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Dr. Wei-Hua Chiu
Dr. Wei-Hua Chiu
NYU Langone Grossaman School of Medicine
Verificeret mail på nyulangone.org - Startside
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A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia
MT Henrich, FF Geibl, B Lee, WH Chiu, JB Koprich, JM Brotchie, ...
Acta neuropathologica communications 6, 1-19, 2018
732018
Long-term treatment with L-DOPA or pramipexole affects adult neurogenesis and corresponding non-motor behavior in a mouse model of Parkinson's disease
WH Chiu, C Depboylu, G Hermanns, L Maurer, A Windolph, WH Oertel, ...
Neuropharmacology 95, 367-376, 2015
702015
Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells
M Höllerhage, C Moebius, J Melms, WH Chiu, JN Goebel, T Chakroun, ...
Scientific reports 7 (1), 11469, 2017
682017
Neurogenesis in substantia nigra of parkinsonian brains?
O Arias-Carrión, E Yamada, N Freundlieb, M Djufri, L Maurer, ...
Birth, life and death of dopaminergic neurons in the substantia nigra, 279-285, 2009
482009
Mutant α-synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in Parkinson's disease
E Lasser-Katz, A Simchovitz, WH Chiu, WH Oertel, R Sharon, H Soreq, ...
Journal of Neuroscience 37 (1), 47-57, 2017
402017
Selective remodeling of glutamatergic transmission to striatal cholinergic interneurons after dopamine depletion
JJ Aceves Buendia, L Tiroshi, WH Chiu, JA Goldberg
European Journal of Neuroscience 49 (6), 824-833, 2019
312019
Selegiline normalizes, while l-DOPA sustains the increased number of dopamine neurons in the olfactory bulb in a 6-OHDA mouse model of Parkinson's disease
WH Chiu, T Carlsson, C Depboylu, GU Höglinger, WH Oertel, V Ries
Neuropharmacology 79, 212-221, 2014
282014
Activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics
R Rehani, Y Atamna, L Tiroshi, WH Chiu, JJA Buendía, GJ Martins, ...
Eneuro 6 (1), 2019
262019
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease
LA Matschke, MA Komadowski, A Stöhr, B Lee, MT Henrich, M Griesbach, ...
Scientific Reports 12 (1), 3180, 2022
182022
α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms
WH Chiu, L Kovacheva, RE Musgrove, H Arien-Zakay, JB Koprich, ...
Science advances 7 (11), eabd3994, 2021
172021
α-Synuclein 2.0—moving towards cell type specific pathophysiology
P Thakur, WH Chiu, J Roeper, JA Goldberg
Neuroscience 412, 248-256, 2019
162019
Disentangling dyskinesia from parkinsonism in motor structures of patients with schizophrenia
K Sakreida, WH Chiu, J Dukart, SB Eickhoff, T Frodl, C Gaser, ...
Brain communications 4 (4), fcac190, 2022
122022
l-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons
M Klietz, U Keber, T Carlsson, WH Chiu, GU Höglinger, E Weihe, ...
Neuroscience 331, 120-133, 2016
112016
Wave-like activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics
R Rehani, Y Atamna, L Tiroshi, WH Chiu, JJ Aceves Buendía, GJ Martins, ...
BioRxiv, 404467, 2018
32018
Ion channel dysregulation and cellular adaptations to alpha-synuclein in stressful pacemakers of the parkinsonian brainstem
WH Chiu, N Wattad, JA Goldberg
Pharmacology & Therapeutics, 108683, 2024
22024
Vagal motoneurons in Parkinson's disease
RE Musgrove, WH Chiu, JA Goldberg
Genetics, Neurology, Behavior, and Diet in Parkinson's Disease, 327-343, 2020
22020
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease
L Matschke, M Komadowski, A Stöhr, B Lee, M Henrich, M Griesbach, ...
Authorea Preprints, 2024
2024
JN403, an alpha-7-nicotine-acetylcholine-receptor agonist, reduces alpha-synuclein induced inflammatory parameters of in vitro microglia but fails to attenuate the …
B Lee, C Noelker, D Feuerbach, L Timmermann, WH Chiu, WH Oertel
bioRxiv, 2020.04. 04.996892, 2020
2020
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons causes non-motor parkinsonian symptoms
WH Chiu, L Kovacheva, RE Musgrove, H Arien-Zakay, JB Koprich, ...
bioRxiv, 856070, 2019
2019
Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons-a preclinical …
M Henrich, L Matschke, A Stoehr, WH Chiu, B Lee, F Geibl, J Koprich, ...
MOVEMENT DISORDERS 32, 2017
2017
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Artikler 1–20