High-dose ampicillin-sulbactam combinations combat polymyxin-resistant Acinetobacter baumannii in a hollow-fiber infection model JR Lenhard, NM Smith, ZP Bulman, X Tao, V Thamlikitkul, BS Shin, ... Antimicrobial Agents and Chemotherapy 61 (3), 10.1128/aac. 01268-16, 2017 | 82 | 2017 |
Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection … TP Lodise, NM Smith, N O’Donnell, AE Eakin, PN Holden, ... Journal of Antimicrobial Chemotherapy 75 (9), 2622-2632, 2020 | 66 | 2020 |
Optimizing polymyxin combinations against resistant Gram-negative bacteria PJ Bergen, ZP Bulman, CB Landersdorfer, N Smith, JR Lenhard, ... Infectious Diseases and Therapy 4, 391-415, 2015 | 54 | 2015 |
FL118, a novel camptothecin analogue, overcomes irinotecan and topotecan resistance in human tumor xenograft models X Ling, X Liu, K Zhong, N Smith, J Prey, F Li American journal of translational research 7 (10), 1765, 2015 | 53 | 2015 |
Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii NM Smith, JR Lenhard, KR Boissonneault, CB Landersdorfer, JB Bulitta, ... Clinical Microbiology and Infection 26 (9), 1207-1213, 2020 | 48 | 2020 |
Rational combinations of polymyxins with other antibiotics PJ Bergen, NM Smith, TB Bedard, ZP Bulman, R Cha, BT Tsuji Polymyxin antibiotics: from laboratory bench to bedside, 251-288, 2019 | 33 | 2019 |
Evaluating the effect of six proton pump inhibitors on the antiplatelet effects of clopidogrel ER Przespolewski, ES Westphal, M Rainka, NM Smith, V Bates, ... Journal of Stroke and Cerebrovascular Diseases 27 (6), 1582-1589, 2018 | 24 | 2018 |
Interaction of Staphylococcus aureus and Acinetobacter baumannii during In Vitro β-Lactam Exposure NM Smith, A Ang, F Tan, K Macias, S James, J Sidhu, JR Lenhard Antimicrobial Agents and Chemotherapy 65 (4), 10.1128/aac. 02414-20, 2021 | 23 | 2021 |
Pharmacodynamics of dose-escalated ‘front-loading’ polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli NM Smith, ZP Bulman, AO Sieron, JB Bulitta, PN Holden, RL Nation, J Li, ... Journal of Antimicrobial Chemotherapy 72 (8), 2297-2303, 2017 | 18 | 2017 |
In Pursuit of the Triple Crown: Mechanism-Based Pharmacodynamic Modelling for the Optimization of Three-Drug Combinations Against KPC-producing Klebsiella Pneumoniae NJ Onufrak, NM Smith, MJ Satlin, JB Bulitta, X Tan, PN Holden, RL Nation, ... Clinical microbiology and infection: the official publication of the …, 2020 | 16 | 2020 |
Combatting the rising tide of antimicrobial resistance: pharmacokinetic/pharmacodynamic dosing strategies for maximal precision HC Chua, A Tse, NM Smith, KA Mergenhagen, R Cha, BT Tsuji International Journal of Antimicrobial Agents 57 (3), 106269, 2021 | 13 | 2021 |
Bacterial brothers in arms: cooperation of Staphylococcus aureus and Pseudomonas aeruginosa during antimicrobial exposure JR Lenhard, NM Smith, CD Quach, TQ Nguyen, LH Doan, J Chau Journal of Antimicrobial Chemotherapy 74 (9), 2657-2665, 2019 | 12 | 2019 |
Mechanistic insights to combating NDM-and CTX-M-coproducing Klebsiella pneumoniae by targeting cell wall synthesis and outer membrane integrity NM Smith, KR Boissonneault, L Chen, V Petraitis, R Petraitiene, X Tao, ... Antimicrobial agents and chemotherapy 66 (9), e00527-22, 2022 | 11 | 2022 |
Next generation antibiotic combinations to combat pan-drug resistant Klebsiella pneumoniae JN Kaur, N Singh, NM Smith, JF Klem, R Cha, Y Lang, L Chen, ... Scientific Reports 14 (1), 3148, 2024 | 8 | 2024 |
A Mechanism-based Pathway Toward Administering Highly Active N-Phage Cocktails NM Smith, TD Nguyen, WH Chin, JT Sanborn, H de Souza, BM Ho, ... Frontiers in Microbiology 14, 1292618, 2023 | 6 | 2023 |
Open‐source maximum a posteriori‐bayesian dosing AdDS to current therapeutic drug monitoring: Adapting to the era of individualized therapy NM Smith, A Chan, LA Wilkinson, HC Chua, TD Nguyen, H de Souza, ... Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 41 (11 …, 2021 | 6 | 2021 |
Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug … J Zhou, Y Qian, Y Lang, Y Zhang, X Tao, B Moya, ARM Sayed, ... Antimicrobial Agents and Chemotherapy 68 (3), e01399-23, 2024 | 3 | 2024 |
Machine learning‐led optimization of combination therapy: confronting the public health threat of extensively drug resistant gram‐negative bacteria NM Smith, TD Nguyen, TP Lodise, L Chen, JN Kaur, JF Klem, ... Clinical Pharmacology & Therapeutics 115 (4), 896-905, 2024 | 2 | 2024 |
1385. Efficacy of Ceftazidime–Avibactam in Combination with Aztreonam (COMBINE): Solutions for Metallo-β-Lactamase Producing-Enterobacteriaceae (MBL) TP Lodise, NM Smith, P Holden, JN O’Donnell, T Bedard, RA Bonomo, ... Open Forum Infectious Diseases 5 (Suppl 1), S425, 2018 | 2 | 2018 |
The development of an in vitro assay for the prospective determination of aspirin sensitivity ES Westphal, C Wisniewski, M Rainka, NM Smith, V Bates, FM Gengo The Journal of Clinical Pharmacology 58 (9), 1150-1156, 2018 | 2 | 2018 |