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Dharmin Rokad
Dharmin Rokad
Study Director-Manager, Covance/Labcorp Drug Development
Correu electrònic verificat a labcorp.com
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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease
S Sarkar, E Malovic, DS Harishchandra, S Ghaisas, N Panicker, A Charli, ...
npj Parkinson's Disease 3 (1), 30, 2017
2522017
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
N Panicker, S Sarkar, DS Harischandra, M Neal, TI Kam, H Jin, ...
Journal of Experimental Medicine 216 (6), 1411-1430, 2019
2362019
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
DS Harischandra, D Rokad, ML Neal, S Ghaisas, S Manne, S Sarkar, ...
Science signaling 12 (572), eaau4543, 2019
1672019
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes
S Sarkar, E Malovic, DS Harischandra, HA Ngwa, A Ghosh, C Hogan, ...
Neurotoxicology 64, 204-218, 2018
1452018
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
S Sarkar, D Rokad, E Malovic, J Luo, DS Harischandra, H Jin, ...
Science Signaling 12 (563), eaat9900, 2019
1372019
Kv1. 3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease
S Sarkar, HM Nguyen, E Malovic, J Luo, M Langley, BN Palanisamy, ...
The Journal of clinical investigation 130 (8), 4195-4212, 2020
1242020
Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events
N Singh, V Lawana, J Luo, P Phong, A Abdalla, B Palanisamy, D Rokad, ...
Neurobiology of disease 117, 82-113, 2018
1072018
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal …
DS Harischandra, S Ghaisas, D Rokad, M Zamanian, H Jin, ...
Neurotoxicology 64, 267-277, 2018
1042018
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease
R Gordon, N Singh, V Lawana, A Ghosh, DS Harischandra, H Jin, ...
Neurobiology of disease 93, 96-114, 2016
1032016
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation
D Rokad, S Ghaisas, DS Harischandra, H Jin, V Anantharam, ...
Brain research bulletin 133, 60-70, 2017
682017
Exosomes in toxicology: relevance to chemical exposure and pathogenesis of environmentally linked diseases
DS Harischandra, S Ghaisas, D Rokad, AG Kanthasamy
Toxicological Sciences 158 (1), 3-13, 2017
562017
Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease
DS Harischandra, D Rokad, S Ghaisas, S Verma, A Robertson, H Jin, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (4), 165533, 2020
372020
Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults
S Sarkar, E Malovic, D Sarda, V Lawana, D Rokad, H Jin, V Anantharam, ...
Neurotoxicology 67, 129-140, 2018
332018
Exosomes as mediators of chemical-induced toxicity
D Rokad, H Jin, V Anantharam, A Kanthasamy, AG Kanthasamy
Current environmental health reports 6, 73-79, 2019
252019
Disruption of intracellular signaling
A Kanthasamy, J Luo, D Rokad, A Charli
An Introduction to Interdisciplinary Toxicology, 81-96, 2020
32020
Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms
D Rokad, DS Harischandra, M Samidurai, YT Chang, J Luo, V Lawana, ...
International Journal of Molecular Sciences 25 (22), 12207, 2024
12024
Epitranscriptomic reader YTHDF2 regulates SEK1 (MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress
E Malovic, A Ealy, C Miller, A Jang, PJ Hsu, S Sarkar, D Rokad, C Goeser, ...
Iscience 27 (9), 2024
12024
Role of Manganese Toxicity on Endosomal Trafficking, Exosomal Proteins and Potential Biomarkers Identification for Parkinson’s Disease
DD Rokad
Iowa State University, 2020
2020
Manganese Exposure Induces the Release of Exosomes Containing Misfolded alpha-Synuclein by Impairing Endosomal Trafficking and Protein Degradation Machinery
DD Rokad, D Harischandra, D Luo, S Sarkar, VJ Lawana, D Kim, H Jin, ...
International Journal of Toxicology 39 (1), 48-48, 2020
2020
Role of neurotoxicants and traumatic brain injury in-synuclein protein misfolding and aggregation
D Rokad, S Ghaisas, DS Harischandra, H Jin, V Anantharam, ...
2016
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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