| α-Synuclein strains cause distinct synucleinopathies after local and systemic administration W Peelaerts, L Bousset, A Van der Perren, A Moskalyuk, R Pulizzi, ... Nature 522 (7556), 340-344, 2015 | 1252 | 2015 |
| Linking neuroinflammation and neurodegeneration in Parkinson’s disease G Gelders, V Baekelandt, A Van der Perren Journal of immunology research 2018 (1), 4784268, 2018 | 459 | 2018 |
| Targeting neuroinflammation to treat Alzheimer’s disease A Ardura-Fabregat, E Boddeke, A Boza-Serrano, S Brioschi, ... CNS drugs 31, 1057-1082, 2017 | 260 | 2017 |
| rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration M Oliveras-Salvá, A Van der Perren, N Casadei, S Stroobants, S Nuber, ... Molecular neurodegeneration 8, 1-14, 2013 | 219 | 2013 |
| The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies A Van der Perren, G Gelders, A Fenyi, L Bousset, F Brito, W Peelaerts, ... Acta neuropathologica 139, 977-1000, 2020 | 218 | 2020 |
| Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease L Vercammen, A Van der Perren, E Vaudano, R Gijsbers, Z Debyser, ... Molecular Therapy 14 (5), 716-723, 2006 | 151 | 2006 |
| Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors A Van der Perren, J Toelen, C Casteels, F Macchi, AS Van Rompuy, ... Neurobiology of aging 36 (3), 1543-1558, 2015 | 126 | 2015 |
| Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9 A Van der Perren, J Toelen, M Carlon, C Van den Haute, F Coun, ... Gene therapy 18 (5), 517-527, 2011 | 116 | 2011 |
| Endonuclease G mediates α‐synuclein cytotoxicity during Parkinson's disease S Büttner, L Habernig, F Broeskamp, D Ruli, FN Vögtle, M Vlachos, ... The EMBO journal 32 (23), 3041-3054, 2013 | 100 | 2013 |
| FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease A Van der Perren, F Macchi, J Toelen, MS Carlon, M Maris, H de Loor, ... Neurobiology of aging 36 (3), 1559-1568, 2015 | 88 | 2015 |
| Viral vector-based models of Parkinson’s disease A Van der Perren, C Van den Haute, V Baekelandt Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease, 271-301, 2015 | 77 | 2015 |
| Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation B Janssen, DJ Vugts, SM Wilkinson, D Ory, S Chalon, JJM Hoozemans, ... Scientific reports 8 (1), 6580, 2018 | 67 | 2018 |
| Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic α-synuclein administration JM Peralta Ramos, P Iribarren, L Bousset, R Melki, V Baekelandt, ... Frontiers in immunology 10, 80, 2019 | 65 | 2019 |
| Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice M Oliveras-Salvá, F Macchi, V Coessens, A Deleersnijder, M Gérard, ... Neurobiology of aging 35 (11), 2625-2636, 2014 | 65 | 2014 |
| A PET brain reporter gene system based on type 2 cannabinoid receptors C Vandeputte, N Evens, J Toelen, CM Deroose, B Bosier, A Ibrahimi, ... Journal of Nuclear Medicine 52 (7), 1102-1109, 2011 | 58 | 2011 |
| Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein E Bentea, A Van der Perren, J Van Liefferinge, A El Arfani, G Albertini, ... Frontiers in behavioral neuroscience 9, 68, 2015 | 56 | 2015 |
| Increased P2X7 receptor binding is associated with neuroinflammation in acute but not chronic rodent models for Parkinson’s disease M Crabbé, A Van der Perren, I Bollaerts, S Kounelis, V Baekelandt, ... Frontiers in Neuroscience 13, 799, 2019 | 48 | 2019 |
| Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration ASV Rompuy, E Lobbestael, AV Perren, CV Haute, V Baekelandt Journal of Neuropathology & Experimental Neurology 73 (2), 159-174, 2014 | 41 | 2014 |
| Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2 M Carlon, J Toelen, A Van der Perren, LH Vandenberghe, V Reumers, ... Molecular Therapy 18 (12), 2130-2138, 2010 | 40 | 2010 |
| Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia M Crabbé, A Van der Perren, A Weerasekera, U Himmelreich, ... Neurobiology of Aging 61, 82-92, 2018 | 36 | 2018 |