| Interrogating open issues in cancer precision medicine with patient-derived xenografts AT Byrne, DG Alférez, F Amant, D Annibali, J Arribas, AV Biankin, A Bruna, ... Nature Reviews Cancer 17 (4), 254-268, 2017 | 722 | 2017 |
| Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines A Schlicker, G Beran, CM Chresta, G McWalter, A Pritchard, S Weston, ... BMC medical genomics 5, 1-15, 2012 | 314 | 2012 |
| Patient-derived xenograft (PDX) models in basic and translational breast cancer research LE Dobrolecki, SD Airhart, DG Alferez, S Aparicio, F Behbod, ... Cancer and Metastasis Reviews 35, 547-573, 2016 | 286 | 2016 |
| Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity BM Simoes, CS O’Brien, R Eyre, A Silva, L Yu, A Sarmiento-Castro, ... Cell reports 12 (12), 1968-1977, 2015 | 202 | 2015 |
| Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling R Eyre, DG Alférez, A Santiago-Gómez, K Spence, JC McConnell, C Hart, ... Nature communications 10 (1), 5016, 2019 | 136 | 2019 |
| The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models SV Holt, A Logie, R Odedra, A Heier, SP Heaton, D Alferez, BR Davies, ... British journal of cancer 106 (5), 858-866, 2012 | 117 | 2012 |
| Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055) SV Holt, A Logie, BR Davies, D Alferez, S Runswick, S Fenton, ... Cancer research 72 (7), 1804-1813, 2012 | 101 | 2012 |
| Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer RA Goodlad, AJ Ryan, SR Wedge, IT Pyrah, D Alferez, R Poulsom, ... Carcinogenesis 27 (10), 2133-2139, 2006 | 67 | 2006 |
| Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts D Lefley, F Howard, F Arshad, S Bradbury, H Brown, C Tulotta, R Eyre, ... Breast Cancer Research 21, 1-21, 2019 | 61 | 2019 |
| Patient-derived mammosphere and xenograft tumour initiation correlates with progression to metastasis R Eyre, DG Alférez, K Spence, M Kamal, FL Shaw, BM Simões, ... Journal of mammary gland biology and neoplasia 21, 99-109, 2016 | 59 | 2016 |
| Detection of Metabolic Alterations in Non-tumor Gastrointestinal Tissue of the ApcMin/+ Mouse by 1H MAS NMR Spectroscopy A Backshall, D Alferez, F Teichert, ID Wilson, RW Wilkinson, RA Goodlad, ... Journal of proteome research 8 (3), 1423-1430, 2009 | 52 | 2009 |
| The role of steroid hormones in breast cancer stem cells BM Simoes, DG Alferez, SJ Howell, RB Clarke Endocrine-related cancer 22 (6), T177-T186, 2015 | 49 | 2015 |
| The role of steroid hormones in breast and effects on cancer stem cells DG Alferez, BM Simões, SJ Howell, RB Clarke Current stem cell reports 4, 81-94, 2018 | 47 | 2018 |
| Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in ApcMin/+ mice D Alferez, RW Wilkinson, J Watkins, R Poulsom, N Mandir, SR Wedge, ... Molecular cancer therapeutics 7 (3), 590-598, 2008 | 45 | 2008 |
| Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer BM Simões, A Santiago-Gómez, C Chiodo, T Moreira, D Conole, S Lovell, ... Oncogene 39 (25), 4896-4908, 2020 | 38 | 2020 |
| Interrogating open issues in cancer medicine with patient-derived xenografts AT Byrne, DG Alferez, F Amant, D Annibali, J Arribas, AV Biankin, A Bruna, ... Nature Reviews Cancer 17 (10), 632-633, 2017 | 34 | 2017 |
| Phase I study of onapristone, a type I antiprogestin, in female patients with previously treated recurrent or metastatic progesterone receptor-expressing cancers PH Cottu, J Bonneterre, A Varga, M Campone, A Leary, A Floquet, ... PLoS One 13 (10), e0204973, 2018 | 33 | 2018 |
| To best measure cell proliferation in samples from the intestine D Alferez, RA Goodlad Cell Proliferation 40 (2), 231-240, 2007 | 22 | 2007 |
| Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia DG Alferez, RA Goodlad, R Odedra, P Sini, C Crafter, AJ Ryan, ... International journal of oncology 41 (4), 1475-1485, 2012 | 16 | 2012 |
| RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells F Chen, SB Gurler, D Novo, C Selli, DG Alferez, S Eroglu, K Pavlou, ... Oncogene 42 (9), 679-692, 2023 | 9 | 2023 |
Bruno M. SimõesUniversity of ManchesterCorreu electrònic verificat a ics.manchester.ac.uk
