A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia MT Henrich, FF Geibl, B Lee, WH Chiu, JB Koprich, JM Brotchie, ... Acta neuropathologica communications 6, 1-19, 2018 | 73 | 2018 |
Long-term treatment with L-DOPA or pramipexole affects adult neurogenesis and corresponding non-motor behavior in a mouse model of Parkinson's disease WH Chiu, C Depboylu, G Hermanns, L Maurer, A Windolph, WH Oertel, ... Neuropharmacology 95, 367-376, 2015 | 70 | 2015 |
Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells M Höllerhage, C Moebius, J Melms, WH Chiu, JN Goebel, T Chakroun, ... Scientific reports 7 (1), 11469, 2017 | 68 | 2017 |
Neurogenesis in substantia nigra of parkinsonian brains? O Arias-Carrión, E Yamada, N Freundlieb, M Djufri, L Maurer, ... Birth, life and death of dopaminergic neurons in the substantia nigra, 279-285, 2009 | 48 | 2009 |
Mutant α-synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in Parkinson's disease E Lasser-Katz, A Simchovitz, WH Chiu, WH Oertel, R Sharon, H Soreq, ... Journal of Neuroscience 37 (1), 47-57, 2017 | 40 | 2017 |
Selective remodeling of glutamatergic transmission to striatal cholinergic interneurons after dopamine depletion JJ Aceves Buendia, L Tiroshi, WH Chiu, JA Goldberg European Journal of Neuroscience 49 (6), 824-833, 2019 | 31 | 2019 |
Selegiline normalizes, while l-DOPA sustains the increased number of dopamine neurons in the olfactory bulb in a 6-OHDA mouse model of Parkinson's disease WH Chiu, T Carlsson, C Depboylu, GU Höglinger, WH Oertel, V Ries Neuropharmacology 79, 212-221, 2014 | 28 | 2014 |
Activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics R Rehani, Y Atamna, L Tiroshi, WH Chiu, JJA Buendía, GJ Martins, ... Eneuro 6 (1), 2019 | 26 | 2019 |
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease LA Matschke, MA Komadowski, A Stöhr, B Lee, MT Henrich, M Griesbach, ... Scientific Reports 12 (1), 3180, 2022 | 18 | 2022 |
α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms WH Chiu, L Kovacheva, RE Musgrove, H Arien-Zakay, JB Koprich, ... Science advances 7 (11), eabd3994, 2021 | 17 | 2021 |
α-Synuclein 2.0—moving towards cell type specific pathophysiology P Thakur, WH Chiu, J Roeper, JA Goldberg Neuroscience 412, 248-256, 2019 | 16 | 2019 |
Disentangling dyskinesia from parkinsonism in motor structures of patients with schizophrenia K Sakreida, WH Chiu, J Dukart, SB Eickhoff, T Frodl, C Gaser, ... Brain communications 4 (4), fcac190, 2022 | 12 | 2022 |
l-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons M Klietz, U Keber, T Carlsson, WH Chiu, GU Höglinger, E Weihe, ... Neuroscience 331, 120-133, 2016 | 11 | 2016 |
Wave-like activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics R Rehani, Y Atamna, L Tiroshi, WH Chiu, JJ Aceves Buendía, GJ Martins, ... BioRxiv, 404467, 2018 | 3 | 2018 |
Ion channel dysregulation and cellular adaptations to alpha-synuclein in stressful pacemakers of the parkinsonian brainstem WH Chiu, N Wattad, JA Goldberg Pharmacology & Therapeutics, 108683, 2024 | 2 | 2024 |
Vagal motoneurons in Parkinson's disease RE Musgrove, WH Chiu, JA Goldberg Genetics, Neurology, Behavior, and Diet in Parkinson's Disease, 327-343, 2020 | 2 | 2020 |
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease L Matschke, M Komadowski, A Stöhr, B Lee, M Henrich, M Griesbach, ... Authorea Preprints, 2024 | | 2024 |
JN403, an alpha-7-nicotine-acetylcholine-receptor agonist, reduces alpha-synuclein induced inflammatory parameters of in vitro microglia but fails to attenuate the … B Lee, C Noelker, D Feuerbach, L Timmermann, WH Chiu, WH Oertel bioRxiv, 2020.04. 04.996892, 2020 | | 2020 |
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons causes non-motor parkinsonian symptoms WH Chiu, L Kovacheva, RE Musgrove, H Arien-Zakay, JB Koprich, ... bioRxiv, 856070, 2019 | | 2019 |
Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons-a preclinical … M Henrich, L Matschke, A Stoehr, WH Chiu, B Lee, F Geibl, J Koprich, ... MOVEMENT DISORDERS 32, 2017 | | 2017 |