| FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis T Matsuzaki, O Alvarez-Garcia, S Mokuda, K Nagira, M Olmer, R Gamini, ... Science translational medicine 10 (428), eaan0746, 2018 | 270 | 2018 |
| Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis KM Fisch, R Gamini, O Alvarez-Garcia, R Akagi, M Saito, Y Muramatsu, ... Osteoarthritis and cartilage 26 (11), 1531-1538, 2018 | 221 | 2018 |
| FoxO transcription factors support oxidative stress resistance in human chondrocytes Y Akasaki, O Alvarez‐Garcia, M Saito, B Caramés, Y Iwamoto, MK Lotz Arthritis & rheumatology 66 (12), 3349-3358, 2014 | 213 | 2014 |
| Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin‐1 O Alvarez‐Garcia, NH Rogers, RG Smith, MK Lotz Arthritis & Rheumatology 66 (7), 1779-1788, 2014 | 120 | 2014 |
| Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2 Y Yamanaka, MA Faghihi, M Magistri, O Alvarez-Garcia, M Lotz, ... Cell reports 11 (6), 967-976, 2015 | 105 | 2015 |
| Elevated oxidative stress in the brain of senescence-accelerated mice at 5 months of age Ó Álvarez-García, I Vega-Naredo, V Sierra, B Caballero, C Tomás-Zapico, ... Biogerontology 7, 43-52, 2006 | 103 | 2006 |
| Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes R Akagi, Y Akatsu, KM Fisch, O Alvarez-Garcia, T Teramura, Y Muramatsu, ... Osteoarthritis and cartilage 25 (6), 943-951, 2017 | 95 | 2017 |
| Regulated in development and DNA damage response 1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental … O Alvarez‐Garcia, T Matsuzaki, M Olmer, L Plate, JW Kelly, MK Lotz Arthritis & rheumatology 69 (7), 1418-1428, 2017 | 88 | 2017 |
| MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins S D'Adamo, O Alvarez-Garcia, Y Muramatsu, F Flamigni, MK Lotz Osteoarthritis and Cartilage 24 (6), 1082-1091, 2016 | 87 | 2016 |
| Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage O Alvarez‐Garcia, KM Fisch, NE Wineinger, R Akagi, M Saito, T Sasho, ... Arthritis & rheumatology 68 (8), 1876-1886, 2016 | 76 | 2016 |
| FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis KI Lee, S Choi, T Matsuzaki, O Alvarez-Garcia, M Olmer, SP Grogan, ... Proceedings of the National Academy of Sciences 117 (6), 3135-3143, 2020 | 75 | 2020 |
| FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration O Alvarez‐Garcia, T Matsuzaki, M Olmer, K Miyata, S Mokuda, D Sakai, ... Aging cell 17 (5), e12800, 2018 | 70 | 2018 |
| Age‐related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration O Alvarez‐Garcia, T Matsuzaki, M Olmer, K Masuda, MK Lotz Journal of Orthopaedic Research 35 (12), 2682-2691, 2017 | 70 | 2017 |
| Rapamycin retards growth and causes marked alterations in the growth plate of young rats O Alvarez-Garcia, E Carbajo-Pérez, E Garcia, H Gil, I Molinos, ... Pediatric nephrology 22, 954-961, 2007 | 70 | 2007 |
| Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy O Alvarez-Garcia, M Olmer, R Akagi, Y Akasaki, KM Fisch, T Shen, AI Su, ... Osteoarthritis and cartilage 24 (9), 1639-1647, 2016 | 59 | 2016 |
| Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture I Vega‐Naredo, B Poeggeler, V Sierra‐Sánchez, B Caballero, ... Journal of pineal research 39 (3), 266-275, 2005 | 55 | 2005 |
| Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate Ó Álvarez-García, E García-López, V Loredo, H Gil-Pena, ... Kidney international 78 (6), 561-568, 2010 | 53 | 2010 |
| Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis Y Akasaki, N Reixach, T Matsuzaki, O Alvarez‐Garcia, M Olmer, ... Arthritis & Rheumatology 67 (8), 2097-2107, 2015 | 50 | 2015 |
| Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism T Shen, O Alvarez-Garcia, Y Li, M Olmer, MK Lotz Osteoarthritis and Cartilage 25 (2), 287-296, 2017 | 45 | 2017 |
| Activity of cathepsins during beef aging related to mutations in the myostatin gene B Caballero, V Sierra, M Olivan, I Vega‐Naredo, C Tomás‐Zapico, ... Journal of the Science of Food and Agriculture 87 (2), 192-199, 2007 | 44 | 2007 |
Andrew I. SuProfessor, The Scripps Research InstituteCorreu electrònic verificat a scripps.edu