| A causative link between the structure of aberrant protein oligomers and their toxicity S Campioni, B Mannini, M Zampagni, A Pensalfini, C Parrini, ... Nature chemical biology 6 (2), 140-147, 2010 | 645 | 2010 |
| Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity B Mannini, E Mulvihill, C Sgromo, R Cascella, R Khodarahmi, ... ACS chemical biology 9 (10), 2309-2317, 2014 | 228 | 2014 |
| Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ... Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017 | 224 | 2017 |
| Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers B Mannini, R Cascella, M Zampagni, M van Waarde-Verhagen, S Meehan, ... Proceedings of the National Academy of Sciences 109 (31), 12479-12484, 2012 | 167 | 2012 |
| Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ... Nature communications 10 (1), 225, 2019 | 157 | 2019 |
| Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ... Science advances 6 (45), eabb5924, 2020 | 139 | 2020 |
| Proteome-wide observation of the phenomenon of life on the edge of solubility G Vecchi, P Sormanni, B Mannini, A Vandelli, GG Tartaglia, CM Dobson, ... Proceedings of the National Academy of Sciences 117 (2), 1015-1020, 2020 | 135 | 2020 |
| Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles Nature Communications 11 (1), 2945, 2020 | 131 | 2020 |
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 117 | 2018 |
| SERS detection of amyloid oligomers on metallorganic-decorated plasmonic beads L Guerrini, R Arenal, B Mannini, F Chiti, R Pini, P Matteini, ... ACS applied materials & interfaces 7 (18), 9420-9428, 2015 | 101 | 2015 |
| Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro R Cascella, S Conti, B Mannini, X Li, JN Buxbaum, B Tiribilli, F Chiti, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013 | 90 | 2013 |
| Rational design of a conformation-specific antibody for the quantification of Aβ oligomers FA Aprile, P Sormanni, M Podpolny, S Chhangur, LM Needham, ... Proceedings of the National Academy of Sciences 117 (24), 13509-13518, 2020 | 80 | 2020 |
| A comparison of the biochemical modifications caused by toxic and non‐toxic protein oligomers in cells M Zampagni, R Cascella, F Casamenti, C Grossi, E Evangelisti, D Wright, ... Journal of cellular and molecular medicine 15 (10), 2106-2116, 2011 | 72 | 2011 |
| Aβ oligomers dysregulate calcium homeostasis by mechanosensitive activation of AMPA and NMDA receptors G Fani, B Mannini, G Vecchi, R Cascella, C Cecchi, CM Dobson, ... ACS Chemical Neuroscience 12 (4), 766-781, 2021 | 67 | 2021 |
| Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils H Ramshini, C Parrini, A Relini, M Zampagni, B Mannini, A Pesce, ... PloS one 6 (1), e16075, 2011 | 64 | 2011 |
| Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, ... Communications biology 3 (1), 435, 2020 | 60 | 2020 |
| Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, ... ACS chemical neuroscience 9 (12), 2959-2971, 2018 | 59 | 2018 |
| Chaperones as suppressors of protein misfolded oligomer toxicity B Mannini, F Chiti Frontiers in molecular neuroscience 10, 98, 2017 | 58 | 2017 |
| Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ... Frontiers in Neuroscience 15, 680026, 2021 | 51 | 2021 |
| A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, ... Communications Biology 4 (1), 19, 2021 | 43 | 2021 |