| Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC KB Wang, MSA Elsayed, G Wu, N Deng, M Cushman, D Yang Journal of the American Chemical Society 141 (28), 11059-11070, 2019 | 90 | 2019 |
| Synthesis and biological evaluation of the first triple inhibitors of human topoisomerase 1, tyrosyl–DNA phosphodiesterase 1 (Tdp1), and tyrosyl–DNA phosphodiesterase 2 (Tdp2) P Wang, MSA Elsayed, CB Plescia, A Ravji, CE Redon, E Kiselev, ... Journal of medicinal chemistry 60 (8), 3275-3288, 2017 | 60 | 2017 |
| Design, synthesis, and biological evaluation of potential prodrugs related to the experimental anticancer agent indotecan (LMP400) PC Lv, MSA Elsayed, K Agama, C Marchand, Y Pommier, M Cushman Journal of medicinal chemistry 59 (10), 4890-4899, 2016 | 52 | 2016 |
| Structure-based design and synthesis of novel pseudosaccharine derivatives as antiproliferative agents and kinase inhibitors MSA Elsayed, ME El-Araby, RAT Serya, AH El-Khatib, MW Linscheid, ... European Journal of Medicinal Chemistry 61, 122-131, 2013 | 44 | 2013 |
| SHP2 inhibition sensitizes diverse oncogene-addicted solid tumors to re-treatment with targeted therapy A Drilon, MR Sharma, ML Johnson, TA Yap, S Gadgeel, D Nepert, G Feng, ... Cancer discovery 13 (8), 1789-1801, 2023 | 41 | 2023 |
| Novel fluoroindenoisoquinoline non-camptothecin topoisomerase I inhibitors MCYP Laetitia Marzi, Keli Agama, Junko Murai, Simone Difilippantonio, Amy ... Molecular cancer Therapeutics, 2018 | 38 | 2018 |
| Design and synthesis of chlorinated and fluorinated 7-azaindenoisoquinolines as potent cytotoxic anticancer agents that inhibit topoisomerase I MSA Elsayed, Y Su, P Wang, T Sethi, K Agama, A Ravji, CE Redon, ... Journal of medicinal chemistry 60 (13), 5364-5376, 2017 | 36 | 2017 |
| Synthesis of Benzo[1,6]naphthyridinones Using the Catellani Reaction MSA Elsayed, B Griggs, M Cushman Organic Letters 20, 5228−5232, 2018 | 29 | 2018 |
| Design, synthesis and molecular modeling study of certain 4-Methylbenzenesulfonamides with CDK2 inhibitory activity as anticancer and radio-sensitizing agents WMG Mostafa M.Ghorab, Fatma A.Ragab, Helmy I.Heiba, Mohamed S.A.Elsayed Bioorganic Chemistry 80, 276-287, 2018 | 20 | 2018 |
| Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[c]pyrrolo[2,3-h][1,6]naphthyridin-5-one (BPN) Series MC Mohamed SA Elsayed, Jeffery J Nielsen, Sungtae Park, Jeongho Park ... Journal of Medicinal Chemistry 61 (23), 10440-10462, 2018 | 17 | 2018 |
| Applying ligands profiling using multiple extended electron distribution based field templates and feature trees similarity searching in the discovery of new generation of urea … EM Dokla, AH Mahmoud, MSA Elsayed, AH El-Khatib, MW Linscheid, ... Plos one 7 (11), e49284, 2012 | 11 | 2012 |
| Ligand-free, palladacycle-facilitated Suzuki coupling of hindered 2-arylbenzothiazole derivatives yields potent and selective COX-2 inhibitors MSA Elsayed, S Chang, M Cushman Organic & biomolecular chemistry 16 (1), 108-118, 2018 | 10 | 2018 |
| Synthesis of indolo[4,3-bc]phenanthridine-6,11(2H,12H)-diones using the schiff base–homophthalic anhydride cyclization reaction MSA Elsayed, M Zeller, M Cushman Synthetic communications 46 (23), 1902-1908, 2016 | 9 | 2016 |
| Structure-based predictive model for some benzimidazole inhibitors of hepatitis C virus NS5B polymerase AH Mahmoud, MSA Elsayed, M ElHefnawi Medicinal Chemistry Research 22, 1866-1883, 2013 | 9 | 2013 |
| New inhibitors of VEGFR-2 targeting the extracellular domain dimerization process MA ElGamacy, RA Shalaby, AT Elkodsh, AF Kamel, MSA Elsayed, ... Bioinformation 7 (2), 52, 2011 | 7 | 2011 |
| Virtual screening and synthesis of new chemical scaffolds as VEGFR-2 kinase inhibitors MS Elsayed, ME El-Araby, RT Serya, KAM Abouzid Arzneimittelforschung 62 (12), 554-560, 2012 | 4 | 2012 |
| Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors MSA Elsayed, JF Blake, ML Boys, E Brown, BD Chapsal, MJ Chicarelli, ... ACS Medicinal Chemistry Letters 14 (12), 1673-1681, 2023 | 3 | 2023 |
| Protein tyrosine phosphatase inhibitors JF Blake, ML Boys, MJ Chicarelli, AW Cook, MSA ELSAYED, JB Fell, ... | 3 | 2020 |
| Azaindenoisoquinoline compounds and uses thereof MS Cushman, P Wang, YG POMMIER, MSA ELSAYED | 3 | 2018 |
| Delta-opioid receptor agonists RM Van Rijn, MS Cushman, M Lill, RJ Cassell, AHM Abdallah, ... US Patent 10,954,224, 2021 | 1 | 2021 |
Mark CushmanPurdue UniversityCorreu electrònic verificat a purdue.edu