| TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells D Bestle, MR Heindl, H Limburg, O Pilgram, H Moulton, DA Stein, ... Life science alliance 3 (9), 2020 | 887 | 2020 |
| Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium E Böttcher, T Matrosovich, M Beyerle, HD Klenk, W Garten, ... Journal of virology 80 (19), 9896-9898, 2006 | 628 | 2006 |
| Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors E Böttcher-Friebertshäuser, C Freuer, F Sielaff, S Schmidt, ... Journal of virology 84 (11), 5605-5614, 2010 | 260 | 2010 |
| Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium E Böttcher-Friebertshäuser, HD Klenk, W Garten Pathogens and disease 69 (2), 87-100, 2013 | 207 | 2013 |
| MSC based therapies—new perspectives for the injured lung J Behnke, S Kremer, T Shahzad, CM Chao, E Böttcher-Friebertshäuser, ... Journal of clinical medicine 9 (3), 682, 2020 | 175 | 2020 |
| TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes H Limburg, A Harbig, D Bestle, DA Stein, HM Moulton, J Jaeger, H Janga, ... Journal of virology 93 (21), 10.1128/jvi. 00649-19, 2019 | 172 | 2019 |
| TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice C Tarnow, G Engels, A Arendt, F Schwalm, H Sediri, A Preuss, PS Nelson, ... Journal of virology 88 (9), 4744-4751, 2014 | 168 | 2014 |
| The hemagglutinin: a determinant of pathogenicity E Böttcher-Friebertshäuser, W Garten, M Matrosovich, HD Klenk Influenza Pathogenesis and Control-Volume I, 3-34, 2014 | 160 | 2014 |
| Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses J Baron, C Tarnow, D Mayoli-Nüssle, E Schilling, D Meyer, M Hammami, ... Journal of virology 87 (3), 1811-1820, 2013 | 154 | 2013 |
| Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation D Meyer, F Sielaff, M Hammami, E Böttcher-Friebertshäuser, W Garten, ... Biochemical Journal 452 (2), 331-343, 2013 | 150 | 2013 |
| Activation of viruses by host proteases E Böttcher-Friebertshäuser, W Garten, HD Klenk Springer 963, 964, 2018 | 133* | 2018 |
| MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition E Böttcher, C Freuer, T Steinmetzer, HD Klenk, W Garten Vaccine 27 (45), 6324-6329, 2009 | 120 | 2009 |
| Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2 E Böttcher-Friebertshäuser, DA Stein, HD Klenk, W Garten Journal of virology 85 (4), 1554-1562, 2011 | 116 | 2011 |
| Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza … Y Okumura, E Takahashi, M Yano, M Ohuchi, T Daidoji, T Nakaya, ... Journal of virology 84 (10), 5089-5096, 2010 | 113 | 2010 |
| Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics W Garten, C Braden, A Arendt, C Peitsch, J Baron, Y Lu, K Pawletko, ... European journal of cell biology 94 (7-9), 375-383, 2015 | 105 | 2015 |
| Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia TV Kalymbetova, B Selvakumar, JA Rodríguez‐Castillo, M Gunjak, ... The Journal of pathology 245 (2), 153-159, 2018 | 76 | 2018 |
| Soluble polysialylated NCAM: a novel player of the innate immune system in the lung C Ulm, M Saffarzadeh, P Mahavadi, S Müller, G Prem, F Saboor, P Simon, ... Cellular and molecular life sciences 70, 3695-3708, 2013 | 66 | 2013 |
| Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections E Böttcher-Friebertshäuser, Y Lu, D Meyer, F Sielaff, T Steinmetzer, ... Vaccine 30 (51), 7374-7380, 2012 | 56 | 2012 |
| Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT F Sielaff, E Böttcher-Friebertshäuser, D Meyer, SM Saupe, IM Volk, ... Bioorganic & medicinal chemistry letters 21 (16), 4860-4864, 2011 | 54 | 2011 |
| The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes F Ferrara, E Molesti, E Böttcher-Friebertshäuser, G Cattoli, D Corti, ... Journal of molecular and genetic medicine: an international journal of …, 2013 | 53 | 2013 |
