The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling AV Shinde, C Humeres, NG Frangogiannis Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (1), 298-309, 2017 | 545 | 2017 |
Fibroblasts in the infarcted, remodeling, and failing heart C Humeres, NG Frangogiannis JACC: Basic to Translational Science 4 (3), 449-467, 2019 | 367 | 2019 |
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart M Ibacache, G Sanchez, Z Pedrozo, F Galvez, C Humeres, G Echevarria, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (4), 537-545, 2012 | 190 | 2012 |
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol P Ayala, J Montenegro, R Vivar, A Letelier, PA Urroz, M Copaja, D Pivet, ... Experimental and molecular pathology 92 (1), 97-104, 2012 | 154 | 2012 |
Properties and functions of fibroblasts and myofibroblasts in myocardial infarction H Venugopal, A Hanna, C Humeres, NG Frangogiannis Cells 11 (9), 1386, 2022 | 130 | 2022 |
Myocardial galectin-3 expression is associated with remodeling of the pressure-overloaded heart and may delay the hypertrophic response without affecting survival, dysfunction … O Frunza, I Russo, A Saxena, AV Shinde, C Humeres, W Hanif, V Rai, ... The American journal of pathology 186 (5), 1114-1127, 2016 | 112 | 2016 |
The role of Smad signaling cascades in cardiac fibrosis A Hanna, C Humeres, NG Frangogiannis Cellular signalling 77, 109826, 2021 | 105 | 2021 |
Cardiac fibroblasts as sentinel cells in cardiac tissue: Receptors, signaling pathways and cellular functions G Díaz-Araya, R Vivar, C Humeres, P Boza, S Bolivar, C Muñoz Pharmacological research 101, 30-40, 2015 | 94 | 2015 |
Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure C Humeres, AV Shinde, A Hanna, L Alex, SC Hernández, R Li, B Chen, ... The Journal of clinical investigation 132 (3), 2022 | 87 | 2022 |
IFN-β plays both pro-and anti-inflammatory roles in the rat cardiac fibroblast through differential STAT protein activation S Bolívar, R Anfossi, C Humeres, R Vivar, P Boza, C Muñoz, ... Frontiers in pharmacology 9, 1368, 2018 | 78 | 2018 |
Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro C Humeres, R Vivar, P Boza, C Muñoz, S Bolivar, R Anfossi, JM Osorio, ... Journal of molecular and cellular cardiology 101, 69-80, 2016 | 78 | 2016 |
Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart S Huang, B Chen, Y Su, L Alex, C Humeres, AV Shinde, SJ Conway, ... Journal of molecular and cellular cardiology 132, 84-97, 2019 | 77 | 2019 |
FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation R Vivar, C Humeres, C Muñoz, P Boza, S Bolivar, F Tapia, S Lavandero, ... Biochimica Et Biophysica Acta (BBA)-Molecular Cell Research 1863 (1), 128-138, 2016 | 76 | 2016 |
TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways R Vivar, C Humeres, P Ayala, I Olmedo, M Catalán, L García, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (6), 754-762, 2013 | 69 | 2013 |
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1β synthesis, secretion, and degradation P Boza, P Ayala, R Vivar, C Humeres, FT Cáceres, C Muñoz, L García, ... Molecular immunology 74, 96-105, 2016 | 61 | 2016 |
Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression F Olivares-Silva, R Landaeta, P Aránguiz, S Bolivar, C Humeres, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (3), 831-842, 2018 | 47 | 2018 |
The role of Smad2 and Smad3 in regulating homeostatic functions of fibroblasts in vitro and in adult mice S Huang, B Chen, C Humeres, L Alex, A Hanna, NG Frangogiannis Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1867 (7), 118703, 2020 | 44 | 2020 |
Cardiac pericytes acquire a fibrogenic phenotype and contribute to vascular maturation after myocardial infarction L Alex, I Tuleta, SC Hernandez, A Hanna, H Venugopal, M Astorkia, ... Circulation 148 (11), 882-898, 2023 | 32 | 2023 |
Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1 R Vivar, C Humeres, R Anfossi, S Bolivar, M Catalán, J Hill, S Lavandero, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1867 (7), 118695, 2020 | 28 | 2020 |
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK–ERK pathways R Vivar, C Humeres, M Varela, P Ayala, N Guzmán, I Olmedo, M Catalán, ... Experimental and molecular pathology 93 (1), 1-7, 2012 | 27 | 2012 |