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Nicholas M. Smith
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High-dose ampicillin-sulbactam combinations combat polymyxin-resistant Acinetobacter baumannii in a hollow-fiber infection model
JR Lenhard, NM Smith, ZP Bulman, X Tao, V Thamlikitkul, BS Shin, ...
Antimicrobial Agents and Chemotherapy 61 (3), 10.1128/aac. 01268-16, 2017
822017
Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection …
TP Lodise, NM Smith, N O’Donnell, AE Eakin, PN Holden, ...
Journal of Antimicrobial Chemotherapy 75 (9), 2622-2632, 2020
662020
Optimizing polymyxin combinations against resistant Gram-negative bacteria
PJ Bergen, ZP Bulman, CB Landersdorfer, N Smith, JR Lenhard, ...
Infectious Diseases and Therapy 4, 391-415, 2015
542015
FL118, a novel camptothecin analogue, overcomes irinotecan and topotecan resistance in human tumor xenograft models
X Ling, X Liu, K Zhong, N Smith, J Prey, F Li
American journal of translational research 7 (10), 1765, 2015
532015
Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii
NM Smith, JR Lenhard, KR Boissonneault, CB Landersdorfer, JB Bulitta, ...
Clinical Microbiology and Infection 26 (9), 1207-1213, 2020
482020
Rational combinations of polymyxins with other antibiotics
PJ Bergen, NM Smith, TB Bedard, ZP Bulman, R Cha, BT Tsuji
Polymyxin antibiotics: from laboratory bench to bedside, 251-288, 2019
332019
Evaluating the effect of six proton pump inhibitors on the antiplatelet effects of clopidogrel
ER Przespolewski, ES Westphal, M Rainka, NM Smith, V Bates, ...
Journal of Stroke and Cerebrovascular Diseases 27 (6), 1582-1589, 2018
242018
Interaction of Staphylococcus aureus and Acinetobacter baumannii during In Vitro β-Lactam Exposure
NM Smith, A Ang, F Tan, K Macias, S James, J Sidhu, JR Lenhard
Antimicrobial Agents and Chemotherapy 65 (4), 10.1128/aac. 02414-20, 2021
232021
Pharmacodynamics of dose-escalated ‘front-loading’ polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli
NM Smith, ZP Bulman, AO Sieron, JB Bulitta, PN Holden, RL Nation, J Li, ...
Journal of Antimicrobial Chemotherapy 72 (8), 2297-2303, 2017
182017
In Pursuit of the Triple Crown: Mechanism-Based Pharmacodynamic Modelling for the Optimization of Three-Drug Combinations Against KPC-producing Klebsiella Pneumoniae
NJ Onufrak, NM Smith, MJ Satlin, JB Bulitta, X Tan, PN Holden, RL Nation, ...
Clinical microbiology and infection: the official publication of the …, 2020
162020
Combatting the rising tide of antimicrobial resistance: pharmacokinetic/pharmacodynamic dosing strategies for maximal precision
HC Chua, A Tse, NM Smith, KA Mergenhagen, R Cha, BT Tsuji
International Journal of Antimicrobial Agents 57 (3), 106269, 2021
132021
Bacterial brothers in arms: cooperation of Staphylococcus aureus and Pseudomonas aeruginosa during antimicrobial exposure
JR Lenhard, NM Smith, CD Quach, TQ Nguyen, LH Doan, J Chau
Journal of Antimicrobial Chemotherapy 74 (9), 2657-2665, 2019
122019
Mechanistic insights to combating NDM-and CTX-M-coproducing Klebsiella pneumoniae by targeting cell wall synthesis and outer membrane integrity
NM Smith, KR Boissonneault, L Chen, V Petraitis, R Petraitiene, X Tao, ...
Antimicrobial agents and chemotherapy 66 (9), e00527-22, 2022
112022
Next generation antibiotic combinations to combat pan-drug resistant Klebsiella pneumoniae
JN Kaur, N Singh, NM Smith, JF Klem, R Cha, Y Lang, L Chen, ...
Scientific Reports 14 (1), 3148, 2024
82024
A Mechanism-based Pathway Toward Administering Highly Active N-Phage Cocktails
NM Smith, TD Nguyen, WH Chin, JT Sanborn, H de Souza, BM Ho, ...
Frontiers in Microbiology 14, 1292618, 2023
62023
Open‐source maximum a posteriori‐bayesian dosing AdDS to current therapeutic drug monitoring: Adapting to the era of individualized therapy
NM Smith, A Chan, LA Wilkinson, HC Chua, TD Nguyen, H de Souza, ...
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 41 (11 …, 2021
62021
Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug …
J Zhou, Y Qian, Y Lang, Y Zhang, X Tao, B Moya, ARM Sayed, ...
Antimicrobial Agents and Chemotherapy 68 (3), e01399-23, 2024
32024
Machine learning‐led optimization of combination therapy: confronting the public health threat of extensively drug resistant gram‐negative bacteria
NM Smith, TD Nguyen, TP Lodise, L Chen, JN Kaur, JF Klem, ...
Clinical Pharmacology & Therapeutics 115 (4), 896-905, 2024
22024
1385. Efficacy of Ceftazidime–Avibactam in Combination with Aztreonam (COMBINE): Solutions for Metallo-β-Lactamase Producing-Enterobacteriaceae (MBL)
TP Lodise, NM Smith, P Holden, JN O’Donnell, T Bedard, RA Bonomo, ...
Open Forum Infectious Diseases 5 (Suppl 1), S425, 2018
22018
The development of an in vitro assay for the prospective determination of aspirin sensitivity
ES Westphal, C Wisniewski, M Rainka, NM Smith, V Bates, FM Gengo
The Journal of Clinical Pharmacology 58 (9), 1150-1156, 2018
22018
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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