| Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ... Cell 167 (2), 457-470. e13, 2016 | 1957 | 2016 |
| Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1532 | 2018 |
| Krebs cycle reborn in macrophage immunometabolism DG Ryan, LAJ O'Neill Annual review of immunology 38, 289-313, 2020 | 367 | 2020 |
| Coupling Krebs cycle metabolites to signalling in immunity and cancer DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA O’Neill, ... Nature metabolism 1 (1), 16-33, 2019 | 361 | 2019 |
| Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 JO Early, D Menon, CA Wyse, MP Cervantes-Silva, Z Zaslona, RG Carroll, ... Proceedings of the National Academy of Sciences 115 (36), E8460-E8468, 2018 | 329 | 2018 |
| Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming D Olagnier, AM Brandtoft, C Gunderstofte, NL Villadsen, C Krapp, ... Nature communications 9 (1), 3506, 2018 | 259 | 2018 |
| A defective pentose phosphate pathway reduces inflammatory macrophage responses during hypercholesterolemia J Baardman, SGS Verberk, KHM Prange, M van Weeghel, ... Cell reports 25 (8), 2044-2052. e5, 2018 | 182 | 2018 |
| Krebs cycle rewired for macrophage and dendritic cell effector functions DG Ryan, LAJ O'Neill FEBS letters 591 (19), 2992-3006, 2017 | 143 | 2017 |
| Macrophage fumarate hydratase restrains mtRNA-mediated interferon production A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, ... Nature 615 (7952), 490-498, 2023 | 121 | 2023 |
| Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism DG Ryan, M Yang, HA Prag, GR Blanco, E Nikitopoulou, ... Elife 10, e72593, 2021 | 89 | 2021 |
| Caspase-11 promotes allergic airway inflammation Z Zasłona, E Flis, MM Wilk, RG Carroll, EM Palsson-McDermott, ... Nature Communications 11 (1), 1055, 2020 | 72 | 2020 |
| Caspase-11 promotes allergic airway inflammation E Creagh, E Lavelle, L O'Neill, K Mills, Z Zasłona, E Flis, MM Wilk, ... | 72* | 2020 |
| Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response DG Ryan, EV Knatko, AM Casey, JL Hukelmann, SD Naidu, AJ Brenes, ... IScience 25 (2), 103827, 2022 | 68 | 2022 |
| High-dimensional single-cell analysis of human natural killer cell heterogeneity L Rebuffet, JE Melsen, B Escalière, D Basurto-Lozada, A Bhandoola, ... Nature immunology, 1-15, 2024 | 53 | 2024 |
| TCA cycle signalling and the evolution of eukaryotes DG Ryan, C Frezza, LAJ O’Neill Current opinion in biotechnology 68, 72-88, 2021 | 52 | 2021 |
| Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses MLE Lundahl, M Mitermite, DG Ryan, S Case, NC Williams, M Yang, ... Elife 11, e74690, 2022 | 47 | 2022 |
| Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling MM Hughes, P Lavrencic, RC Coll, T Ve, DG Ryan, NC Williams, ... Proceedings of the National Academy of Sciences 114 (32), E6480-E6489, 2017 | 41 | 2017 |
| Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages NC Williams, DG Ryan, ASH Costa, EL Mills, MP Jedrychowski, ... Journal of Biological Chemistry 298 (2), 2022 | 40 | 2022 |
| Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ... Cell 167 (2), 457, 2016 | 37 | 2016 |
| Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression M Sciacovelli, A Dugourd, LV Jimenez, M Yang, E Nikitopoulou, ... Nature communications 13 (1), 7830, 2022 | 20 | 2022 |
