| Hypoxia-inducible factors and the response to hypoxic stress AJ Majmundar, WJ Wong, MC Simon Molecular cell 40 (2), 294-309, 2010 | 2780 | 2010 |
| Mitochondrial reactive oxygen species trigger hypoxia-induced transcription NS Chandel, E Maltepe, E Goldwasser, CE Mathieu, MC Simon, ... Proceedings of the National Academy of Sciences 95 (20), 11715-11720, 1998 | 2441 | 1998 |
| Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase MA Selak, SM Armour, ED MacKenzie, H Boulahbel, DG Watson, ... Cancer cell 7 (1), 77-85, 2005 | 2421 | 2005 |
| HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression B Keith, RS Johnson, MC Simon Nature Reviews Cancer 12 (1), 9-22, 2012 | 2065 | 2012 |
| The tumor microenvironment NM Anderson, MC Simon Current Biology 30 (16), R921-R925, 2020 | 1996 | 2020 |
| Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease JE Durbin, R Hackenmiller, MC Simon, DE Levy Cell 84 (3), 443-450, 1996 | 1981 | 1996 |
| Requirement of transcription factor PU. 1 in the development of multiple hematopoietic lineages EW Scott, MC Simon, J Anastasi, H Singh Science 265 (5178), 1573-1577, 1994 | 1959 | 1994 |
| Mop3 is an essential component of the master circadian pacemaker in mammals MK Bunger, LD Wilsbacher, SM Moran, C Clendenin, LA Radcliffe, ... Cell 103 (7), 1009-1017, 2000 | 1935 | 2000 |
| The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues T Lindsten, AJ Ross, A King, WX Zong, JC Rathmell, HA Shiels, E Ulrich, ... Molecular cell 6 (6), 1389-1399, 2000 | 1873 | 2000 |
| Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation CJ Hu, LY Wang, LA Chodosh, B Keith, MC Simon Molecular and cellular biology 23 (24), 9361-9374, 2003 | 1823 | 2003 |
| Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing RD Guzy, B Hoyos, E Robin, H Chen, L Liu, KD Mansfield, MC Simon, ... Cell metabolism 1 (6), 401-408, 2005 | 1760 | 2005 |
| The impact of O2 availability on human cancer JA Bertout, SA Patel, MC Simon Nature Reviews Cancer 8 (12), 967-975, 2008 | 1705 | 2008 |
| Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 L Pevny, MC Simon, E Robertson, WH Klein, SF Tsai, V D'Agati, SH Orkin, ... Nature 349 (6306), 257-260, 1991 | 1649 | 1991 |
| Hypoxia-induced angiogenesis: good and evil BL Krock, N Skuli, MC Simon Genes & cancer 2 (12), 1117-1133, 2011 | 1426 | 2011 |
| Hypoxia-inducible factors, stem cells, and cancer B Keith, MC Simon Cell 129 (3), 465-472, 2007 | 1385 | 2007 |
| The role of oxygen availability in embryonic development and stem cell function MC Simon, B Keith Nature reviews Molecular cell biology 9 (4), 285-296, 2008 | 1187 | 2008 |
| Stabilization of wild-type p53 by hypoxia-inducible factor 1α WG An, M Kanekal, MC Simon, E Maltepe, MV Blagosklonny, LM Neckers Nature 392 (6674), 405-408, 1998 | 1169 | 1998 |
| Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. JV Schmidt, GH Su, JK Reddy, MC Simon, CA Bradfield Proceedings of the National Academy of Sciences 93 (13), 6731-6736, 1996 | 1147 | 1996 |
| Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability DR Wise, PS Ward, JES Shay, JR Cross, JJ Gruber, UM Sachdeva, ... Proceedings of the National Academy of Sciences 108 (49), 19611-19616, 2011 | 1136 | 2011 |
| HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth KL Covello, J Kehler, H Yu, JD Gordan, AM Arsham, CJ Hu, PA Labosky, ... Genes & development 20 (5), 557-570, 2006 | 1107 | 2006 |