Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors J Wang, J Zhuang, S Iyer, XY Lin, TW Whitfield, MC Greven, BG Pierce, ... Genome research 22 (9), 1798-1812, 2012 | 1086 | 2012 |
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates K Musunuru, AC Chadwick, T Mizoguchi, SP Garcia, JE DeNizio, ... Nature 593 (7859), 429-434, 2021 | 628 | 2021 |
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors J Grünewald, R Zhou, SP Garcia, S Iyer, CA Lareau, MJ Aryee, JK Joung Nature 569 (7756), 433-437, 2019 | 606 | 2019 |
CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells IC Kurt, R Zhou, S Iyer, SP Garcia, BR Miller, LM Langner, J Grünewald, ... Nature biotechnology 39 (1), 41-46, 2021 | 533 | 2021 |
Cancer-specific retargeting of BAF complexes by a prion-like domain G Boulay, GJ Sandoval, N Riggi, S Iyer, R Buisson, B Naigles, ME Awad, ... Cell 171 (1), 163-178. e19, 2017 | 447 | 2017 |
Factorbook. org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium J Wang, J Zhuang, S Iyer, XY Lin, MC Greven, BH Kim, J Moore, ... Nucleic acids research 41 (D1), D171-D176, 2012 | 446 | 2012 |
CRISPR DNA base editors with reduced RNA off-target and self-editing activities J Grünewald, R Zhou, S Iyer, CA Lareau, SP Garcia, MJ Aryee, JK Joung Nature biotechnology 37 (9), 1041-1048, 2019 | 322 | 2019 |
A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing J Grünewald, R Zhou, CA Lareau, SP Garcia, S Iyer, BR Miller, ... Nature biotechnology 38 (7), 861-864, 2020 | 241 | 2020 |
Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing Q Tang, S Iyer, R Lobbardi, JC Moore, H Chen, C Lareau, C Hebert, ... Journal of Experimental Medicine 214 (10), 2875-2887, 2017 | 182 | 2017 |
Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer SE Johnstone, A Reyes, Y Qi, C Adriaens, E Hegazi, K Pelka, JH Chen, ... Cell 182 (6), 1474-1489. e23, 2020 | 180 | 2020 |
The macrophage‐expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish G Ferrero, E Gomez, S Lyer, M Rovira, M Miserocchi, DM Langenau, ... Journal of leukocyte biology 107 (3), 431-443, 2020 | 89 | 2020 |
Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma MN Hayes, K McCarthy, A Jin, ML Oliveira, S Iyer, SP Garcia, S Sindiri, ... Cell stem cell 22 (3), 414-427. e6, 2018 | 74 | 2018 |
Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies G Boulay, A Volorio, S Iyer, LC Broye, I Stamenkovic, N Riggi, MN Rivera Genes & development 32 (15-16), 1008-1019, 2018 | 70 | 2018 |
OTX2 activity at distal regulatory elements shapes the chromatin landscape of group 3 medulloblastoma G Boulay, ME Awad, N Riggi, TC Archer, S Iyer, WE Boonseng, ... Cancer discovery 7 (3), 288-301, 2017 | 69 | 2017 |
The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics W Giblin, L Bringman-Rodenbarger, AH Guo, S Kumar, AC Monovich, ... The Journal of Clinical Investigation, 2021 | 37 | 2021 |
LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma T Keskin, A Bakaric, P Waszyk, G Boulay, M Torsello, S Cornaz-Buros, ... Cell Reports 31 (2), 2020 | 28 | 2020 |
LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability T Keskin, A Bakaric, P Waszyk, G Boulay, M Torsello, S Cornaz-Buros, ... Cell Reports 30 (13), 4567-4583. e5, 2020 | 28 | 2020 |
Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia EG Garcia, S Iyer, SP Garcia, S Loontiens, RI Sadreyev, F Speleman, ... Leukemia 32 (8), 1860-1865, 2018 | 28 | 2018 |
Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects K Petri, DY Kim, KE Sasaki, MC Canver, X Wang, H Shah, H Lee, ... bioRxiv, 2021 | 27 | 2021 |
Augmenting and directing long-range CRISPR-mediated activation in human cells YE Tak, JE Horng, NT Perry, HT Schultz, S Iyer, Q Yao, LS Zou, MJ Aryee, ... Nature Methods, 1-7, 2021 | 26 | 2021 |