Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity JE LaVigne, R Hecksel, A Keresztes, JM Streicher Scientific reports 11 (1), 8232, 2021 | 110 | 2021 |
Analgesic potential of terpenes derived from Cannabis sativa E Liktor-Busa, A Keresztes, J LaVigne, JM Streicher, TM Largent-Milnes Pharmacological reviews 73 (4), 1269-1297, 2021 | 77 | 2021 |
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist S Tumati, TM Largent-Milnes, A Keresztes, J Ren, WR Roeske, ... Journal of neuroimmunology 244 (1-2), 23-31, 2012 | 56 | 2012 |
New endomorphin analogues containing alicyclic β-amino acids: Influence on bioactive conformation and pharmacological profile A Keresztes, M Szucs, A Borics, KE Kövér, E Forro, F Fülöp, ... Journal of Medicinal Chemistry 51 (14), 4270-4279, 2008 | 55 | 2008 |
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 … S Ballet, D Feytens, K Buysse, NN Chung, C Lemieux, S Tumati, ... Journal of medicinal chemistry 54 (7), 2467-2476, 2011 | 54 | 2011 |
Synthesis and evaluation of a novel bivalent selective antagonist for the mu-delta opioid receptor heterodimer that reduces morphine withdrawal in mice KM Olson, A Keresztes, JK Tashiro, LV Daconta, VJ Hruby, JM Streicher Journal of medicinal chemistry 61 (14), 6075-6086, 2018 | 49 | 2018 |
Recent advances in endomorphin engineering A Keresztes, A Borics, G Tóth ChemMedChem 5 (8), 1176-1196, 2010 | 49 | 2010 |
Novel molecular strategies and targets for opioid drug discovery for the treatment of chronic pain KM Olson, W Lei, A Keresztes, J LaVigne, JM Streicher The Yale journal of biology and medicine 90 (1), 97, 2017 | 47 | 2017 |
Tachykinin NK1 receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation S Tumati, TM Largent-Milnes, AI Keresztes, T Yamamoto, TW Vanderah, ... European journal of pharmacology 684 (1-3), 64-70, 2012 | 42 | 2012 |
Design, synthesis, pharmacological evaluation, and structure− activity study of novel endomorphin analogues with multiple structural modifications JR Mallareddy, A Borics, A Keresztes, KE Kövér, D Tourwé, G Tóth Journal of medicinal chemistry 54 (5), 1462-1472, 2011 | 41 | 2011 |
Analgesic properties of opioid/NK1 multitarget ligands with distinct in vitro profiles in naive and chronic constriction injury mice J Starnowska, R Costante, K Guillemyn, K Popiolek-Barczyk, NN Chung, ... ACS chemical neuroscience 8 (10), 2315-2324, 2017 | 38 | 2017 |
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors S Dvorácskó, A Keresztes, A Mollica, A Stefanucci, G Macedonio, ... European journal of medicinal chemistry 178, 571-588, 2019 | 36 | 2019 |
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist–neurokinin-1 antagonist peptidomimetics K Guillemyn, P Kleczkowska, A Lesniak, J Dyniewicz, O Van der Poorten, ... European journal of medicinal chemistry 92, 64-77, 2015 | 35 | 2015 |
Structural basis of small molecule targetability of monomeric tau protein R Kiss, G Csizmadia, K Solti, A Keresztes, M Zhu, M Pickhardt, ... ACS Chemical Neuroscience 9 (12), 2997-3006, 2018 | 31 | 2018 |
Synthesis and pharmacology of a novel μ–δ opioid receptor heteromer-selective agonist based on the carfentanyl template A Faouzi, R Uprety, I Gomes, N Massaly, AI Keresztes, V Le Rouzic, ... Journal of medicinal chemistry 63 (22), 13618-13637, 2020 | 30 | 2020 |
New endomorphin analogs with mu-agonist and delta-antagonist properties G Tóth, A Keresztes, C Tömböly, A Péter, F Fülöp, D Tourwe, ... Pure and applied chemistry 76 (5), 951-957, 2004 | 29 | 2004 |
Influence of ring substitution on the conformation and β-turn mimicry of 4-amino-1, 2, 4, 5-tetrahydro-2-benzazepin-3-one peptide mimetics R De Wachter, L Brans, S Ballet, I Van den Eynde, D Feytens, A Keresztes, ... Tetrahedron 65 (11), 2266-2278, 2009 | 25 | 2009 |
Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling A Keresztes, K Olson, P Nguyen, MA Lopez-Pier, R Hecksel, NK Barker, ... Pain 163 (1), 146-158, 2022 | 23 | 2022 |
Dual alleviation of acute and neuropathic pain by fused opioid agonist-neurokinin 1 antagonist peptidomimetics C Betti, J Starnowska, J Mika, J Dyniewicz, L Frankiewicz, A Novoa, ... ACS Medicinal Chemistry Letters 6 (12), 1209-1214, 2015 | 23 | 2015 |
Investigation of receptor binding and functional characteristics of hemopressin (1–7) S Dvorácskó, C Tömböly, R Berkecz, A Keresztes Neuropeptides 58, 15-22, 2016 | 21 | 2016 |