| Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway S Lehnardt, L Massillon, P Follett, FE Jensen, R Ratan, PA Rosenberg, ... Proceedings of the National Academy of Sciences 100 (14), 8514-8519, 2003 | 1269 | 2003 |
| Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice RJ Ferrante, JK Kubilus, J Lee, H Ryu, A Beesen, B Zucker, K Smith, ... Journal of Neuroscience 23 (28), 9418-9427, 2003 | 852 | 2003 |
| Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate SF Sleiman, J Henry, R Al-Haddad, L El Hayek, E Abou Haidar, T Stringer, ... elife 5, e15092, 2016 | 832 | 2016 |
| Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke I Alim, JT Caulfield, Y Chen, V Swarup, DH Geschwind, E Ivanova, ... Cell 177 (5), 1262-1279. e25, 2019 | 804 | 2019 |
| Rapid communication: oxidative stress induces apoptosis in embryonic cortical neurons RR Ratan, TH Murphy, JM Baraban Journal of neurochemistry 62 (1), 376-379, 1994 | 703 | 1994 |
| Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? MW Bourassa, I Alim, SJ Bultman, RR Ratan Neuroscience letters 625, 56-63, 2016 | 692 | 2016 |
| Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease G Gardian, SE Browne, DK Choi, P Klivenyi, J Gregorio, JK Kubilus, ... Journal of Biological Chemistry 280 (1), 556-563, 2005 | 532 | 2005 |
| Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis M Zille, SS Karuppagounder, Y Chen, PJ Gough, J Bertin, J Finger, ... Stroke 48 (4), 1033-1043, 2017 | 479 | 2017 |
| Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox J Lee, H Ryu, RJ Ferrante, SM Morris Jr, RR Ratan Proceedings of the National Academy of Sciences 100 (8), 4843-4848, 2003 | 440 | 2003 |
| Protection from oxidative stress–induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced dna binding of hypoxia-inducible factor-1 and atf … K Zaman, H Ryu, D Hall, K O'Donovan, KI Lin, MP Miller, JC Marquis, ... Journal of Neuroscience 19 (22), 9821-9830, 1999 | 438 | 1999 |
| Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro D Cai, K Deng, W Mellado, J Lee, RR Ratan, MT Filbin Neuron 35 (4), 711-719, 2002 | 407 | 2002 |
| HDAC6 is a target for protection and regeneration following injury in the nervous system MA Rivieccio, C Brochier, DE Willis, BA Walker, MA D'Annibale, ... Proceedings of the National Academy of Sciences 106 (46), 19599-19604, 2009 | 406 | 2009 |
| Therapeutic effects of cystamine in a murine model of Huntington's disease A Dedeoglu, JK Kubilus, TM Jeitner, SA Matson, M Bogdanov, NW Kowall, ... Journal of Neuroscience 22 (20), 8942-8950, 2002 | 402 | 2002 |
| Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration S Khanna, S Roy, H Ryu, P Bahadduri, PW Swaan, RR Ratan, CK Sen Journal of Biological Chemistry 278 (44), 43508-43515, 2003 | 383 | 2003 |
| Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: a target for neuroprotection in the central nervous system A Siddiq, IA Ayoub, JC Chavez, L Aminova, S Shah, JC LaManna, ... Journal of Biological Chemistry 280 (50), 41732-41743, 2005 | 371 | 2005 |
| Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis S Camelo, AH Iglesias, D Hwang, B Due, H Ryu, K Smith, SG Gray, ... Journal of neuroimmunology 164 (1-2), 10-21, 2005 | 336 | 2005 |
| Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway H Ryu, J Lee, BA Olofsson, A Mwidau, A Deodoglu, M Escudero, ... Proceedings of the National Academy of Sciences 100 (7), 4281-4286, 2003 | 329 | 2003 |
| Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione RR Ratan, TH Murphy, JM Baraban Journal of Neuroscience 14 (7), 4385-4392, 1994 | 313 | 1994 |
| Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons H Ryu, J Lee, K Zaman, J Kubilis, RJ Ferrante, BD Ross, R Neve, ... Journal of Neuroscience 23 (9), 3597-3606, 2003 | 295 | 2003 |
| Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative … GE Gibson, A Starkov, JP Blass, RR Ratan, MF Beal Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1802 (1), 122-134, 2010 | 290 | 2010 |
