| A platform of synthetic lethal gene interaction networks reveals that the GNAQ uveal melanoma oncogene controls the hippo pathway through FAK X Feng, N Arang, DC Rigiracciolo, JS Lee, H Yeerna, Z Wang, S Lubrano, ... Cancer cell 35 (3), 457-472. e5, 2019 | 231 | 2019 |
| The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies D Martin, MC Abba, AA Molinolo, L Vitale-Cross, Z Wang, M Zaida, ... Oncotarget 5 (19), 8906, 2014 | 215 | 2014 |
| Assembly and activation of the Hippo signalome by FAT1 tumor suppressor D Martin, MS Degese, L Vitale-Cross, R Iglesias-Bartolome, JLC Valera, ... Nature communications 9 (1), 2372, 2018 | 170 | 2018 |
| Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4 Z Wang, VH Wu, MM Allevato, M Gilardi, Y He, J Luis Callejas-Valera, ... Nature communications 10 (1), 5546, 2019 | 147 | 2019 |
| YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity Y Yuan, J Park, A Feng, P Awasthi, Z Wang, Q Chen, ... Nature communications 11 (1), 1472, 2020 | 125 | 2020 |
| mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations Z Wang, D Martin, AA Molinolo, V Patel, R Iglesias-Bartolome, ... Journal of the National Cancer Institute 106 (9), dju215, 2014 | 116 | 2014 |
| Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas M Gilardi, Z Wang, M Proietto, A Chillà, JL Calleja-Valera, Y Goto, ... Molecular cancer therapeutics 19 (9), 1784-1796, 2020 | 106 | 2020 |
| Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury Z Wang, Y Wang, Z Wang, JS Gutkind, Z Wang, F Wang, J Lu, G Niu, ... Stem Cells 33 (2), 456-467, 2015 | 100 | 2015 |
| Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells M O'Hayre, A Inoue, I Kufareva, Z Wang, CM Mikelis, RA Drummond, ... Oncogene 35 (29), 3771-3780, 2016 | 93 | 2016 |
| Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC R Saddawi-Konefka, A O’Farrell, F Faraji, L Clubb, MM Allevato, ... Nature communications 13 (1), 4298, 2022 | 91 | 2022 |
| HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers S Ren, DA Gaykalova, T Guo, AV Favorov, EJ Fertig, P Tamayo, ... Oncogene 39 (40), 6327-6339, 2020 | 91 | 2020 |
| Inhibition of mTOR signaling and clinical activity of rapamycin in head and neck cancer in a window of opportunity trial TA Day, K Shirai, PE O'Brien, MG Matheus, K Godwin, AJ Sood, ... Clinical Cancer Research 25 (4), 1156-1164, 2019 | 91 | 2019 |
| SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis P Dillenburg-Pilla, V Patel, CM Mikelis, CR Zárate-Bladés, CL Doçi, ... The FASEB Journal 29 (3), 1056, 2015 | 90 | 2015 |
| Dual-functional guanosine-based hydrogel integrating localized delivery and anticancer activities for cancer therapy H Zhao, H Feng, J Liu, F Tang, Y Du, N Ji, L Xie, X Zhao, Z Wang, Q Chen Biomaterials 230, 119598, 2020 | 88 | 2020 |
| mTOR co-targeting strategies for head and neck cancer therapy Z Wang, JC Valera, X Zhao, Q Chen, J Silvio Gutkind Cancer and Metastasis Reviews 36, 491-502, 2017 | 80 | 2017 |
| 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer Z Wang, X Feng, AA Molinolo, D Martin, L Vitale-Cross, N Nohata, M Ando, ... Cancer research 79 (7), 1438-1450, 2019 | 72 | 2019 |
| Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts J Li, C Gong, X Feng, X Zhou, X Xu, L Xie, R Wang, D Zhang, H Wang, ... PLoS One 7 (4), e33860, 2012 | 61 | 2012 |
| Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer Z Wang, Y Goto, MM Allevato, VH Wu, R Saddawi-Konefka, M Gilardi, ... Nature communications 12 (1), 2383, 2021 | 59 | 2021 |
| A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity DL Swaney, DJ Ramms, Z Wang, J Park, Y Goto, M Soucheray, N Bhola, ... Science 374 (6563), eabf2911, 2021 | 58 | 2021 |
| Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions JS Gutkind, AA Molinolo, X Wu, Z Wang, D Nachmanson, O Harismendy, ... JCI insight 6 (17), 2021 | 57 | 2021 |
J. Silvio Gutkind, Ph.D.UCSD, Distinguished Professor and Chair, Dept. Pharmacology, AD Basic Science Moores Cancer CenterCorreu electrònic verificat a ucsd.edu
