| CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy A Siddiqui-Jain, D Drygin, N Streiner, P Chua, F Pierre, SE O'Brien, ... Cancer research 70 (24), 10288-10298, 2010 | 568 | 2010 |
| Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for … F Pierre, PC Chua, SE O’Brien, A Siddiqui-Jain, P Bourbon, M Haddach, ... Journal of medicinal chemistry 54 (2), 635-654, 2011 | 351 | 2011 |
| Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer R Battistutta, G Cozza, F Pierre, E Papinutto, G Lolli, S Sarno, SE O’Brien, ... Biochemistry 50 (39), 8478-8488, 2011 | 187 | 2011 |
| Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer F Pierre, PC Chua, SE O’Brien, A Siddiqui-Jain, P Bourbon, M Haddach, ... Molecular and cellular biochemistry 356 (1), 37-43, 2011 | 175 | 2011 |
| Discovery of CX-5461, the first direct and selective inhibitor of RNA polymerase I, for cancer therapeutics M Haddach, MK Schwaebe, J Michaux, J Nagasawa, SE O'Brien, ... ACS medicinal chemistry letters 3 (7), 602-606, 2012 | 163 | 2012 |
| Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators PC Chua, JP Whitten US Patent 7,956,064, 2011 | 160 | 2011 |
| Discovery of CX-6258. A potent, selective, and orally efficacious pan-Pim kinases inhibitor M Haddach, J Michaux, MK Schwaebe, F Pierre, SE O’Brien, C Borsan, ... ACS medicinal chemistry letters 3 (2), 135-139, 2012 | 96 | 2012 |
| Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy: miniperspective D Drygin, M Haddach, F Pierre, DM Ryckman Journal of medicinal chemistry 55 (19), 8199-8208, 2012 | 84 | 2012 |
| Systems-based design of bi-ligand inhibitors of oxidoreductases: Filling the chemical proteomic toolbox DS Sem, B Bertolaet, B Baker, E Chang, AD Costache, S Coutts, Q Dong, ... Chemistry & biology 11 (2), 185-194, 2004 | 62 | 2004 |
| Modulators of cystic fibrosis transmembrane conductance regulator MT Miller, C Anderson, V Arumugam, BR Bear, HM Binch, JJ Clemens, ... US Patent 9,782,408, 2017 | 60 | 2017 |
| 7-(4H-1, 2, 4-Triazol-3-yl) benzo [c][2, 6] naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity F Pierre, E Stefan, AS Nédellec, MC Chevrel, CF Regan, A Siddiqui-Jain, ... Bioorganic & medicinal chemistry letters 21 (22), 6687-6692, 2011 | 60 | 2011 |
| Novel tricyclic protein kinase modulators M Haddach, F Pierre US Patent App. 12/883,688, 2011 | 54 | 2011 |
| Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells F Pierre, CF Regan, MC Chevrel, A Siddiqui-Jain, D Macalino, N Streiner, ... Bioorganic & medicinal chemistry letters 22 (9), 3327-3331, 2012 | 46 | 2012 |
| Quinobenzoxazine analogs and methods of using thereof JP Whitten, F Pierre, M Schwaebe US Patent App. 12/165,476, 2009 | 41* | 2009 |
| Protein kinase modulators PC Chua, M Haddach, JY Nagasawa, F Pierre, JP Whitten US Patent 8,168,651, 2012 | 39 | 2012 |
| Novel potent pyrimido [4, 5-c] quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties F Pierre, SE O’Brien, M Haddach, P Bourbon, MK Schwaebe, E Stefan, ... Bioorganic & medicinal chemistry letters 21 (6), 1687-1691, 2011 | 38 | 2011 |
| Bez názvu WO Patent 2009108912:A1, 0 | 36* | |
| P-38 inhibitors Q Dong, F Pierre, J Wang US Patent 7,652,044, 2010 | 35 | 2010 |
| Modulator of the cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator AR Abela, T Alcacio, C Anderson, PT Angell, M Baek, JJ Clemens, ... US Patent 10,793,547, 2020 | 32 | 2020 |
| The constitution of micrococcin P1: the Bycroft–Gowland hypothesis confirmed B Fenet, F Pierre, E Cundliffe, MA Ciufolini Tetrahedron letters 43 (13), 2367-2370, 2002 | 26 | 2002 |
