| Phosphorylation of the translation initiation factor eIF2α increases BACE1 levels and promotes amyloidogenesis T O'Connor, KR Sadleir, E Maus, RA Velliquette, J Zhao, SL Cole, ... Neuron 60 (6), 988-1009, 2008 | 516 | 2008 |
| The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong, M Barros, T Li, P Nie, ... Nature 586 (7831), 735-740, 2020 | 309 | 2020 |
| The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques PC Kandalepas, KR Sadleir, WA Eimer, J Zhao, DA Nicholson, R Vassar Acta neuropathologica 126, 329-352, 2013 | 279 | 2013 |
| Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease KR Sadleir, PC Kandalepas, V Buggia-Prévot, DA Nicholson, ... Acta neuropathologica 132, 235-256, 2016 | 268 | 2016 |
| Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains DB Davis, KR Doherty, AJ Delmonte, EM McNally Journal of Biological Chemistry 277 (25), 22883-22888, 2002 | 246 | 2002 |
| Normal myoblast fusion requires myoferlin KR Doherty, A Cave, DB Davis, AJ Delmonte, A Posey, JU Earley, ... Oxford University Press for The Company of Biologists Limited 132 (24), 5565 …, 2005 | 245 | 2005 |
| A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease A Rocchi, S Yamamoto, T Ting, Y Fan, K Sadleir, Y Wang, W Zhang, ... PLoS genetics 13 (8), e1006962, 2017 | 159 | 2017 |
| Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level KR Sadleir, WA Eimer, SL Cole, R Vassar Molecular neurodegeneration 10, 1-16, 2015 | 130 | 2015 |
| The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion KR Doherty, AR Demonbreun, GQ Wallace, A Cave, AD Posey, K Heretis, ... Journal of Biological Chemistry 283 (29), 20252-20260, 2008 | 130 | 2008 |
| Repairing the tears: dysferlin in muscle membrane repair KR Doherty, EM McNally Trends in Molecular Medicine 9 (8), 327-330, 2003 | 111 | 2003 |
| Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer … KR Sadleir, R Vassar Journal of Biological Chemistry 287 (10), 7224-7235, 2012 | 73 | 2012 |
| ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease KR Sadleir, J Popovic, R Vassar Journal of Biological Chemistry 293 (48), 18434-18443, 2018 | 51 | 2018 |
| Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a … KR Sadleir, WA Eimer, RJ Kaufman, P Osten, R Vassar PLoS One 9 (7), e101643, 2014 | 41 | 2014 |
| Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice SE Perez, M Nadeem, KR Sadleir, J Matras, CM Kelley, SE Counts, ... International journal of physiology, pathophysiology and pharmacology 4 (3), 115, 2012 | 36 | 2012 |
| Genetic modifiers of muscular dystrophy: implications for therapy A Heydemann, KR Doherty, EM McNally Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1772 (2), 216-228, 2007 | 33 | 2007 |
| Random amplified polymorphic DNA markers reveal genetic variation in the symbiotic fungus of leaf-cutting ants KR Doherty, EW Zweifel, NC Elde, MJ McKone, SG Zweifel Mycologia 95 (1), 19-23, 2003 | 31 | 2003 |
| The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms S Chandra, A Di Meco, HB Dodiya, J Popovic, LK Cuddy, IQ Weigle, ... Molecular neurodegeneration 18 (1), 45, 2023 | 24 | 2023 |
| Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice AO Sasmita, C Depp, T Nazarenko, T Sun, SB Siems, EC Ong, YB Nkeh, ... Nature neuroscience 27 (9), 1668-1674, 2024 | 18 | 2024 |
| Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis K R Sadleir, D A Bennett, J A Schneider, R Vassar Current Alzheimer Research 10 (8), 785-789, 2013 | 15 | 2013 |
| A conserved annexin A6–mediated membrane repair mechanism in muscle, heart, and nerve AR Demonbreun, E Bogdanovic, LA Vaught, NL Reiser, KS Fallon, ... JCI insight 7 (14), 2022 | 14 | 2022 |
