Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes JR Lindsay, NA Duffy, AM McKillop, J Ardill, FPM O'Harte, PR Flatt, ... Diabetic Medicine 22 (5), 654-657, 2005 | 270 | 2005 |
Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycemic-hyperinsulinemic clamp technique in humans SJ Hunter, AC Boyd, FPM O’Harte, AM McKillop, MI Wiggam, MH Mooney, ... Diabetes 52 (2), 492-498, 2003 | 149 | 2003 |
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta‐cells, isolated pancreatic islets and mice AM McKillop, BM Moran, YHA Abdel‐Wahab, PR Flatt British journal of pharmacology 170 (5), 978-990, 2013 | 102 | 2013 |
Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle AC Boyd, YHA Abdel-Wahab, AM McKillop, H McNulty, CR Barnett, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1523 (1), 128-134, 2000 | 84 | 2000 |
Evaluation of the insulin‐releasing and glucose‐lowering effects of GPR120 activation in pancreatic β‐cells BM Moran, YHA Abdel‐Wahab, PR Flatt, AM McKillop Diabetes, Obesity and Metabolism 16 (11), 1128-1139, 2014 | 70 | 2014 |
Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1 NA Duffy, BD Green, N Irwin, VA Gault, AM McKillop, FPM O'Harte, ... European journal of pharmacology 568 (1-3), 278-286, 2007 | 70 | 2007 |
Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1 (7-36) amide degradation in type 2 diabetic subjects AM McKillop, NA Duffy, JR Lindsay, FPM O’Harte, PM Bell, PR Flatt Diabetes research and clinical practice 79 (1), 79-85, 2008 | 68 | 2008 |
G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis BM Moran, PR Flatt, AM McKillop Acta diabetologica 53, 177-188, 2016 | 61 | 2016 |
Emerging applications of metabolomic and genomic profiling in diabetic clinical medicine AM McKillop, PR Flatt Diabetes Care 34 (12), 2624-2630, 2011 | 61 | 2011 |
Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety AI Taylor, N Irwin, AM McKillop, S Patterson, PR Flatt, VA Gault Journal of endocrinology 207 (1), 87, 2010 | 59 | 2010 |
40th EASD Annual Meeting of the European Association for the Study of Diabetes: Munich, Germany, 5–9 September 2004 M Veitenhansl, K Stegner, FX Hierl, C Dieterle, H Feldmeier, B Gutt, ... Diabetologia 47, A1-A464, 2004 | 56 | 2004 |
Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice AM McKillop, BM Moran, YHA Abdel-Wahab, NM Gormley, PR Flatt Diabetologia 59, 2674-2685, 2016 | 53 | 2016 |
Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice BM Moran, YHA Abdel-Wahab, PR Flatt, AM McKillop Biological chemistry 395 (4), 453-464, 2014 | 52 | 2014 |
Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes AI Taylor, N Frizzell, AM McKillop, PR Flatt, VA Gault Hormone and metabolic research 41 (12), 899-904, 2009 | 42 | 2009 |
Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay JR Lindsay, AM McKillop, MH Mooney, FPM O'Harte, PM Bell, PR Flatt Diabetologia 46, 475-478, 2003 | 42 | 2003 |
Degradation and glycemic effects of His7-glucitol glucagon-like peptide-1 (7–36) amide in obese diabetic ob/ob mice FPM O’Harte, MH Mooney, CMN Kelly, AM McKillop, PR Flatt Regulatory peptides 96 (3), 95-104, 2001 | 36 | 2001 |
Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin FPM O’Harte, AC Boyd, AM McKillop, YHA Abdel-Wahab, H McNulty, ... Peptides 21 (10), 1519-1526, 2000 | 35 | 2000 |
Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity A Taylor, N Irwin, AM McKillop, PR Flatt, VA Gault Walter de Gruyter 389 (4), 441-445, 2008 | 32 | 2008 |
Secretion of glycated insulin from pancreatic beta-cells in diabetes represents a novel aspect of beta-cell dysfunction and glucose toxicity. AM McKillop, YH Abdel-Wahab, MH Mooney, FP O'Harte, PR Flatt Diabetes & metabolism 28 (6 Pt 2), 3S61-9; discussion 3S108, 2002 | 31 | 2002 |
Development of novel ligands for peptide GPCRs BM Moran, AM McKillop, FPM O’Harte Current opinion in pharmacology 31, 57-62, 2016 | 29 | 2016 |