 | 77 | 2000 |
Anti-inflammatory and immunomodulating properties of grape melanin. Inhibitory effects on paw edema and adjuvant induced disease. N Avramidis, A Kourounakis, L Hadjipetrou, V Senchuk Arzneimittel-forschung 48 (7), 764-771, 1998 | 73 | 1998 |
5‘-N-Substituted Carboxamidoadenosines as Agonists for Adenosine Receptors M de Zwart, A Kourounakis, H Kooijman, AL Spek, R Link, ... Journal of medicinal chemistry 42 (8), 1384-1392, 1999 | 71 | 1999 |
Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias M Koufaki, T Calogeropoulou, A Detsi, A Roditis, AP Kourounakis, ... Journal of medicinal chemistry 44 (24), 4300-4303, 2001 | 65 | 2001 |
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: Exploiting phenothiazine’s strong antioxidant activity AN Matralis, AP Kourounakis Journal of medicinal chemistry 57 (6), 2568-2581, 2014 | 59 | 2014 |