Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing AV Anzalone*, XD Gao*, CJ Podracky*, AT Nelson, LW Koblan, ... Nature biotechnology 40 (5), 731-740, 2022 | 413 | 2022 |
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing Y Xu, XD Gao, JH Lee, H Huang, H Tan, J Ahn, LM Reinke, ME Peter, ... Genes & Development, 1191-1203, 2014 | 241 | 2014 |
CD44 splice isoform switching determines breast cancer stem cell state H Zhang, RL Brown, Y Wei, P Zhao, S Liu, X Liu, Y Deng, X Hu, J Zhang, ... Genes & Development 33 (3-4), 166-179, 2019 | 207 | 2019 |
NmeCas9 is an intrinsically high-fidelity genome-editing platform N Amrani*, XD Gao*, P Liu, A Edraki, A Mir, R Ibraheim, A Gupta, ... Genome Biology 19 (1), 214, 2018 | 143 | 2018 |
C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9–APEX2 XD Gao, LC Tu, A Mir, T Rodriguez, Y Ding, J Leszyk, J Dekker, ... Nature methods 15 (6), 433-436, 2018 | 142 | 2018 |
Phage-assisted evolution and protein engineering yield compact, efficient prime editors JL Doman*, S Pandey*, ME Neugebauer, M An, JR Davis, PB Randolph, ... Cell 186 (18), 3983-4002. e26, 2023 | 125 | 2023 |
Potent Cas9 inhibition in bacterial and human cells by AcrIIC4 and AcrIIC5 Anti-CRISPR proteins J Lee, A Mir, A Edraki, B Garcia, N Amrani, HE Lou, I Gainetdinov, ... MBio 9 (6), e02321-18, 2018 | 98 | 2018 |
Coregulation of alternative splicing by hnRNPM and ESRP1 during EMT SE Harvey, Y Xu, X Lin, XD Gao, Y Qiu, J Ahn, X Xiao, C Cheng Rna 24 (10), 1326-1338, 2018 | 73 | 2018 |
In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration EH Choi*, S Suh*, AT Foik, H Leinonen, GA Newby, XD Gao, S Banskota, ... Nature communications 13 (1), 1830, 2022 | 55 | 2022 |
Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector H Zhang, N Bamidele, P Liu, O Ojelabi, XD Gao, T Rodriguez, H Cheng, ... GEN biotechnology 1 (3), 285-299, 2022 | 40 | 2022 |
Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing S Pandey*, XD Gao*, NA Krasnow, A McElroy, YA Tao, JE Duby, ... Nature Biomedical Engineering, 1-18, 2024 | 32 | 2024 |
Adapting dCas9-APEX2 for subnuclear proteomic profiling XD Gao, TC Rodríguez, EJ Sontheimer Methods in Enzymology 616, 365-383, 2019 | 9 | 2019 |
Prime editing: current advances and therapeutic opportunities in human diseases Y Fu*, X He*, XD Gao*, F Li, S Ge, Z Yang, X Fan Science Bulletin, 2023 | 8 | 2023 |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence David R Liu, Andrew Vito Anzalone, Jonathan Ma Levy, Xin Gao, Christopher J ... US Patent US11912985B2, 2023 | 8* | 2023 |
Twin prime editing mediated exon skipping/reinsertion for restored collagen VII expression in recessive dystrophic epidermolysis bullosa BJ Steinbeck*, XD Gao*, AN McElroy, S Pandey, JL Doman, MJ Riddle, ... Journal of Investigative Dermatology, 2024 | 4 | 2024 |
Methods and compositions for modulating cellular factors to increase prime editing efficiencies DR Liu, PJ Chen, X Gao WO Patent App. WO2024138087A2, 2024 | | 2024 |
Prime editing DR Liu, AV Anzalone, JM Levy, X Gao, CJ Podracky nature biotechnology 42 (570), 570, 2024 | | 2024 |
Crispr base editor Yan Zhang, David R. Liu, Xin GAO, Kevin T. ZHAO, Zhonggang HOU WO Patent App. WO2024044329A1, 2024 | | 2024 |
Methods and compositions for editing a genome with prime editing and a recombinase David R. Liu, Andrew Vito Anzalone, Jonathan Ma Levy, Xin Gao, Christopher J ... WO Patent App. WO2023076898A1, 2023 | | 2023 |
Programmable dna base editing by nme2cas9-deaminase fusion proteins Erik J Sontheimer, Xin Gao, Aamir Mir, Alireza Edraki, Scot A Wolfe ... US Patent App. 17/285,440, 2022 | | 2022 |