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Mark Isalan
Mark Isalan
Professor of Synthetic Biology, Imperial College London
Verificeret mail på imperial.ac.uk - Startside
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Evolvability and hierarchy in rewired bacterial gene networks
M Isalan, C Lemerle, K Michalodimitrakis, C Horn, P Beltrao, E Raineri, ...
Nature 452 (7189), 840-845, 2008
3792008
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity
S Tan, D Guschin, A Davalos, YL Lee, AW Snowden, Y Jouvenot, ...
Proceedings of the National Academy of Sciences 100 (21), 11997-12002, 2003
2752003
A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter
M Isalan, A Klug, Y Choo
Nature biotechnology 19 (7), 656-660, 2001
2752001
Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice
M Garriga-Canut, C Agustín-Pavón, F Herrmann, A Sánchez, M Dierssen, ...
Proceedings of the National Academy of Sciences 109 (45), E3136-E3145, 2012
2532012
Gene therapy advances: a meta-analysis of AAV usage in clinical settings
HKE Au, M Isalan, M Mielcarek
Frontiers in medicine 8, 809118, 2022
2392022
Synergy between adjacent zinc fingers in sequence-specific DNA recognition
M Isalan, Y Choo, A Klug
Proceedings of the National Academy of Sciences 94 (11), 5617-5621, 1997
2351997
Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers
M Isalan, A Klug, Y Choo
Biochemistry 37 (35), 12026-12033, 1998
1811998
Repression of the HIV-1 5′ LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors
L Reynolds, C Ullman, M Moore, M Isalan, MJ West, P Clapham, A Klug, ...
Proceedings of the National Academy of Sciences 100 (4), 1615-1620, 2003
1722003
A unified design space of synthetic stripe-forming networks
Y Schaerli, A Munteanu, M Gili, J Cotterell, J Sharpe, M Isalan
Nature communications 5 (1), 4905, 2014
1642014
Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors
M Papworth, M Moore, M Isalan, M Minczuk, Y Choo, A Klug
Proceedings of the National Academy of Sciences 100 (4), 1621-1626, 2003
1612003
Engineering Gene Networks to Emulate Drosophila Embryonic Pattern Formation
M Isalan, C Lemerle, L Serrano
PLoS biology 3 (3), e64, 2005
1472005
Advances in zinc finger engineering
Y Choo, M Isalan
Current Opinion in Structural Biology 10 (4), 411-416, 2000
1352000
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein
F Guidez, L Howell, M Isalan, M Cebrat, RM Alani, S Ivins, I Hormaeche, ...
Molecular and cellular biology 25 (13), 5552-5566, 2005
1182005
Nucleic acid binding proteins
Y Choo, A Klug, M Isalan
US Patent 6,746,838, 2004
1142004
Nucleic acid binding proteins
Y Choo, A Klug, M Isalan
US Patent 6,866,997, 2005
1062005
A comprehensive network atlas reveals that Turing patterns are common but not robust
NS Scholes, D Schnoerr, M Isalan, MPH Stumpf
Cell systems 9 (3), 243-257. e4, 2019
982019
Combining a toggle switch and a repressilator within the AC-DC circuit generates distinct dynamical behaviors
R Perez-Carrasco, CP Barnes, Y Schaerli, M Isalan, J Briscoe, KM Page
Cell systems 6 (4), 521-530. e3, 2018
942018
Zinc-finger nucleases: how to play two good hands
M Isalan
Nature methods 9 (1), 32-34, 2012
912012
Selection of zinc fingers that bind single-stranded telomeric DNA in the G-quadruplex conformation
M Isalan, SD Patel, S Balasubramanian, Y Choo
Biochemistry 40 (3), 830-836, 2001
782001
Engineering orthogonal dual transcription factors for multi-input synthetic promoters
AK Brödel, A Jaramillo, M Isalan
Nature communications 7 (1), 13858, 2016
732016
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Artikler 1–20