| Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs J Soutschek, A Akinc, B Bramlage, K Charisse, R Constien, M Donoghue, ... Nature 432 (7014), 173-178, 2004 | 3021 | 2004 |
| Rational design of cationic lipids for siRNA delivery SC Semple, A Akinc, J Chen, AP Sandhu, BL Mui, CK Cho, DWY Sah, ... Nature biotechnology 28 (2), 172-176, 2010 | 2059 | 2010 |
| RNAi-mediated gene silencing in non-human primates TS Zimmermann, ACH Lee, A Akinc, B Bramlage, D Bumcrot, MN Fedoruk, ... Nature 441 (7089), 111-114, 2006 | 1905 | 2006 |
| Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis A Akinc, M Thomas, AM Klibanov, R Langer The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2005 | 1741 | 2005 |
| A combinatorial library of lipid-like materials for delivery of RNAi therapeutics A Akinc, A Zumbuehl, M Goldberg, ES Leshchiner, V Busini, N Hossain, ... Nature biotechnology 26 (5), 561-569, 2008 | 1491 | 2008 |
| Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape J Gilleron, W Querbes, A Zeigerer, A Borodovsky, G Marsico, U Schubert, ... Nature biotechnology 31 (7), 638-646, 2013 | 1473 | 2013 |
| Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo M Jayaraman, SM Ansell, BL Mui, YK Tam, J Chen, X Du, D Butler, ... Angewandte Chemie 124 (34), 8657-8661, 2012 | 1317 | 2012 |
| The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs A Akinc, MA Maier, M Manoharan, K Fitzgerald, M Jayaraman, S Barros, ... Nature nanotechnology 14 (12), 1084-1087, 2019 | 1304 | 2019 |
| Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms A Akinc, W Querbes, S De, J Qin, M Frank-Kamenetsky, KN Jayaprakash, ... Molecular Therapy 18 (7), 1357-1364, 2010 | 1218 | 2010 |
| MicroRNAs 103 and 107 regulate insulin sensitivity M Trajkovski, J Hausser, J Soutschek, B Bhat, A Akin, M Zavolan, ... Nature 474 (7353), 649-653, 2011 | 1157 | 2011 |
| Lipid-like materials for low-dose, in vivo gene silencing KT Love, KP Mahon, CG Levins, KA Whitehead, W Querbes, JR Dorkin, ... Proceedings of the National Academy of Sciences 107 (5), 1864-1869, 2010 | 1157 | 2010 |
| Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing JK Nair, JLS Willoughby, A Chan, K Charisse, MR Alam, Q Wang, ... Journal of the American Chemical Society 136 (49), 16958-16961, 2014 | 1134 | 2014 |
| Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates M Frank-Kamenetsky, A Grefhorst, NN Anderson, TS Racie, B Bramlage, ... Proceedings of the National Academy of Sciences 105 (33), 11915-11920, 2008 | 828 | 2008 |
| In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight JE Dahlman, C Barnes, OF Khan, A Thiriot, S Jhunjunwala, TE Shaw, ... Nature nanotechnology 9 (8), 648-655, 2014 | 710 | 2014 |
| Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics MA Maier, M Jayaraman, S Matsuda, J Liu, S Barros, W Querbes, YK Tam, ... Molecular Therapy 21 (8), 1570-1578, 2013 | 584 | 2013 |
| Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates Y Dong, KT Love, JR Dorkin, S Sirirungruang, Y Zhang, D Chen, ... Proceedings of the National Academy of Sciences 111 (11), 3955-3960, 2014 | 548 | 2014 |
| Structure/property studies of polymeric gene delivery using a library of poly (β-amino esters) DG Anderson, A Akinc, N Hossain, R Langer Molecular Therapy 11 (3), 426-434, 2005 | 502 | 2005 |
| Development of lipidoid–siRNA formulations for systemic delivery to the liver A Akinc, M Goldberg, J Qin, JR Dorkin, C Gamba-Vitalo, M Maier, ... Molecular Therapy 17 (5), 872-879, 2009 | 480 | 2009 |
| Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery A Akinc, DM Lynn, DG Anderson, R Langer Journal of the American Chemical Society 125 (18), 5316-5323, 2003 | 445 | 2003 |
| Lipid formulation J Chen, S Ansell, A Akinc, JR Dorkin, X Qin, W Cantley, M Manoharan, ... US Patent 8,158,601, 2012 | 430 | 2012 |
