| Topoisomerase I poisoning results in PARP-mediated replication fork reversal A Ray Chaudhuri, Y Hashimoto, R Herrador, KJ Neelsen, D Fachinetti, ... Nature structural & molecular biology 19 (4), 417-423, 2012 | 555 | 2012 |
| Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells AJ Holland, D Fachinetti, JS Han, DW Cleveland Proceedings of the National Academy of Sciences 109 (49), E3350-E3357, 2012 | 360 | 2012 |
| Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells C Cotta-Ramusino, D Fachinetti, C Lucca, Y Doksani, M Lopes, J Sogo, ... Molecular cell 17 (1), 153-159, 2005 | 321 | 2005 |
| A two-step mechanism for epigenetic specification of centromere identity and function D Fachinetti, H Diego Folco, Y Nechemia-Arbely, LP Valente, K Nguyen, ... Nature cell biology 15 (9), 1056-1066, 2013 | 293 | 2013 |
| The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA V Barra, D Fachinetti Nature communications 9 (1), 4340, 2018 | 292 | 2018 |
| Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining P Ly, LS Teitz, DH Kim, O Shoshani, H Skaletsky, D Fachinetti, DC Page, ... Nature cell biology 19 (1), 68-75, 2017 | 264 | 2017 |
| DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function D Fachinetti, JS Han, MA McMahon, P Ly, A Abdullah, AJ Wong, ... Developmental cell 33 (3), 314-327, 2015 | 264 | 2015 |
| The N-terminal domain of cGAS determines preferential association with centromeric DNA and innate immune activation in the nucleus M Gentili, X Lahaye, F Nadalin, GPF Nader, EP Lombardi, S Herve, ... Cell reports 26 (9), 2377-2393. e13, 2019 | 248 | 2019 |
| Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements D Fachinetti, R Bermejo, A Cocito, S Minardi, Y Katou, Y Kanoh, ... Molecular cell 39 (4), 595-605, 2010 | 196 | 2010 |
| The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle AJ Holland, D Fachinetti, Q Zhu, M Bauer, IM Verma, EA Nigg, ... Genes & development 26 (24), 2684-2689, 2012 | 178 | 2012 |
| Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy MR Ippolito, V Martis, S Martin, AE Tijhuis, C Hong, R Wardenaar, ... Developmental cell 56 (17), 2440-2454. e6, 2021 | 153 | 2021 |
| Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription R Bermejo, T Capra, V Gonzalez-Huici, D Fachinetti, A Cocito, G Natoli, ... Cell 138 (5), 870-884, 2009 | 138 | 2009 |
| Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20 JS Han, AJ Holland, D Fachinetti, A Kulukian, B Cetin, DW Cleveland Molecular cell 51 (1), 92-104, 2013 | 125 | 2013 |
| Human chromosome‐specific aneuploidy is influenced by DNA‐dependent centromeric features M Dumont, R Gamba, P Gestraud, S Klaasen, JT Worrall, SG De Vries, ... The EMBO journal 39 (2), e102924, 2020 | 115 | 2020 |
| CENP-A is dispensable for mitotic centromere function after initial centromere/kinetochore assembly S Hoffmann, M Dumont, V Barra, P Ly, Y Nechemia-Arbely, MA McMahon, ... Cell reports 17 (9), 2394-2404, 2016 | 112 | 2016 |
| Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition LY Guo, PK Allu, L Zandarashvili, KL McKinley, N Sekulic, ... Nature communications 8 (1), 15775, 2017 | 88 | 2017 |
| DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres Y Nechemia-Arbely, KH Miga, O Shoshani, A Aslanian, MA McMahon, ... Nature cell biology 21 (6), 743-754, 2019 | 84 | 2019 |
| Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics VIP Keizer, S Grosse-Holz, M Woringer, L Zambon, K Aizel, M Bongaerts, ... Science 377 (6605), 489-495, 2022 | 81 | 2022 |
| α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere KM Sathyan, D Fachinetti, DR Foltz Nature Communications 8 (1), 14678, 2017 | 76 | 2017 |
| CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy S Giunta, S Hervé, RR White, T Wilhelm, M Dumont, A Scelfo, R Gamba, ... Proceedings of the National Academy of Sciences 118 (10), e2015634118, 2021 | 74 | 2021 |